ANTITUMOR AND GASTROPROTECTIVE SCREENING OF SOME NOVEL ORGANIC DERIVATIVES OF BISMUTH

DIPTI MANI TRIPATHI; RAVI KANT; KRISHNA SRIVASTAVA

doi:10.22159/ajpcr.2020.v13i5.36622

Authors

DIPTI MANI TRIPATHI Department of Chemistry, Faculty of Chemical Sciences, Shri Ramswaroop Memorial University, Lucknow, Uttar Pradesh India.
RAVI KANT Department of Chemistry, Faculty of Chemical Sciences, Shri Ramswaroop Memorial University, Lucknow, Uttar Pradesh India.
KRISHNA SRIVASTAVA Department of Chemistry, Faculty of Chemical Sciences, Shri Ramswaroop Memorial University, Lucknow, Uttar Pradesh India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i5.36622

Keywords:

Organobismuth, Antitumor, Antiulcer, Gastroprotective activity

Abstract

Objectives: The objectives of present manuscript are to synthesize some new organic derivatives of bismuth having general formula (RBiL2; wherein R = C6F5; L = Substituted aromatic carboxylic acid), and characterized with the help of M.P., elemental, I.R., and NMR spectral analysis to ascertain the structure of novel compounds. These compounds were also characterized for their in vitro antitumor activity against human breast (MCF-7) and mammary cancer (EVSA-7) cell line along with gastroprotective (anti-ulcer) activity in rats using standard methods.

Methods: All the newly organobismuth having general formula (RBiL2) were synthesised by earliar reported methods especially using redistribution and complexation reactions. The in-vitro antitumor and gastroprotective studies were performed by using standard protocols and methods.

Results: It was found that the compounds were crystalline solids, air stable, and soluble in common organic solvent, have sharp melting points, and possess trigonal/pyramidal structure, exhibit higher activity than the standard ranitidine when the tests were carried out with aspirin induced and moderate activity was seen when the tests were done with ethanol induced along with potential antitumor activity against MCF-7 and EVSA-7 cell lines.

Conclusion: The newly synthesized organobismuth complexes were characterized to ascertain their structure by sophisticated instrumental and spectral analysis resulted as trigonal/pyramidal structure. The compounds were also screened 1st time for gastroprotective and antitumor activity in vitro. The observations clearly indicate that organobismuth carboxylates as reported here show potential gastroprotective and antitumor activity in vitro.

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References

Singh S, Hasan SM, Kant R. An overview of chemical properties and pharmacological importance of organobismuth compounds. Chron Pharm Sci 2018;2:35-45.

Rani P, Gupta P, Kant R. Biomedicinal aspects of group-15 elements (As, Sb, Bi). Int J Chem Res 2017;9:201-8.

Rani P, Gupta P, Kant R. Synthesis, characterization and biological screening of some novel complexes of group 15 elements (As, Sb, Bi). Int J Microbiol Res 2017;9:984-6.

Rani P, Gupta P, Kant R. Synthesis and characterization of some novel complexes of fluorobenzoic acid with group-15 elements (As, Sb, Bi) for antimicrobial and antitumor studies. Int J Drug Discov 2017;8:250-3.

Gupta P, Rani P, Kant R. Antimicrobial studies of some novel organobismuth compounds. Int J Microbiol Res 2018;10:773-5.

Gupta P, Rani P, Kant R. Synthesis, characterization and antimicrobial studies of novel organobismuth (III) complexes. Int J Microbiol Res 2018;10:1086-9.

Soni KK, Kant R, Kumar A. Synthesis and characterization of novel organobismuth compounds: Antimicrobial and antitumor studies. Int J Chem Res 2015;7:159-63.

Soni KK, Kant R, Kumar A. Biomedicinal and gastroprotective studies of some fluorine based diorganobismuth (III) compounds. Int J Chem Res 2016;8:168-72.

Tripathi DM, Amresh G, Kant R. Bio-medicinal studies of some new triorganobismuth (V) compounds. Int J Chem Res 2012;4:110-3.

Tripathi DM, Amresh G, Kant R. Antimicrobial and antitumor studies of some organic derivatives of bismuth. J Med Chem Lett 2011;1:1-6.

Tiwari VK, Shukla SK, Chauhan VS, Kant R, Rani S, Tewari IC. Antimicrobial, antitumor and gastro protective studies of some new water soluble organic derivatives of bismuth. Int J Pharma Anal 2010;2:9-14.

Chauhan VS, Tiwari VK, Shukla SK, Rani S, Mishra SN, Kant R, et al. Biological activity of some organic derivatives of bismuth. Int J Biotechnol Res 2009;2:67-71.

Kant R, Srivastava K, Singh S, Hasan SM, Srivastava J. Organobismuth Compounds for Medical Applications and Preparation Methods Thereof. New Delhi: Indian Patent; 2018.

Srivastava K, Kant R. Novel Antitumor Organobismuth Compound and Method of Preparation Therof. New Delhi: Indian Patent; 2019.

Chandrasekhar K, Behl HM, Sidhu OP, Ch VR, Pushpangadan P, Kant R, et al. A Novel Compound as Insecticidal and its Processing. United States: PCT (Global) Patent; 2006.

Singhal K, Kant R, Goswami AK, Raj P. Synthesis and characterization of bis (pentafluorophenyl) antimony (V) cations [(C6F5)2SbL3]3+. J Flourine Chem 2003;122:229-32.

Kant R, Amresh G, Chandrashekar K, Shukla SK. Biological studies of some perfluorophenyl antimony compounds. Phosphorus Sulfur Silicon Relat Elem 2009;184:2453-64.

Amresh G, Husain Z, Gupta RJ, Kant R, Rao CV, Singh PN. Gastro-protective effects of ethanolic extract from Cissampelos pareira in experimental animals. J Nat Med 2007;61:323-8.