DEVELOPMENT, EVALUATION, AND CHARACTERIZATION OF LOSARTAN POTASSIUM BUCCAL PATCHES USING JACKFRUIT POLYMER: BUCCAL PATCH

SOJI S; ARUN JL

doi:10.22159/ajpcr.2019.v12i11.35323

Authors

SOJI S Department of Pharmaceutics, Malik Deenar College of Pharmacy, Kasaragod, Kerala, India.
ARUN JL Department of Pharmaceutics, The Dale View College of Pharmacy and Research Centre, Thiruvananthapuram, Kerala, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i11.35323

Keywords:

Buccal patches, Jackfruit polymer, Solvent casting

Abstract

Objective: The objective was to develop buccal patches of an antihypertensive drug and losartan potassium using jackfruit polymer for sustained buccal delivery.

Methods: The patches were prepared by the solvent casting method. Five formulations were developed with varying concentrations of jackfruit polymer. USP type II apparatus was used to perform in-vitro release study under perfect sink condition. Buccal formulations were developed to a satisfactory level in terms of drug release, bioadhesive strength, content uniformity, moisture content, surface pH, thickness, and stability study.

Results: From the results obtained F5 was found as best formulation, having appropriate folding endurance greater than 300, moisture content of 1.14±0.03 percentage (%), moisture uptake of 6.21±0.12%, swelling index (62.78%), bioadhesion strength (37.62±0.25 g), and bioadhesion time of 9 h 5 min. Fourier-transform infrared spectroscopy studies have shown no interactions between drug and polymer. All the formulations followed zero-order kinetics.

Conclusion: It can be concluded that mucoadhesive buccal patches of losartan potassium using jackfruit polymer are an auspicious dosage form to prolong the release of drug and enhance its poor oral bioavailability.

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References

Parmar HG, Jain JJ, Patel TK, Patel VM. Buccal patch: A technical note. Int J Pharm Rev Res 2010;4:178-82.

Sabry SA. Sodium cromoglycate mucoadhesive buccal patches: Design, fabrication, in vitro and in vivo characterization. Int J Appl Pharm 2018;10:76-82.

Sanghi DK, Tiwle R. An overview on buccal drug delivery system. Int J Pharmacother 2015;5:8-16.

Baveja SK, Rao KV, Arora J. Examination of natural gums and mucilages as sustaining materials in tablet dosage forms. Indian J Pharm Sci 1988;50:89-92.

Singh S, Bothara S. Development of oral mucoadhesive tablet of losartan potassium using natural gum from Manilkara zapota seeds. Int J Pharm Sci Nanotechnol 2015;6:1-15.

Joshi Y, Chandrul KK. Effect of storage on the drug release of tablet formulations prepared by novel plant mucilage’s as binding agent. Indo Am J Pharm Res 2015;5:3324-37.

Rao TR, Hussain MA, Bharathi C, Shilpa A, Anjum M. Bioadhesive polymer buccal tablets for losartan potassium controlled delivery: Formulation, in-vitro and ex-vivo evaluation. Am J Adv Drug Deliv 2015;3:1-10.

Chemate SZ, Priyanka SB. Formulation and evaluation of losartan potassium bi-layer buccal tablet using mucoadhesive polymer. Int J Pharm Sci Res 2017;8:2624-30.

Ajanta R, Chandra S, Parthiban KG, Kante NR, Sandeep D. Development and in vitro evaluation of buccoadhesive tablets of losartan potassium. Int Res J Pharm 2012;3:277-81.

Bulhe PJ, Mahajan SK, Ghule PJ. Formulation and evaluation of buccal patches by using natural gum. Int J Res Pharm Chem 2016;6:684-95.

Roda A, Prabhu P, Dubey A. Design and evaluation of buccal patches containing combination of hydrochlorothiazide and atenolol. Int J Appl Pharm 2018;10:105-12.

Shivane P, Solanki D. Formulation and evaluation of mucoadhesive buccal patch of timolol maleate. Am J Pharm Tech Res 2017;7:335-48.

Attama A, Akpa PA, Onugwu LE, Igwilo G. Novel buccoadhesive delivery system of hydrochlorothiazide formulated with ethyl cellulose hydroxypropyl methylcellulose interpolymer complex. Sci Res Essays 2008;3:26-33.

Kaur A, Kaur G. Mucoadhesive buccal patches based on interpolymer complexes of chitosan-pectin for delivery of carvedilol. Saudi Pharm J 2012;20:21-7.

Muthumanikandar RV, Edavalath S, Mukerghee R, Shan M. Development and in vitro evaluation of buccoadhesive tablets of losartan potassium. J Pharm Res 2011;4:1751-3.

Patel VM, Prajapati BG, Patel MM. Design and characterization of chitosan-containing mucoadhesive buccal patches of propranolol hydrochloride. Acta Pharm 2007;57:61-72.

Thombre SK, Gaikwad SS. Design and development of mucoadhesive buccal delivery for pantoprazole with stability enhancement in human saliva. Int J Pharm Pharm Sci 2013;5:122-7.

Raparla R, Chowdary YA, Thatipamula S. Formulation and evaluation of mucoadhesive buccal tablets of candesartan. Am J Adv Drug Deliv 2013;1:369-86.

Ahuja M, Kumar S, Kumar A. Evaluation of mucoadhesive potential of gum Cordia, an anionic polysaccharide. Int J Biol Macromol 2013;55:109-12.