PHYTOCHEMISTRY SCREENING AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN KARO TRADITIONAL OIL, AN INDONESIAN TRADITIONAL HERBAL MEDICINE

NOVA PRIMADINA; ACHMAD BASORI; DAVID S PERDANAKUSUMA

doi:10.22159/ajpcr.2020.v13i2.36736

Authors

NOVA PRIMADINA Department of Airlangga University, Surabaya, Indonesia.
ACHMAD BASORI Department of Pharmacology, Airlangga University, Surabaya, Indonesia.
DAVID S PERDANAKUSUMA Department of Plastic Surgery, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i2.36736

Keywords:

Traditional medicine, Indonesia traditional medicine, Phytochemistry screening, Gas chromatography-mass spectrometry, Karo oil, Karo traditional oil, Wound healing

Abstract

Objective: The purpose of this research was to observe the bioactive compounds of Karo traditional oil by phytochemistry screening and gas chromatography-mass spectrometry (GC-MS) analysis. Alkaloid,

Results: Terpenoid and flavonoid compounds were found, and no polyphenol compound from phytochemistry screening and 16 constituents were identified from the GC-MS analysis, α-pinene was found as the major component (74.47%), delta-3-carene (9.62%), 1% of octane, dodecane, camphor, undecane, isodecane, sabinene, hexadecane, nonane, and <1% tridecane, cyclohexane, pentacosane, heptadecan, limonene, and camphene.

Conclusion: Karo traditional oil works as a potent anti-inflammation at the inflammation phase of the wound healing process by suppressing the pro-inflammatory cytokines and promote anti-inflammatory cytokines.

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Author Biography

DAVID S PERDANAKUSUMA, Department of Plastic Surgery, Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia.

Lecturer of Plastic Surgery Department of Airlangga University - dr.Soetomo Hospital Surabaya – Indonesia
Vice dean of Medical Faculty, Airlangga University

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