A REVIEW ON NANOSPONGES A REVIEW ON NANOSPONGES: A BOON TO TARGETED DRUG DELIVERY FOR ANTICANCER DRUG

NIKITA SEHGAL; VISHAL GUPTA N; SANDEEP KANNA

doi:10.22159/ajpcr.2019.v12i7.33118

Authors

NIKITA SEHGAL Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
VISHAL GUPTA N Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
SANDEEP KANNA Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i7.33118

Keywords:

Nanosponges,, Cyclodextrin,, Antineoplastic, molecules

Abstract

In recent decades, the rise in the investigation of new drugs had made health-care system expensive compared to conventional drug delivery systems and techniques. The present drug delivery systems have become highly productive and are growing fast. Majority of the anticancer agent has low water solubility resulting in multistep synthetic routes that require higher selectivity and specificity that can cause difficulty in the development of the formulation. Nanosponges (NSs) are branched cyclodextrin (CD) polymeric systems which have proven to be a boon in the pharmaceutical and biomedical fields. Different kinds of NSs based on different types of CDs and crosslinkers are used for developing of new drug formulations from the past few years for various applications in health care. Nanotechnology has overcome the issues regarding the drug solubility, stability, and other parameters and has attained success in achieving of sustained release, increased activity, improved permeability, delivery of nucleoprotein, the stimuli-responsive release of the drug, and improved drug bioavailability. There is a huge eruption of research on NSs for cancer treatment. Multiple anticancer moieties have been developed, taking into account the pharmacological and physicochemical perspective of the drug to develop a NS formulation. Our target in this review is to catch an efficient and far-reaching NSs for malignancy cancer treatment announced until now. This survey will give a perfect stage for providing details for researchers taking a shot at using new polymers for improving the treatment of the disease using nanotechnology. The present article provides details regarding antineoplastic molecules and provides ideas on CD-based NSs specifically using curcumin, tamoxifen, resveratrol, quercetin, oxygen-NSs, temozolomide, doxorubicin, and 5-fluorouracil (5-FU), and erlotinib (ETB) glutathione.

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