ASSOSIATION OF SERUM MAGNESIUM LEVELS WITH HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON METFORMIN OR PIOGLITAZONE

Authors

  • HUWAINAN NISA NASUTION Department of Internal Medicine, Airlangga University, Surabaya, Indonesia.
  • SONY WIBISONO MUDJANARKO Department of Internal Medicine, Airlangga University, Surabaya, Indonesia.
  • DWI APRILAWATI Department of Public Health and Preventive Medicine, Airlangga University, Surabaya, Indonesia.
  • AGUNG PRANOTO Department of Internal Medicine, Airlangga University, Surabaya, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i6.33061

Keywords:

Homeostatic model assessment of insulin resistance,, Insulin resistance,, Serum magnesium levels,, Type 2 diabetes mellitus

Abstract

Background: Magnesium is known to be associated with insulin resistance in type 2 diabetes mellitus (DM) resulting in the accelerated progression of the disease causing the risk of complications in type 2 DM. In a hypomagnesemic state, there is a decrease in the phosphorylation of insulin receptor which leads to an increase in insulin resistance.

Methods: The inclusion criteria were the patients of type 2 DM who had already used metformin or pioglitazone with a body mass index of <30 kg/m2. An examination of magnesium nutrient intake on the patients was carried out with a validated food frequency questionnaire of nutrient intake for the past 3 days by a nutritionist. Fasting plasma glucose was analyzed using Roche/Hitachi Cobas C System. Fasting insulin was analyzed using the Elecsys and Cobas E Immunoassay Analyzers. Serum magnesium level was analyzed using Roche/Hitachi Cobas C 311/501 System.

Results: The study involved 41 subjects of patients with type 2 DM. The mean of magnesium nutrient intake was still low with an average of 207.2 ± 52.9 mg/day. The mean value of serum magnesium levels was 2.04 ± 0.19 mg/dl. The mean of homeostatic model assessment of insulin resistance (HOMA-IR) was 4.82 ± 5.66. The lower level of the serum magnesium had a significant correlation with HOMA IR.

Conclusion: The nutrient intake containing magnesium is lower than recommendation. There is a significant negative correlation between the magnesium level and HOMA-IR on type 2 DM on metformin or pioglitazone.

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Published

07-06-2019

How to Cite

HUWAINAN NISA NASUTION, SONY WIBISONO MUDJANARKO, DWI APRILAWATI, and AGUNG PRANOTO. “ASSOSIATION OF SERUM MAGNESIUM LEVELS WITH HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON METFORMIN OR PIOGLITAZONE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 12, no. 6, June 2019, pp. 63-66, doi:10.22159/ajpcr.2019.v12i6.33061.

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