ALOE VERA: AN ASSURED WEIGHT LOSS DIET – AN APPROACH TOWARD IMPROVING THE JUICE PALATABILITY AND IN SILICO ANALYSIS
Keywords:Obesity,, Aloe vera,, Weight loss,, Aloe vera juice,, In silico analysis,, Docking studies,, Inositol hexakisphosphate kinase 1
Objective: Obesity is an epidemic disease act as causative for global death. The principal aim of this study is to create an obesity treatment beverage that is palatable and readily acceptable to the public. Aloe vera juice is one such drink known to assist in reducing obesity. This juice is sold at several places in Chennai and more easily available for morning walkers along the Marina beach. Although known for its benefits in promoting a slim and fit physique, its taste is less palatable. The objective of this study is to develop a concoction that will make the A. vera juice tasty without compromising its nutritive value.
Materials and Methods: The taste is achieved by the addition of various fruit juices such as orange, lime, sweet lime, muskmelon, and pineapple with honey and stevia for sweetening. The weight loss ability of the prepared drinks is evaluated using pancreatic lipase inhibitory and the presence of phytochemicals. To the credit, the present study also determines the efficiency of A. vera compounds for its antiobesity property through in silico techniques. The significant interaction exhibited by the compounds with the antiobesity target inositol hexakisphosphate kinase 1 (IP6K1) was discussed.
Results: The recipe B containing orange juice: A. vera juice: stevia in the ratio 3:3:1 had good taste and the significant lipase activity. The phytochemicals present in the A. vera are tannins, flavonoids, alkaloids, steroids, and polyphenols, and these phytochemicals are observed having significant interaction with protein IP6K1. Aloin A and aloe emodin had significant Glide score and interactions with active site residues.
Conclusion: Natural herbal products for weight reduction may be effective in the treatment of obesity and associated disorders. The potential lipase inhibition activity of juice may be due to the presence of various phytochemicals such as flavonoids, polyphenol etc. in the Aloe vera.
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