NIGELLA SATIVA OIL AS AN ADD-ON IN THE CONSERVATIVE MANAGEMENT OF DIABETIC NEPHROPATHY: A NOVEL SYNERGISTIC APPROACH

MOHD ASHRAF ALAM; MOHAMMAD NASIRUDDIN; SHAHZAD F HAQUE; RAHAT A KHAN

doi:10.22159/ajpcr.2019.v12i10.34985

Authors

MOHD ASHRAF ALAM Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
MOHAMMAD NASIRUDDIN Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
SHAHZAD F HAQUE Department of Medicine, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
RAHAT A KHAN Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i10.34985

Keywords:

end-stage renal disease, diabetic nephropathy, diabetes mellites, chronic kidney disease, glomerular filtration rate,, alpha keto analogue, Nigella sativa oil

Abstract

Objective: The objective of the study was to evaluate efficacy and safety Nigella sativa oil as an add-on therapy in addition to alpha-keto analog of essential amino acids in patients diabetic nephropathy (DN).

Methods: The study was conducted in a tertiary care center of North India on patients of DN. It was a prospective, comparative, and open labeled study. Patients were randomly divided into two interventional groups. Group I (control) received conservative management of chronic kidney disease consisting of alpha-keto analog (600 mg tab. 3 times a day), while Group II (test) received conservative management along with alpha-keto analog and N. sativa oil (2.5 ml, per orally, once daily) for 12 weeks. Hemogram and renal function, serum electrolytes tests were done, and adverse events were recorded at baseline, 4, 8, and 12 weeks of treatment.

Results: After 12 weeks of treatment, there was a marked improvement in clinical features and biochemical parameters in both the control and test groups, but it was more statistically significant in the test group as compared to control group especially in renal function (p≤0.05). Both groups showed steady improvement in the biochemical parameters as compared to their pre-treated values which were more marked in N. sativa oil supplemented group. There was a reduction in blood glucose, blood urea, serum creatinine, and 24-h total urine protein, and an increase in hemoglobin, 24-h total urine volume, and glomerular filtration rate.

Conclusion: N. sativa oil supplementation along with alpha-keto analog is more efficacious and safer in delaying the progression of disease patients of DN.

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Author Biographies

MOHAMMAD NASIRUDDIN, Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Pharmacology, Professor And Chairman

SHAHZAD F HAQUE, Department of Medicine, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

MEdicine, Professor

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