EVALUATION OF LIVER AND LIPID PARAMETERS IN CHOLELITHIASIS
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i9.33694Keywords:
Cholelithiasis, Cholesterol, Serum glutamic oxaloacetate transaminase, Serum glutamic pyruvic transaminase, Alkaline phosphatase, BilirubinAbstract
Objectives: The objectives of the present study were to compare the biochemical parameters in gallstones patients and controls and to study the differences in their levels in male and female patients.
Methods: The patient data were collected from the Navpreet Hospital, Amritsar. All the demographic data and ultrasonographic features were noted in a pre-structured pro forma of cholelithiasis patients. The blood sample was collected in aseptic conditions and serum biochemical parameters of liver (serum glutamic oxaloacetate transaminase [SGOT] and serum glutamic pyruvic transaminase [SGPT]) and lipids (cholesterol and triglyceride) were investigated in the patients.
Results: In this study, it was found that cholelithiasis is more prevalent in females (76%) as compared to females (26%). The SGOT and SGPT levels were higher in 20–40 years age group females with a mean of 78±7.12 and 70±5.34 mg/dl, respectively. Alkaline phosphatase (ALP) level also increases in female patients with a mean of 106±5.36 mg/dl. Same pattern was observed for bilirubin and lipid levels.
Conclusion: The prevalence of gallstones was found more in females than males. Serum cholesterol, triglyceride, SGOT, SGPT and ALP, and bilirubin play a major contributing role in the formation of gallstone in females. Incidence of gallstones is most often correlated with dietary factors, obesity or overweight, sedentary lifestyle, eating high fat and cholesterol diet, eating low-fiber diet, having a family history of gallstones, and having liver disease.
Downloads
References
Charles F, Bruncicardi M, Thai H. Gallbladder and the extrahepatic biliary system. Schwartz Princ Surg 2009;8:1135-67.
Abdullah UY, Jassim HM, Baig AA, Khorsheed RM, Al-Khayat AM, Sulong AF, et al. Gallstones in patients with inherited haemolytic diseases. Int J Pharm Pharm Sci 2015;7:9-15.
Heiss G, Tamir I, Davis CE, Tyroler HA. The circulatory system. Circ J 1980;61:302.
Pani JP, Pandey MS, Pani DS, Maderakar MN, Katti HK. Estimation of predominate histologic alterations in cholecystitis and cholelithioasis of human gallbladder an analytical and statistical study through the approach of routine histochemistry. J Dent Med Sci 2013;6:35-43.
Meilstrup JW, Hopper KD. Imaging atlas of the normal gallbladder and its variants. J Gastroenterol Hepatol 1991;157:1205-08.
Guyton AC, John E. Assessment of gallstone predictor comparative analysis of ultrasonographic and biochemical parameters. Textbook Med Physiol 2005;11:802-4.
Nahrwold DL. The biliary system. In: Textbook of Surgery: The Biological Basis of Modern Surgical Practice. Vol. 15. USA: W.B. Saunders Company; 1997. p. 1117-35.
Ahmad NZ. Routine testing of liver function before and after elective laparoscopic cholecystectomy: Is it necessary? JSLS 2011;15:65-9.
Wallnofer H, Schmidt E, Schmidt FW. Determination of SGOT and SGPT by IFCC method. J Clin Biochem 1986;24:497-507.
Bessey OA, Brock MJ. Determination of ALP. Biol Chem 1946;164:321.
Jendrarrisk L, Grof P. Determination of bilirubin by DMSO Method. Clin Biochem 1983;2:29.
Roeschlau P, Bernt E, Gruber WA. Determination of cholesterol. Clin Biochem 1974;12:266.
Bergmeyer M, Schetter G. Determination of triglyceride by GPO-POD method. Clin Chem 1975;10:25.
Reshetnyak VI. Concept of the pathogenesis and treatment of cholelithiasis. World J Hepatol 2012;4:18-34.
Channa NA. Hypercholesterolemia in adults population of Pakistan. Pak Armed Forces Med J 2008;58:197.
Bose SM, Mazumdar A, Prakash VS, Kocher R, Katariya S, Pathak CM, et al. Evaluation of the predictors of choledocholithiasis: Comparative analysis of clinical, biochemical, radiological, radionuclear, and intraoperative parameters. Surg Today 2001;31:117-22.
Saraya A, Irshad M, Gandhi BM, Tandon RK. Plasma lipid profile in gallstone patients from North India. Trop Gastroenterol 1995;16:16-21.
Tandon RK, Saraya A, Paul S, Kapur BM. Dietary habits of gallstone patients in Northern India. J Clin Gastroenterol 1996;22:23-7.
Grigor’eva IN, Maliutina SK, Voevoda MI. Role of hyperlipidemia in cholelithiasis. Eksp Klin Gastroenterol 2010;(4):64-8.
Völzke H, Baumeister SE, Alte D, Hoffmann W, Schwahn C, Simon P, et al. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion 2005;71:97-105.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
