FORMULATION AND EVALUATION OF METRONIDAZOLE TABLETS USING NATURAL GUM
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i6.33914Keywords:
Aloe vera,, Metronidazole,, BinderAbstract
Objectives: The objective of the present study was to formulate the metronidazole tablets using natural Aloe vera gum as binding agent.
Materials and Methods: To determine the binding properties of the extracted A. vera gum were used for the preparation of metronidazole tablets and compared with other binding agents such as acacia and sodium carboxymethyl cellulose (CMC). Physical properties such as hardness, friability, disintegration time, and in vitro dissolution rate are the important parameter which determines for each formulation. Three batches of metronidazole tablets are prepared using acacia (F1), sodium CMC (F2), and A. vera gum (F3) as binding agent.
Results: The granules were evaluated by determining the angle of repose (26.01 ± 0.110–27.18 ± 0.166°), bulk density, tapped density, Hausner ratio, and Carr’s index. It shows satisfactory results. At time 90 min, the percentage release of drug for F1, F2, and F3 was 44.947%, 31.467%, and 53.424%, respectively. The tablets prepared with A. vera gum showed faster release profile than other binders.
Conclusion: From the results, it was shown that tablets prepared with A. vera gum have good binding properties and also helped tablets for faster release.
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References
Shilpa PC, Pradeep SP. Pharmaceutical excipients: A review. Int J Adv Pharm Biol Chem 2012;1:21-34.
Das AS, Das S, Samanta A. Formulation and evaluation of controlled release floating capsules of ciprofloxacin HCL. Der Pharm Sin 2013;4:72-5.
Chukwu A. Studies on detarium microcarpium gum II. Investigation as a prolonged release matrix for encapsulated chlorpheniramine maleate. STP Pharma Sci 1994;4:399-403.
Disanto AR. Bioavailability and bioequivalency testing in remington. Sci Pract Pharm 1995;19:606.
Eichie FE, Amalime AE. Evaluation of the binder effects of the gum mucilages of Cissus populinea sand Acacia senegal on the mechanical properties of paracetamol tablets. Afr J Biotechnol 2007;19:2208-11.
Emeje M, Isimi C, Kunle O. Effect of Grewia gum on the mechanical properties of paracetamol tablet formulations. Afr J Pharm Pharmacol 2007;2:1-6.
Ibezim EC, Ofoefule SI, Omeje EO, Onyishi VI, Odoh UE. The role of ginger starch as a binder in acetaminophen tablets. Sci Res Essay 2008;3:46-50.
Jani JK, Shah DP, Jain VC, Patel MJ, Vithalan DA. Evaluating mucilage from Aloe barbadensis Miller as a pharmaceutical excipient for sustained release matrix tablets. Pharm Technol 2007;31:90-8.
Hamman JH. Composition and applications of Aloe vera leaf gel. Molecules 2008;13:1599-616.
Kotke MK, Chueh HR, Rodes CT. Comparison of disintegrant and binder activity of three corn starch products. Drug Dev Ind Pharm 1992;18:2207-23.
Prescott JK, Barnum RA. Powder flowability. Pharm Technol 2000;24:60-84.
Das S, Mandal P. Design, formulation, and evaluation of solid dispersion tablets of poorly water-soluble antidiabetic drug using natural polymer. Asian J Pharm Clin Res 2019;12:195-7.
Das S, Roy D. Formulation and evaluation of beta-cyclodextrin complex tablets of ibuprofen. Int J Pharm Res Health Sci 2016;4:1022 4.
Nag D, Das S, Samanta A. Formulation and evaluation of immediate release tablet of isoniazid and pyridoxine hydrochloride. World J Parm Pharm Sci 2015;4:1726-40.
Haritha B. A review on evaluation of tablets. J Formul Sci Bioavailab 2017;1:2-3.
Das S, Samanta A, Dey HS. Formulation, in vitro release kinetics and stability interpretation of sustained release tablets of metformin hydrochloride. Int J Pharm Pharm Sci 2015;7:418-22.
Okorie O, Oreh NC. Evaluation of Aloe barbadensis (Aloe Vera) gum as a binder in tablet formulation. Sci Afr 2010;9:119-25.
Adolfsson A, Caramella C, Nystrom C. The effect of milling and addition of dry binder on the inter-particulate bonding mechanisms in sodium chloride tablets. Int J Pharm 1998;160:187-95.
Ohwoavworhua FO, Ofoefule SI. Evaluation of disintegrant properties of microcrystalline cellulose obtained from Luffa cylindrical in aspirin based formulations. Afr J Pharm 2006;2:54-9.
Akin-Ajani OD, Itiola OA, Odeku OA. Effects of plantain and corn starches on the mechanical and disintegration properties of paracetamol tablets. AAPS PharmSciTech 2005;6:E458-63.
Odeku OA, Itiola OA. Effects of interacting variables on the tensile strength and the release properties of paracetamol tablets. Trop J Pharm Res 2003;2:147-53.
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