CREATION, PHYSICAL AND CHEMICAL PROPERTIES OF ALKIL-2-((5-PHENETHYL-4-R-1,2,4- TRIAZOLE-3-YL)THIO)ACET(PROPAN,BENZ)IMIDATES

IGNATOVA TATYANA; KAPLAUSHENKO ANDRIY; NAGORNA NATALIYA; AVRAMENKO ANTONINA

doi:10.22159/ajpcr.2019.v12i3.30763

Authors

IGNATOVA TATYANA Department of Physical and Colloidal Chemistry, Farmaceutical Faculty, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine.
KAPLAUSHENKO ANDRIY Department of Physical and Colloidal Chemistry, Farmaceutical Faculty, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine. http://orcid.org/0000-0003-3704-5539
NAGORNA NATALIYA Department of Physical and Colloidal Chemistry, Farmaceutical Faculty, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine.
AVRAMENKO ANTONINA Department of Physical and Colloidal Chemistry, Farmaceutical Faculty, Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i3.30763

Keywords:

1,2,4-Triazole, Synthesis, Physical and chemical properties

Abstract

Objective: The aim of this research was to synthesize and evaluate physical-chemical properties of 5-pheneyhyl-4-R-3-thio-1,2,4-triazole and to establish identity and structure of the synthesized compounds, namely alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)acet(propan,benz)imidates.

Methods: As starting materials for synthesis of alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)acet(propan,benz)imidates, the corresponding 2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio)aceto(propane,benzo)nitrile have been used. Synthesis has been set in the absolute alcohol medium (propanol or butanol alcohol) with chloroform, using the saturation with dry hydrogen chloride.

Results: In this study, we have developed nine new compounds have been received as a result of synthetic transformations, the structure of synthesized compounds has been confirmed by modern complex of physical-chemical methods of analysis (1H NMR-spectroscopy, elemental analysis), and their individuality has been conducted on gas-liquid chromatograph Agilent 1260 Infinity HPLC equipped with a mass spectrometer Agilent 6120.

Conclusion: As a result of the work, it was synthesized the new compounds of the series of alkil-2-((5-phenethyl-4-R-1,2,4-triazole-3-yl)thio) acet(propan,benz)imidates and was characterized by elemental analysis and proton nuclear magnetic resonance spectroscopic analysis.

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