• BIBHU PRASAD BEHERA Department of Internal Medicine, Saheed Laxman Naik Medical College and Hospital, Koraput, Odisha, India.
  • Manoranjan Dash Department of Chest and TB, Saheed Laxman Naik Medical College and Hospital, Koraput, Odisha, India.



Cirrhosis, Anemia, Thrombocytopenia, Alcoholic, Non-alcoholic


Objective: Efforts can be made to normalize the hematological parameters so that the morbidity and mortality in these patients could be effectively reduced.

Methods: This observational study was carried out among 69 cirrhosis patients that fulfills the inclusion and exclusion criteria, attended the medicine outpatient department, and admitted in medicine ward of PRM Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India, from June 2018 to January 2019.

Results: In our study, we had 59 male and 10 female patients with an average age of 49.8±13.19 years. About 92.75% of the patients were alcoholic. Abdominal distension (92.75%) and ascites (84.06%) were the most common presenting complaints. Pallor was present in 42 (60.87%) cases. Splenomegaly was present in 35 (50.72%) cirrhotic patients. Renal dysfunction was present in 23 (33.33%) cases. Sixty-six (95.65%) patients had anemia and 47 (68.12%) patients had thrombocytopenia.

Conclusions: From this study, we can conclude that, in cirrhosis of liver patients, various hematological changes are very common which need to be identified and corrected early to reduce morbidity and mortality.


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Melato M, Sasso F, Zanconati F. Liver cirrhosis and liver cancer. A study of their relationship in 2563 autopsies. Zentralbl Pathol 1993;139:25-30.

Graudal N, Leth P, Mårbjerg L, Galløe AM. Characteristics of cirrhosis undiagnosed during life: A comparative analysis of 73 undiagnosed cases and 149 diagnosed cases of cirrhosis, detected in 4929 consecutive autopsies. J Intern Med 1991;230:165-71.

Lim YS, Kim WR. The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis 2008;12:733-46.

Mathers C, Lopez A, Murray C. The burden of disease and mortality by condition: Data, methods, and results for 2001. In: Lopez A, Mathers C, Ezzati M, Jamison DT, Murray CJ, editors. Global Burden of Disease and Risk Factors. Washington, DC: Oxford University Press and the World Bank; 2006. p. 45-93.

Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study. Lancet 1997;349:1498-504.

Ashraf S, Naeem S. Frequency of hypersplenism in chronic liver disease patients presenting with pancytopenia. Spec Ed Ann 2010;16:108-10.

Khare S, Garg VK, Jain HK, Jatav O. To study hematological profile in patients of chronic liver disease. Int J Multidiscip Res Dev 2015;2:378-81.

Ballard HS. The hematological complications of alcoholism. Alcohol Health Res World 1997;21:42-52.

Shittu BT, Shittu MO, Oluremi AS, Orisadare O, Osemeke J, Lateef B. Thrombocytopenia and prolonged prothrombin time in neonatal septicemia. J Med Sci Clin Res 2014;2:1213-21.

World Health Organization. Hemoglobin Concentrations for the Diagnosis of Anemia and Assessment of Severity. Vitamin and Mineral Nutrition Information System (WHO/NMH/NHD/MNM/11.1). Geneva: World Health Organization; 2011. Available from: http://www. [Last accessed on 2019 Dec 24].

Suthar HN, Suthar KD, Mewada BN. Clinical profile of cases of alcoholic liver disease. Int J Med Sci Public Health 2013;2:394-8.

Sarin SK, Dhingra N, Bansal A, Malhotra S, Guptan RC. Dietary and nutritional abnormalities in alcoholic liver disease: A comparison with chronic alcoholics without liver disease. Am J Gastroenterol 1997;92:777-83.

Pathak OK, Paudel R, Panta OB, Pant HP, Giri BR, Adhikari B. Retrospective study of the clinical profile and prognostic indicators in patients of alcoholic liver disease admitted to a tertiary care teaching hospital in Western Nepal. Saudi J Gastroenterol 2009;15:171-5.

Mendenhall CL. Alcoholic hepatitis. Clin Gastroenterol 1981;10:417-41.

Hegde S, Vishnar A, Ramteke GB. Study of clinical and laboratory profile in alcoholic liver disease with emphasis on renal function. Int J Res Med Sci 2015;3:446-50.

Gonzalez-Casas R, Jones EA, Moreno-Otero R. Spectrum of anemia associated with chronic liver disease. World J Gastroenterol 2009;15:4653-8.

Kujovich JL. Hemostatic defects in end stage liver disease. Crit Care Clin 2005;21:563-87.



How to Cite

BEHERA, B. P., and M. Dash. “AN OBSERVATIONAL STUDY OF CLINICAL AND HEMATOLOGICAL PROFILE OF CIRRHOSIS OF LIVER”. Asian Journal of Pharmaceutical and Clinical Research, vol. 13, no. 4, Apr. 2020, pp. 149-52, doi:10.22159/ajpcr.2020.v13i4.36862.



Original Article(s)