STUDY ON THE ASSOCIATION OF OBESITY INDICES WITH INFLAMMATORY MARKERS IN PRE-DIABETES AND DIABETES

PRADEEP KUMAR; SHAILAZA SHRESTHA; MAHENDRA PRASAD; PREETI SHARMA; MOHIT

doi:10.22159/ajpcr.2019.v12i12.35588

Authors

PRADEEP KUMAR Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
SHAILAZA SHRESTHA Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
MAHENDRA PRASAD Department of Biochemistry, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India.
PREETI SHARMA Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
MOHIT Department of Biochemistry, Autonomous State Medical College and Hospital, Basti, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i12.35588

Keywords:

Obesity, Inflammation, Pre-diabetes, Diabetes

Abstract

Objective: In this study, the main objective was to evaluate the association of markers of obesity with the inflammatory markers in pre-diabetes and diabetes.

Methods: This study recruited 300 participants (100 control group, 100 pre-diabetic group, and 100 diabetic group). The anthropometric variables such as body mass index (BMI), waist-hip ratio (WHR), and waist circumference (WC), and biochemical variables such as fasting blood glucose, glycated hemoglobin, uric acid, C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), and adiponectin were analyzed in each participant by standard methods.

Results: The present study documented significantly high values of BMI and WHR in patient (pre-diabetic and diabetic) groups compared to the control group. Similarly, the level of adiponectin decreased and that of uric acid, CRP, fibrinogen, and IL-6 increased significantly. Both BMI and WC were correlated significantly with inflammatory mediators in diabetic patients. The correlation with adiponectin was negative. In the pre-diabetic group, a significant correlation was observed only between WHR, adiponectin, and uric acid.

Conclusion: This study supports the fact that obesity-induced systemic inflammation of low grade is significantly associated with pre-diabetes and diabetes, thereby keeping these individuals at high risk of future complications especially cardiovascular diseases.

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Author Biography

PRADEEP KUMAR, Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.

Asst.Professor, Department of Biochemistry.

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