DESIGN AND DEVELOPMENT OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF CIPROFLOXACIN HYDROCHLORIDE
DOI:
https://doi.org/10.22159/ajpcr.2018.v11s4.31722Keywords:
Floating tablets, Ciprofloxacin hydrochloride, Hydroxypropyl methylcellulose K4M, Buoyancy lag timeAbstract
Objective: The aim is to prepare the floating tablet of ciprofloxacin and to improve their bioavailability in the treatment against the Gram-positive and Gram-negative microorganisms. Ciprofloxacin HCL is an acidic drug used for respiratory tract infection, diarrhea, skin infection, thyroid fever, and urinary tract infection. The ciprofloxacin HCL is primarily absorbed in the stomach and it has low bioavailability. Due to its low availability, it was chosen as an appropriate drug for the scheme of the gastroretentive floating drug delivery system.
Method: Ciprofloxacin HCl is an acidic drug which was made by wet granulation process using various polymers, which include hydroxypropyl methylcellulose K4M, Eudragit, and Guar gum with a different composition. The gas generating agents such as saleratus and citric acid were used for the preparation. The prepared granules were subjected to pre-compression parameters technique and the formulated tablets were subjected to post-compression parameters, respectively.
Result: The Fourier-transform infrared analysis reveal that the drug and excipients used for the formulations were compatible with each other. All formulated granules having good flow properties and all the post-compression parameter are within the limit in which the F4 formulation shows optimum drug release of about 98.7% at 12 h and which has the buoyancy lag time of about 134 s and floating time about 12.5 h. Kinetic treatment revealed of the optimized preparation is based on Korsmeyer–Peppas model. The value n=0.861 states the process of non-Fickian diffusion.
Conclusion: Based on above observation found in the work, it was concluded that ciprofloxacin HCl can formulate as a floating drug delivery system which helps in increasing the gastric residence time, as a result, it increases the bioavailability and half-life of ciprofloxacin HCl.
Downloads
References
Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems. Trop J Pharma Res 2008;7:1055-66.
Jeganath S, Shafiq MK, Mahesh PG, Kumar SS. Formulation and evaluation of non-effervescent floating tablet of linagliptin using low-density carrier. Drug Invent Today 2018;1:322-9.
Hilton AK, Deasy PB. In vitro and in vivo evaluation of an oral sustained release floating dosage form of amoxicillin trihydrate. Int J Pham 1992;86:79-88.
Seth PR, Tossounian J. The hydrodynamic ally balanced system, a novel drug delivery system for oral use. Drug Dev Ind Pharm 1984;10:313-39.
Whitehead L, Fell JT, Collett JH. Development of a gastro-retentive dosage form. Eur J Pharm Sci 1996;4:182.
Moes AJ. Gastro retentive dosage forms. Crit Rev Drug Carrier Syst 1993;10:143-95.
Hwang SJ, Park H, Park K. Gastric retentive drug-delivery systems. Crit Rev Ther Drug Carrier Syst 1998;15:243-84.
Mukhopadhyay S, Goswami L, Madhav NV, Upadhyaya K. Formulation and evaluation of floating bioadhesive tablets of ciprofloxacin hydrochloride by direct compression technique. Int J Pharm Pharm Sci 2010;2:113-5.
Yeole PG, Khan S, Patel VF. Floating drug delivery systems: Need and development. Indian J Pharm Sci 2005;67:265.
Yang L, Eshraghi J, Fassihi R. A new intragastric delivery system for the treatment of helicobacter pylori associated gastric ulcer: In vitro evaluation. J Control Release 1999;57:215-22.
Timmermans J, Moës AJ. Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: New data for reconsidering the controversy. J Pharma Sci 1994;1:18-24.
Blanquet S, Zeijdner E, Beyssac E, Meunier JP, Denis S, Havenaar R, et al. Dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Pharm Res 2004;4:585-91.
Salunke RJ, Shahi SR, Atram SC, Neb GB, Patil S. Formulation and evaluation of hydrodynamically balanced system of ciprofloxacin HCl. Int J Pharm Res Dev 2009;7:001.
Mostafavi A, Emami J, Varshosaz J, Davies NM, Rezazadeh M. Development of a prolonged-release gastroretentive tablet formulation of ciprofloxacin hydrochloride: Pharmacokinetic characterization in healthy human volunteers. Int J Pharm 2011;2:128-36.
Srikanth MV, Sunil SA, Janakiram B, Murthy KV. Design and in vitro evaluation of effervescent gastric floating drug delivery systems
of propranolol HCl. Invest Clin 2012;53:60-70.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
