EFFECT OF NOISE STRESS-INDUCED NEUROBEHAVIORAL CHANGES ON WISTAR ALBINO RATS

ARCHANA ARJUNAN; RAVINDRAN RAJAN

doi:10.22159/ajpcr.2019.v12i10.34843

Authors

ARCHANA ARJUNAN Department of Physiology, Dr. ALM PG IBMS, University of Madras, Chennai, Tamil Nadu, India.
DR. RAVINDRAN RAJAN Department of Physiology, Dr. ALM PG IBMS, University of Madras, Chennai, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i10.34843

Keywords:

Cognition, Learning, Noise, Stress, Neurodegenerative disease, Social interaction

Abstract

Objective: The study aims to investigate the effect of acute noise stress on cognitive functions in male Wistar albino rats.

Methods: Adult albino rats were randomly divided into two groups. Each group contains six animals. Rats exposed to acute noise stress (100 dB/4 h) were compared with control animal and assessed for cognition using T-maze, hole-board test, open-field test, marble burying test, and social interaction behavior.

Results: The rats exposed to acute noise stress showed the significance (p<0.05) of behavioral alterations such as impaired learning and memory, memory retention, increased fear and anxiety, obsessive–compulsive behavior, social avoidance, and decreased social interaction.

Conclusion: The results report that acute noise stress affects the cognition, and it became chronic may confer the increased risk of neurodegenerative disorders.

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