A REVIEW ON LEVOFLOXACIN INSITU GEL
Abstract
Â
Eye drops that are conventional ophthalmic delivery systems often result in poor bioavailability and therapeutic response, because high tear fluid turns over and dynamics cause rapid precorneal `elimination of the drug. A high frequency of eye drop instillation is associated with patient non-compliance. Inclusion of excess drug in the formulation is an attempt to overcome bioavailability problem is potentially dangerous if the drug solution drained from the eye is systemically absorbed from the Nasolachrymal duct. Various ophthalmic vehicles such as inserts, ointments, Suspensions and aqueous gels have been developed in order to lengthen the residence time of instilled dose and enhance the ophthalmicbioavailability.These ocular drug delivery system show ever have not been used extensively because of some drawbacks such as blurred vision from ointments or low patient compliance from inserts.
Downloads
References
EC Mohan, K Jagan Mohan, A Venkatesham, Preparation and evaluation of in situ gels for ocular drug delivery. J pharm Res 2009, 1089- 1094.
Lekhraj verma, Mohammad Sakir, Navdeep Singh, RituMehra, Gilhotra and Sidharth Mehan. Development of Phase change solutions for ophthalmic drug delivery based on ion activated and ph induced polymer, International Journal Of Pharma Professional’s research 2010, 137-144.
Sirish Vodithala, Sadhnakhatry, Nalinishastri, Sadanandam M. Formulation and evaluation of ion activated ocular gels of ketorolac tromethamine. Int J Curr Pharm Res. 2010, 33-38.
Amal El-kamel, Heba Al-Dosari, Fahad Al- Jenoobi. Environmentally responsive ophthalmic gel formulation of carteolol Hydrochloride. Drug Del 2006, 55-59.
Jcarlfors, K Edsman, R Peterson, K Jornving , Rheological evalution of in situ gels.Eur
j pharm sci 1998,113
B. Srividya, R. M. Cardoza and. Amin P. D, Sustained ophthalmic delivery of ofloxacin from a pH-triggered in situ gelling system. J. Contr. Rel. 2001; 205–211.
RC Doijad, FV Manvi, VSN Malleswara, Prajakta Alase. Sustained ophthalmic delivery of Gatifloxacin from in Situ Gelling System.Ind J PharmSci.2006, 809-814.
H.S Divyesh, T Shailesh, Prajapathi, K Rajesh, Parikh, Patel D Lakshmanbhai. Studies on poloxamer based muco adhesive ophthalmic in situ hydrogel of MoxifloxacinHcl. Int j Pharm Res.2009, 77-86.
H Bothner, T Waaler, O Wik. Rheological characterization of tear substitutes. Drug DevInd Pharm. 1990, 755–768.
J Padma Preetha, K Karthika, NR Rekha and Khalid Elshafie. Formulation and evaluation of in situ ophthalmic gels of Diclofenac sodium. J. Chem. Pharm. Res., 2010, 528-535.
Controller of Publication. Indian Pharmacopoeia, Vol. 2, Ministry of Health and FamilyWelfare, Government of India, New Delhi, pp: A117- A147.
Farah Siddiqui, AbulKalam ,NayyarParvez SumanYadav ,Yasmin Sultana , Asgar Ali , M Aqil , A.K Mishra and K Chuttani. Gellan-based systems for sustained ophthalmic delivery of ofloxacin. Continental J. Pharmaceutical Sciences. 2008, 1 – 14.
J Draize, G Woodward, O Calvery. Methods for the study of irritation and toxicity of substance applied topically to the skin and mucous membrane. J PharmacolExpTher. 1994,377– 390.
Harish NM, Prabhu P, Charayu RN and Subrahmanyam, Formulation and evaluation of Insitu gel containing clotrimazole for oral candidiasis. Indian J Pharm Sci 2009, 421â€427.
Eaga Chandra Mohan JM, Kandukuri V, Allenki, Journal of Pharmacy Research 2009, 1089â€1094.
Wen Di Ma, Hui Xu, Chao Wang, Shuâ€Fang Nie, Weiâ€San Pan, Int J Pharm 2008;247–256.
Himanshu Gupta, Sanyog Jain, Rashi Mathur, Pushpa Mishra, Anil K Mishra, T Velpandian Drug Deliv 2007 Nov; 14,507†15.
Cao Y, Zhang C, Shen W, Cheng Z, Yu LL, Ping Q. J Control Release. 2007; 12,186â€94.
Elâ€Kamel A, Alâ€Dosari H, Alâ€Jenoobi F. Environmentally responsive ophthalmic gel formulation of carteolol HCl. Drug Delivery. 2006;55â€59.
Dong In Ha, Sang Bong Lee, Moo Sang Chong, and Young Moo Lee, Macromolecular Research 2006; Vol. 14, 87â€93.
Sreenivas SA, Hiremath SP and Godbole AM, Ofloxacin ocular inserts: Design, Formulation and Evaluation. Iranian Journal of Pharmacology & Therapeutics 2006; Vol. 5, 159â€162.
Liu Z, Li J, Nie S, Liu H, Ding P, Pan W, Study of an alginate/HPMCâ€based insitu
gelling ophthalmic delivery system for gatifloxacin. Int J Pharm 2006; 31,12â€7.
Liu Z, Pan W, Nie S, Zhang L, Yang X, Li J, Preparation and evaluation of sustained ophthalmic gel of enoxacin Drug Dev Ind Pharm. 2005; 31(10):969â€75. Aminabhavi TM, Agnihotri SA, Naidu BVK. Rheological properties and drug release characterization of pH responsive hydrogels. J Appl Polym Sci 2004;2057â€2064.
Balasubramaniam J, Pandit JK, Ionâ€activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride. Drug Deliv 2003;185â€91.
Ishibashi Tejraj, Yokoi N, Born JA, Tiffany MJ, Komuro A, Kinoshita S. Retention of reversibly thermoâ€gelling timolol on the human ocular surface studied by video meniscometry,
Current Eye Research 2003; 117â€22.
Vadnere M, Amidon G, Lindenbaum S, Haslam JL. Int J Pharm1984;207.
Zhidong L, Jiawei L, Shufang N, Hui L, Pingtian Ding, Weisan P Study of an alginate/HPMC based Insitu gelling ophthalmic delivery system for gatifloxacin. Int J Pharm 2006;12–17.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.