FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF MELOXICAM USING NATURAL SUPERDISINTEGRANTS
DOI:
https://doi.org/10.22159/ajpcr.2020.v13i2.34838Keywords:
Meloxicam, Banana powder, Solid dispersion (SD), Taste masking, Direct compressionAbstract
Objective: The objective of the present work was the preparation and evaluation of mouth dissolving tablets (MDTs) of meloxicam using natural superdisintegrants.
Methods: Meloxicam is BCS Class II (low soluble, and high permeable) drug increasing the dissolution properties of the poorly water-soluble drug meloxicam using a solid dispersion method (solvent evaporation method). Solvent evaporation method using drug and carrier as polyethylene glycol (PEG)-6000 and PEG-15,000 the ratio of 1:1, 1:2 (drug:carrier), and acetone as solvent. In house prepared banana powder were used as natural superdisintegrant. Manufacturing of MDT was done by the direct compression method. In this MDTs, various excipients were used such as mannitol used as the diluent, sodium saccharin used as a sweetening agent, Avicel pH-102 used as a binding agent, and talc and sodium lauryl sulfate (SLS) used as lubricant and glidant. The best formula of the tablet was selected according to the disintegration time (DT) and friability tests.
Results: The results have shown that an increase in the meloxicam solubility was obtained using solid dispersion with the solvent evaporation method using PEG-15000 as a carrier in the ratio of 1:2 (drug:carrier). Taste masking was also done by a solid dispersion method. Tablet prepared with in house prepared banana powder gave less DT (70 s) as compared to tablet prepared with branded banana powder (80 s), but formulation F5 failed in friability testing. Improved strength of tablet obtained using SLS (<1%) also showed an increase in the dissolution performance of the tablet in formulation F6. This F6 formulation having 10% natural super disintegrating agent (in house prepared banana powder) has shown 99% cumulative drug release within 18 min. It also passed the friability test.
Conclusion: Accordingly, the solubility of meloxicam was successfully enhanced through solid dispersion with carrier PEG-15,000 and formulated as a MDT to improve its oral absorption. PEG has also been used as a taste masking agent in these formulations. It was concluded that in house banana powder had excellent DT as compared to branded banana powder. Banana powder is “economical” and “easily available” than other commonly used synthetic superdisintegrants. The process of banana powder preparation is eco friendly. The meloxicam MDT formulated with natural superdisintegrant in house prepared banana powder found to pass all pharmacopeial tests.
Downloads
References
Suryadevara V, Lankapalli SR, Danda LH, Pendyala V, Katta V. Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets. Integr Med Res 2017;6:280-91.
Chauhan V, Kumar K, Teotia D. Fast dissolving tablets: A promising approach for drug delivery. Univ J Pharm Res 2017;58-64.
Hirani JJ, Rathod DA, Vadalia KR. Orally disintegrating tablets: A review. Trop J Pharm Res 2009;8:161-72.
Kalia A, Khurana S, Bedi N. Formulation and evaluation of mouth dissolving tablets of oxcarbazepine. Int J Pharm Pharm Sci 2009;1:12-3.
Sukhavasi S, Kishore VS. Natural superdisintegrants: Changed scenario and latest advances. JPTFT 2019;4:1-5.
Savjani KT, Gajjar AK, Savjani JK. Drug solubility: Importance and enhancement techniques. ISRN Pharm 2012;2012:1-11.
Hassan M, Dehghana G, Jafar M. Improving dissolution of meloxicam using solid dispersions. Iran J Pharm Res 2006;5:231-8.
Amina MA, Myasar MA, Ahlam AK. Preparation and evaluation of meloxicam solid dispersions by solvent evaporation method. Int Res J Pharm 2014;5:838-45.
Patel UJ, Patel PJ, Prajapati HB, Patel RJ. Studies on solubility of meloxicam by solid dispersion method. J Pharm Res 2012;5:2290-2.
Dhahir RK, Al-Kotaji M. Formulation of orally disintegrating tablets of cinnarizine by using direct compression method. Int J Appl Pharm 2018;11:117-23.
Sreenivas SA, Gadad A, Patil M. Formulation and evaluation of ondansetron hydrochloride directly compressed mouth dissolving tablets. Indian Drugs 2006;4:35-7.
Arti M, Sangeetha G. In vitro in vivo evaluation of fast-dissolving tablets containing solid dispersion of oxcarbazepine. Int J Pharm Pharm Sci 2016;8:124-31.
Shirke SH, Shewale SB, Kulkarni AS, Aloorkar NH. Solid dispersion: A novel approach for poorly water soluble drugs. Int J Curr Pharm Res 2015;7:1-8.
Momin M, Rathod S, Kar S. Taste masking techniques for bitter drugs-an overview. Int J Pharm Technol 2012;4:2100-18.
Sharma S, Lewis S. Taste masking technologies: A review. Int J Pharm Pharm Sci 2010;2:1-8.
Wagh VD, Ghadlinge SV. Tastemasking methods and technologies in oral pharmaceuticals: Current perspectives. J Pharm Res 2009;2:1049-54.
Bharathi A, Khaleel S, Deepthi BK, Phanindra MC. Formulation and evaluation of telmisartan orodispersible tablets by using banana powder. Indian J Res Pharm Biotechnol 2014;2:982-7.
Karumuri K, Kumaran A, Nagalingam A. Comparative study of natural and synthetic superdisintegrants in the formulation of oral disintegrating tablets using bambuterol hydrochloride as model drug. Indo Am J Pharm Res 2013;7:7421-30.
de los Santos CJ, Perez-Martínez JI, Gomez-Pantoja ME, Moyano JR. Enhancement of albendazole dissolution properties using solid dispersions with gelucire 50/13 and PEG 15000. J Drug Delivery Sci Technol 2017;42:1-12.
Oliveira CP, Ribeiro ME, Ricardo NM, Souza TV, Moura CL, Chaibundit C, The effect of water-soluble polymers, PEG and PVP, on the solubilisation of griseofulvin in aqueous micellar solutions of pluronic F127. Int J Pharm 2011;421:252-7.
Jain C, Naruka P. Formulation and evaluation of fast dissolving tablet of valsartan. Int J Pharm Pharm Sci 2009;1:219-26.
Raj A. Comparative evaluation of potato starch and banana powder as a disintegrating agents in aceclofenac tablet formulation. Int J Pharm Pharm Sci 2013;5:204-7.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
