A CASE REPORT OF ZIDOVUDINE-INDUCED THUMBNAILS HYPERPIGMENTATION IN AN HIV POSITIVE PATIENT WITH SECONDARY HERPES ZOSTER OPHTHALMICUS INFECTION

Authors

  • TIRIN BABU Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • GEORGE MATHEW PANACHIYIL Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • JUNY SEBASTIAN Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
  • VEERANNA SHASTRY Department of Dermatology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i6.33050

Keywords:

Zidovudine,, Antiretroviral therapy,, Nail hyperpigmentation,, Human immunodeficiency virus

Abstract

Zidovudine is one of the first-line antiretroviral therapy regimen drug used to treat human immunodeficiency virus infected patients. Nail pigmentation associated with zidovudine therapy is seen in adults and children’s, mainly dark-skinned patients. This case attempts to draw attention among healthcare professionals concerning the non-serious adverse effect of nail pigmentation with zidovudine. In our case, the patient was counseled about this adverse effect without any change in zidovudine therapy. Even though this side effect is harmless and reversible, the psychological aspects of this visible side effect may reduce medication adherence and can also result in inessential investigations and management for misdiagnoses such as cyanosis and melanoma.

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Author Biography

JUNY SEBASTIAN, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

M.Pharm, Lecturer, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka – 570015, India

References

Tandon VR, Sadiq S, Khajuria V, Mahajan A, Sharma S, Gillani Z. Zidovudine-induced nail hyper-pigmentation in 45-year-old women

prescribed for HIV/tuberculosis co-infection. J Midlife Health 2016;7:38.

Onwubuya EI, Ukibe NR, Kalu OA, Ukibe SN, Obasi IJ. Assessment of kidney function, estimated glomerular filtration rate and body mass index in HIV seropositive subjects on antiretroviral therapy in Nnewi. Int J Pharm Pharm Sci 2018;10:44-9.

Roy H. Formulation and design of extended release matrix tablets of zidovudine hydrochloride: A study on effect of various grades of ethocel and hpmc. Int J Pharm Pharm Sci 2018;10:138.

Chawre SM, Pore SM, Nandeshwar MB, Masood NM. Zidovudineinduced nail pigmentation in a 12-year-old boy. Indian J Pharmacol

;44:801-2.

Fisher CA, McPoland PR. Azidothymidine-induced nail pigmentation. Cutis 1989;43:552-4.

Rahav G, Maayan S. Nail pigmentation associated with zidovudine: A review and report of a case. Scand J Infect Dis 1992;24:557-61.

Singh SK, Rai T. A case of zidovudine induced pigmentation on palms and soles. Indian Dermatol Online J 2014;5:98-9.

Furth PA, Kazakis AM. Nail pigmentation changes associated with azidothymidine (zidovudine). Ann Intern Med 1987;107:350.

Dereure O. Drug-induced skin pigmentation. Epidemiology, diagnosis and treatment. Am J Clin Dermatol 2001;2:253-62.

Published

07-06-2019

How to Cite

TIRIN BABU, GEORGE MATHEW PANACHIYIL, JUNY SEBASTIAN, and VEERANNA SHASTRY. “A CASE REPORT OF ZIDOVUDINE-INDUCED THUMBNAILS HYPERPIGMENTATION IN AN HIV POSITIVE PATIENT WITH SECONDARY HERPES ZOSTER OPHTHALMICUS INFECTION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 12, no. 6, June 2019, pp. 1-2, doi:10.22159/ajpcr.2019.v12i6.33050.

Issue

Section

Case Study(s)