EFFECTS OF TELMISARTAN ON PLASMA INTERLEUKIN-6 AND C-REACTIVE PROTEIN LEVELS IN MONOSODIUM GLUTAMATE-INDUCED OBESITY IN WISTAR ALBINO RATS

VENKATESH KM; SRIRAM BS; RAVICHANDRA V; RAJENDRA HOLLA

doi:10.22159/ajpcr.2020.v13i6.37286

Authors

VENKATESH KM Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Karnataka, India.
SRIRAM BS Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Karnataka, India.
RAVICHANDRA V Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Karnataka, India.
RAJENDRA HOLLA Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i6.37286

Keywords:

Monosodium glutamate, Telmisartan, Interlukin-6, C-reactive protein

Abstract

Objectives: The objectives of this study were to evaluate the effects of telmisartan on plasma interleukin (IL)-6 and C-reactive protein (CRP) levels in monosodium glutamate (MSG)-induced obesity in Wistar albino rats.

Methods: MSG at the dose of 500 mg/kg body weight is dissolved in distilled water and administered for 22 days. On the 9th day, telmisartan 7.5 mg/kg body weight is administered. After completion of experiment, body weight and biochemical parameters such as plasma IL-6 and CRP levels are measured using enzyme-linked immunosorbent assay.

Results: Telmisartan significantly decreased plasma IL-6 and CRP levels in MSG-treated obese rats.

Conclusion: Telmisartan, probably through its peroxisome proliferator-activated receptor-γ agonistic activity, produces significant anti-obesity effects in rats and may help in treating obese patients with metabolic syndrome.

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