TERMINALIA ARJUNA TRANSDERMAL MATRIX FORMULATION CONTAINING DIFFERENT POLYMER COMPONENTS

TERMINALIA ARJUNA TRANSDERMAL MATRIX FORMULATION

Authors

  • DINANATH GAIKWAD Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.
  • NAMDEO JADHAV Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i6.32643

Keywords:

Chitosan,, Eudragit RL 100,, Terminalia arjuna,, Transdermal

Abstract

Objective: The objective of this research work was to prepare a transdermal matrix formulation containing different polymer components for topical delivery.

Methods: Terminalia arjuna bark extract loaded transdermal patches were prepared using solvent casting technique with different amount of chitosan and Eudragit RL 100 batches were prepared according to 32 factorial designs.

Results: The transdermal patches prepared were evaluated for different physicochemical properties, determination of drug content, in vitro diffusion study, ex vivo study, skin irritation study, and stability study. Infrared studies indicate the absence of chemical interaction or any changes in the chemical composition of extract during the preparation of transdermal patch. In vitro diffusion study and ex vivo diffusion study of optimized batch S3 showed drug releases to 74.56–69.12%, respectively, up to 12 h. Skin irritation study indicates that the extract and excipients used in the patch do not show any irritating effect on the skin. All the prepared transdermal matrix formulations were found to be stable on storage.

Conclusion: It can be concluded that prepared matrix formulation containing different polymer components can be used for transdermal delivery for the treatment of chronic ailments such as cardiovascular disorder.

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References

Shankar R, Tiwari V, Mishra CP, Singh CK, Sharma D, Jaiwal S. Formulation and evaluation of ketoconazole nanoemulsion gel for topical delivery. Am J Pharm Tech Res 2015;5:445-62.

Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M, Ali A. Transdermal drug delivery: The inherent challenges and technological advancements. Asian J Pharm Sci 2010;5:276-89.

Ahad A, Al-Jenoobi FI, Al-Mohizea AM, Akhtar N, Raish M, Aqil M, et al. Systemic delivery of β-blockers via transdermal route for hypertension. Saudi Pharm J 2015;23:587-602.

Shingade GM, Quazi A, Sabale PM, Grampurohit ND, Gadhave MV, Jadhav SL, et al. Review on: Recent trend on transdermal drug delivery system. J Drug Deliv Ther 2012;2:66-76.

Ram A, Lauria P, Gupta R, Kumar P, Sharma VN. Hypocholesterolaemic effects of Terminalia arjuna tree bark. J Ethnopharmacol 1997;55:165-69.

Bachaya HA, Iqbal Z, Khan MN, Jabbar A, Gilani AH, Din IU. In vitro and in vivo anthelmintic activity of Terminalia arjuna bark. Int J Agric Biol 2009;11:273-8.

Phanikumar G, Navya K, Ramya EM, Venkataramana M, Anand T, Anilakumar KR. DNA damage protecting and free radical scavenging properties of Terminalia arjuna bark in PC-12 cells and plasmid DNA. Free Radic Antioxid 2013;3:35-9.

Dwivedi S. Terminalia arjuna wight and amp; Arn. a useful drug for cardiovascular disorders. J Ethnopharmacol 2007;114:114-29.

Gaikwad D, Jadhav N. A review on biogenic properties of stem bark of Terminalia arjuna: An update. Asian J Pharm Clin Res 2018;11:35-9.

Prabhakara P, Koland M, Vijaynarayana K, Harish NM, Shankar G, Ahmed MG. Preparation and evaluation of transdermal patches of papaverine hydrochloride. Int J Res Pharm Sci 2010;1:259-66.

Patel RR, Patel ZK, Patel KR, Patel MR. Formulation and evaluation of microemulsion based gel of ketoconazole. Int J Univers Pharm Bio Sci 2014;3:93-111.

Derie DV, Burade KB, Kotwal RS, Galkwad VB. Formulation and evaluation of microemulsion based gel for topical delivery of ketoconazole. Indian Drugs 2008;45:138-40.

Jufri M, Natalia M. Physical stability and antibacterial activity of black cumin oil (Nigella sativa L.) nanoemulsion gel. Int J Pharm Tech Res 2014;6:1162-9.

Leal LB, Cordery SF, Delgado-Charro MB, Bunge AL, Guy RH. Bioequivalence methodologies for topical drug products: In vitro and ex vivo studies with a corticosteroid and an anti-fungal drug. Pharm Res 2017;34:730-7.

Pimolphan P, Piyapan S, Porntip P, Wijit B, Benchaphorn L, Chayada K, et al. Proretinal nanoparticles: Stability, release, efficacy, and irritation. Int J Nanomed 2016;11:3277-86.

Khatab A, Ismail S. Formulation and evaluation of oxiconazole nitrate mucoadhesive nanoemulsion based gel for treatment of fungal vaginal infection. Int J Pharm Pharm Sci 2016;8:34-40.

Padula C, Colombo G, Nicoli S, Catellani PL, Massimo G, Santi P, et al. Bioadhesive film for the transdermal delivery of lidocaine: In vitro and in vivo behavior. J Control Release 2003;88:277-85.

Giongo JL, Vaucher RD, Ourique AF, Steffler MC, Frizzo CP, Hennemman B, et al. Development of nanoemulsion containing Pelargonium graveolens oils: Characterization and stability study. Int J Pharm Pharm Sci 2016;5:271-6.

Published

07-06-2019

How to Cite

DINANATH GAIKWAD, and NAMDEO JADHAV. “TERMINALIA ARJUNA TRANSDERMAL MATRIX FORMULATION CONTAINING DIFFERENT POLYMER COMPONENTS: TERMINALIA ARJUNA TRANSDERMAL MATRIX FORMULATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 12, no. 6, June 2019, pp. 266-70, doi:10.22159/ajpcr.2019.v12i6.32643.

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Original Article(s)