STUDIES ON GLUCOSE-LOWERING EFFICACY OF THE ACACIA SUMA ROXB. ROOT

JITENDRA DEBATA; SUNDEEP KUMAR HK

doi:10.22159/ajpcr.2019.v12i18.33787

Authors

JITENDRA DEBATA Department of Pharmaceutical chemistry, GNITC-School of Pharmacy, Ibrahimpatnam, Rangareddy, Telangana, India.
SUNDEEP KUMAR HK Department of Pharmaceutical chemistry, Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i18.33787

Keywords:

Acacia suma, Streptozotocin, Metformin, Hyperglycemic, Normoglycemic, Oral glucose tolerance test

Abstract

Objective: The objective of the study was to evaluate the glucose-lowering efficacy of the Acacia suma Roxb. (Family: Fabaceae) root extracts on Wister albino rats.

Methods: A. suma roots were shade dried, powdered, and extracted by Soxhlet extraction procedure using petroleum ether, chloroform, ethanol, and water. The acute toxicity studies were conducted on Swiss albino mice as per the OECD guidelines 423. The antidiabetic activity of extracts was evaluated on adult Wistar rats at dose levels of 100,200, and 400 mg/kg P.O, respectively each using normoglycemic,glucose-loaded and Streptozotocin-induced rats. Metformin (50 mg/kg) was used as a reference standard for activity comparison.

Results: Among the tested extracts, the ethanol extract was found to produce promising results that are comparable to that of the reference standard metformin.

Conclusion: The study established the scientific basis for the utility of this plant in the treatment of diabetes and justifies the use of the root of the plant for treating diabetes as suggested in folklore remedies.

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References

O’Keefe JH, Bell DS, Wyne KL, Haffner SM. Overview of Diabetes Mellitus, Diabetes Essentials. 2nd ed. New Delhi: Jaypee Brothers Medical Publisher Pvt. Ltd.; 2006.

Gupta A, Gupta V. Diabetic blindness: A major challenge J Indian Med Assoc 2000;98:772-5.

Chattopadhyay RR, Medha C, Das S, Basu TK. Hypoglycemic and antihyperglycemic effect of Gymnema sylvestre leaf extract in rats. Fitoterapia 1993;15:450-4.

Zhang X. Introduction WHO Monographs on Selected Medicinal Plants. 1st ed. Vol. 1. New Delhi: A.I.T.B.S. Publishers; 2005.

Kiritikar KR, Basu BD. Indian Medicinal Plants. Vol. 2. Allahabad: Lalit Mohan Basu; 1933. p. 935.

Anonymous. The Wealth of India. Vol. 1. New Delhi: CSIR; 1985. p. 42.

Vanpuyvelde L, Geysen D, Ayobangira FX, Hakizamunge E, Nshimiyimana A, Kalisa A. Screening for Asthma. J. Ecthnopharmacol 1985;13:209-15.

Headbarg O, Headberg PJ, Madati NK, Mshigeni EN, Mshiu GS. Inventory of plants used in traditional medicine in Tanzania. II. Plants of the families Dilleniaceae Opiliaceae. J. Ecthnopharmacol 1983;9:105-27.

Almagboul AZ, Bashir AK, Karim A, Salim M, Farouk A, Khalid SA. Antimicrobial activity of certain Sudanese plants used in folkloric medicine: Screening for antibacterial activity. Fitoterapia 1988;59:393-6.

Selvanayahgam ZE, Gnanevendhan SG, Balakrishna K, Rao RB. Antisnake venom botanicals from ethnomedicine. J. Herbs Spices Med Plants 1994;2:45-100.

Gessler MC, Nkunya MH, Mwasumbi LB, Heinrich M, Tanner M. Screening Tanzanian medicinal plants for antimalarial activity. Acta Trop 1994;56:65-77.

Watt JM, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. E+S. London: Livingstone Ltd.; 1962. p. 1455-7.

Massie Y, Nshimo CM. Screening for Abscesses and Sores.. East Afr Med J 1995;72:661-3.

Gandhi P. New proanthocyanidin from the stem bark of Acacia suma. Experientia 1977;33:1272.

Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants. Vol. 2. New Delhi: Central Drug Research Institute, Lucknow and Publications, and Information Directorate; 1933. p. 4-5.

Ayoub SM. Flavenol molluscicides from the Sudan Acacias. Int J Crude Drug Res 1985;23:87-90.

Acharyya S, Dash GK, Mondal S, Acharyya A, Dash SK. Studies on the hypoglycaemic activity of Acacia suma (Roxb.) barks. Int J Chem Anal Sci 2010;1:10-3.

Anonymous. Reviews on Indian Medicinal Plants. Vol. 1. New Delhi: ICMRV; 1963. p. 61.

Anonymous. OECD Guidelines for the Testing of Chemicals, Revised Draft Guidelines 423: Acute Oral Toxicity-Acute Toxic Class Method, Revised Document. Govt. of India: CPCSEA, Ministry of Social Justice and Empowerment; 2000.

Ganapaty S, Dash GK, Subburaju T, Suresh P. Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts. Fitoterapia 2002;73:28-31.

Shivhare Y, Dangi S, Soni P, Singh P, Baghel SS. Acute toxicity study of aqueous extract of Coccinia indica (Roots). Asian J Res Pharm Sci 2011;1:23-5.

Dash GK, Bal SK, Annapurna MM, Suresh P. Studies on the hypoglycaemic activity of Hemidesmus indicus R. Br. Roots. Pharmacogn Mag 2008;4:221-5.

Edwin E, Sheeja E, Dhanabal SP, Suresh B. Antihyperglycemic activity of Passiflora mollissima Bailey. Indian J Pharm Sci 2007;69:570-1.

Tiwari AK, Rao M. Diabetes mellitus and multiple therapeutic approaches of phytochemicals, present status, and future prospects. Curr Sci 2002;83:30-8.

Fischer LJ, Hamburger SA. Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase, and a metal chelator. Diabetes 1980;29:213-6.

Lenzen S. The mechanisms of alloxan and streptozotocin-induced diabetes. Diabetologia 2008;51:216-26.