FORMULATION AND EVALUATION OF MICROEMULSION GEL FOR TRANSDERMAL DELIVERY OF TRAMADOL

MURUGANANTHAM V; PRABAKARAN M; PASUPATHI C; PEELY LR; POOJA B

doi:10.22159/ajpcr.2019.v12i5.32479

Authors

MURUGANANTHAM V Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation, Salem, Tamil Nadu, India.
PRABAKARAN M Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation, Salem, Tamil Nadu, India.
PASUPATHI C Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation, Salem, Tamil Nadu,
PEELY LR Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation, Salem, Tamil Nadu, India.
POOJA B Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation, Salem, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i5.32479

Keywords:

Tramadol, Microemulsion gel, Transdermal drug delivery system

Abstract

Objective: The present work was carried out to design microemulsion gel system for transdermal delivery of the drug to minimize the side effects and to reduce the frequency of administration and for prolonging the duration of action.

Methods: Tramadol, an opioid analgesic drug, was mixed with various selected polymers such as sodium alginate (SA), acacia, hydroxypropyl methylcellulose (HPMC), and Eudragit in geometric mixing ratios. The drug, polymer, and other excipients were mixed thoroughly by trituration method and different formulations (F1-F8) were prepared the same quantity of all the ingredients excepting the polymers.

Results: The different formulations prepared, studied, and showed that the formulation using SA as polymeric carrier had a better effect on the evaluated parameters. The drug-SA formulation exhibited better drug-polymer compatibility, optimal viscosity (2750 cps), zeta potential (−26.1 Mv), and particle size distribution (262.8 d.nm) values. The in vitro release studies also indicated that the drug-SA formulation was of desirable release pattern, thus indicating that SA to be a better choice in formulating a transdermal delivery gel system.

Conclusion: Evaluated microemulsion gel formulation F2 of tramadol with polymeric carriers SA was much stable than other carriers used. Thus, it could be concluded that the gel formulation with SA can be taken as an ideal formulation.

Downloads

Download data is not yet available.

References

Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 2000;45:89-121.

Cevc G, Vierl U. Nanotechnology and the transdermal route: A state of the art review and critical appraisal. J Control Release 2010;141:277-99.

Marti-Mestres G, Nielloud F. Emulsions in health care applications an overview. J Disperse Sci Tech 2002;23:419-39.

Ansel HC, Allen LV, Popovich NG. Pharmaceutical Dosage Forms and Drug Delivery Systems. 7th ed. New York: Lippincott Williams and Wilkins; 1999.

Desai KG. Enhanced skin permeation of rofecoxib using topical microemulsion gel. Drug Dev Res 2004;63:33-40.

Barot BS, Parejiya PB, Patel HK, Mehta DM, Shelat PK. Microemulsion-based antifungal gel delivery to nail for the treatment of onychomycosis: Formulation, optimization, and efficacy studies. Drug Deliv Transl Res 2012;2:463-76.

Fanun M. Microemulsions as delivery systems. Curr Opin Colloid Interface Sci 2012;17:306-13.

Silva AE, Barratt G, Chéron M, Egito ES. Development of oil-in-water microemulsions for the oral delivery of amphotericin B. Int J Pharm 2013;454:641-8.

Kandadi P, Syed MA, Goparaboina S, Veerabrahma K. Albumin coupled lipid nanoemulsions of diclofenac for targeted delivery to inflammation. Nanomedicine 2012;8:1162-71.

Saleem MA, Sanaullah S, Faizan S. Formulation and evaluation of gatifloxacin topical gels. Ind Pharm 2006;2:88-92.

Aulton ME. Pharmaceutics the Science of Dosage Form Design. 2nd ed. Vol. 41. New York: Charchil Livingstone; 1988. p. 355-6.

Lieberman HA, Rieger MM, Banker GS. Schoenwald and Flanagan in Pharmaceutical Dosage Forms Vol-II Dispersed System. New York: Marcel Dekker; 1989. p. 145-152.

Baird R. British Pharmacopoeia. Vol. 2. London: HMSO; 1993. p. A184-90.

USP-NF 18 United State Pharmacopoeias. The National Formulary. Bethesda, Maryland: Mack Publishing Co; 1985. p. 1681-6.

Ahlneck C, Zografi G. The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state. Int J Pharm 1990;62:87-5.

ICH Guideline Published by Europian Medicines Agency CAMP/ ICH/2736/99 August; 2003.

Available from: http://www.ichguidelines.com.