CLINICAL EVALUATION OF MANAGEMENT AND PREVALENCE OF TYPE TWO DIABETES MELLITUS COMPLICATIONS IN SOUTH INDIAN POPULATION

Geetha P

doi:10.22159/ajpcr.2018.v11s4.31733

Authors

Geetha P Department of Pharmacy Practice, Vels Institute of Science, Technology and Advanced Studies, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s4.31733

Keywords:

Glycosylated hemoglobin, Fasting blood sugar, Post-prandial blood sugar

Abstract

Objective: The present study was aimed to assess the prevalence of complications and to assess the targets achieved during the management of diabetes mellitus type 2.

Methods: The study was prospective and conducted out in a diabetes center, Chennai, ethical approval was obtained from the Institutional Ethics Committee, case records of the 300 patients diagnosed with type 2 diabetes mellitus and its complications were monitored during March 2017â€“April 2018. Major result actions are body weight, height, body mass index (BMI), blood pressure, fasting blood sugar (FBS), post-prandial blood sugar (PPBS) levels, glycosylated hemoglobin, serum lipids, and presence of complications of diabetes. Comparison of the average of various biochemical parameters was made in patients with and no diabetic complications.

Results: The average age of 300 patients was found to be 55.006Â±13.04. The average BMI was 27.10Â±12.81 kg/m2. The average duration of diabetes was 10.48Â±7.53. The average of systolic (SBP) and diastolic blood pressure was 137Â±20.88 and 79.95Â±11.81. The mean glycated hemoglobin, FBS, PPBS, low-density lipoprotein, high-density lipoprotein, and triglyceride, and total cholesterol were found to be 8.5Â±3.99, 148.85Â±55.64 mg/dl, 200.98Â±72.63 mg/dl, 88.06Â±19.46 mg/dl, 36.20Â±8.27 mg/dl, 141.22Â±60.15 mg/dl, and 144.45Â±29.03 mg/dl, respectively. Among the microvascular complications; neuropathy, nephropathy, and retinopathy were documented in 8.33%, 23.66%, and 17.33% of patients, respectively. The prevalence of peripheral artery disease was 20.66%.

Conclusion: The prevalence of diabetic complications is significantly increased with patients age, duration, SBP, low-density lipoprotein,

total cholesterol, and post-prandial blood sugar levels. Knowledge concerning the supervision of target blood pressure and lipid

parameters is need further than the glycemic manage among diabetes patients type two.

Downloads

Download data is not yet available.

References

Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes (UKPDS 35): Prospective observational study. BMJ 2000;321:405-12.

ADVANCE Collaborative Group; Patel A, MacMahon S, Chalmers J, Neal B, Billot L, et al. Intensive blood glucose control and vascular outcomes in patients with Type 2 diabetes. N Engl J Med 2008;358:2560-72.

Chawla A, Chawla R, Bhasin GK, Soota K. Profile of adolescent diabetes in North Indian population. J Clin Diabetol 2014;1:1-3.

Rao CR, Kamath VG, Shetty A, Kamath A. A cross-sectional analysis of obesity among a rural population in coastal Southern Karnataka, India. Australas Med J 2011;4:53-7.

Mohan V, Deepa R. Obesity and abdominal obesity in Asian Indians. Indian J Med Res 2006;123:593-6.

Zargar AH, Khan AK, Masoodi SR, Laway BA, Wani AI, Bashir MI, et al. Prevalence of Type 2 diabetes mellitus and impaired glucose tolerance in the Kashmir valley of the Indian subcontinent. Diabetes Res Clin Pract 2000;47:135-46.

Misra A, Khurana L. Obesity-related non-communicable diseases: South Asians vs white caucasians. Int J Obes (Lond) 2011;35:167-87.

Jones PH. Clinical significance of recent lipid trials on reducing risk in patients with Type 2 diabetes mellitus. Am J Cardiol 2007;99:133B-140B.

Arambewela MH, Somasundaram NP, Jayasekara HB, Kumbukage MP, Jayasena PM, Chandrasekara P, et al. Prevalence of chronic complications, their risk factors, and the cardiovascular risk factors among patients with Type 2 diabetes attending the diabetic clinic at a tertiary care hospital in Sri Lanka. J Diabetes Res 2018;2018:10.

DCCT Research Group. The absence of a glycemic threshold for the development of long-term complications: The perspective of the diabetes control and complications trial. Diabetes 1996;45:1289-98.

Unnikrishnan R, Anjana RM, Deepa M, Pradeepa R, Joshi SR, Bhansali A, et al. Glycemic control among individuals with self-reported diabetes in India â€“ the ICMR-INDIAB study. Diabetes Technol Ther 2014;16:596-603.

Samantha P, Venkateswaralu M, Praboth S. The role of biochemical markers in the prediction of microvascular complications in Type-2 diabetes mellitus 2011. J Clin Diagn Res 2011;6:1154-57.

Ladeia AM, Adan L, Couto-Silva AC, Hiltner A, GuimarÃ£es AC. Lipid profile correlates with glycemic control in young patients with Type 1 diabetes mellitus. Prev Cardiol 2006;9:82-8.

Huang ES, Meigs JB, Singer DE. The effect of interventions to prevent cardiovascular disease in patients with Type 2 diabetes mellitus. Am J Med 2001;111:633-42.

Hanefeld M, Fischer S, Julius U, Schulze J, Schwanebeck U, Schmechel H, et al. Risk factors for myocardial infarction and death in newly detected NIDDM: The diabetes intervention study, 11-year follow-up. Diabetologia 1996;39:1577-83.

Haghighatpanah M, Thunga G, Khare S, Mallayasamy S. Correlation of glycosylated hemoglobin levels with fasting and postprandial glucose in South Indian Type 2 diabetic patients. Int J Pharm Pharm Sci 2016;8:285-8.