A REVIEW ON THERAPEUTIC POTENTIAL OF HETEROCYCLIC PYRIMIDINE DERIVATIVES AS POTENT ANTIVIRAL AGENTS
Keywords:Pyrimidine, Anti-viral, Anti-inflammatory, Antibacterial, Anticancer, Antiviral
Pyrimidine nucleus exhibited remarkable pharmacological activities. The review of an article indicates that the compounds having pyrimidine nucleus have a wide range of therapeutic uses that include antiviral, anti-inflammatory, antibacterial, anticancer, antiviral, anti-HIV, antihypertensive, sedatives and hypnotics, anticonvulsant, and antihistaminic. This review article is intended to describe the antiviral activity of a compound containing the pyrimidine nucleus. The chemistry of pyrimidine is a thriving field for the study of their pharmacological uses. Numerous methods for the synthesis of pyrimidine as also their diverse reactions offer enormous scope in the field of medicinal chemistry. The review article aims to reveal the work reported on the antiviral synthetic pyrimidine compound and the chemistry and biological activities of pyrimidine during the past few decades. During this review article, we are mainly focusing the viral activities in different derivatives of pyrimidine nucleus. Therefore, we are going to discuss some important issues such as the good ideas to resist our increasing viral disease and the importance of a pyrimidine nucleus in the viral drugs. Hence, these are the main things we are going to discuss in this article.
Wagstaff AJ, Faulds D, Goa KL. Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1994;47:153-205.
Elion GB. Acyclovir: Discovery, mechanism of action, and selectivity. J Med Virol 1993;1:2-6.
Gilbert C, Bestman-Smith J, Boivin G. Resistance of herpesviruses to antiviral drugs: Clinical impacts and molecular mechanisms. Drug Resist Updat 2002;5:88-114.
Wagstaff AJ, Faulds RA, Weiss P, Ritz RF. Acyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdose. Am J Med 1993;94:212-5.
Elion GB, Furman PA, Fyfe JA, Miranda P, Beauchamp L, Schaeffer HJ. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci USA 1977;74:5716-20.
Lowance D, Neumayer HH, Legendre CM, Squifflet JP, Kovarik J, Brennan PJ, et al. Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation. International valacyclovir cytomegalovirus prophylaxis transplantation study group. N Engl J Med 1999;340:1462-70.
Ormrod D, Scott LJ, Perry CM. Valaciclovir: A review of its long term utility in the management of genital herpes simplex virus and cytomegalovirus infections. Drugs 2000;59:839-63.
Kalil AC, Freifeld AG, Lyden ER, Stoner JA. Valganciclovir for cytomegalovirus prevention in solid organ transplant patients: An evidence-based reassessment of safety and efficacy. PLoS One 2009;4:e5512.
Crumpacker CS. Ganciclovir. N Engl J Med 1996;335:721-9.
Wagstaff AJ, Bryson HM. Foscarnet. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with viral infections. Drugs 1994;48:199-226.
Deray G, Martinez F, Katlama C, Levaltier B, Beaufils H, Danis M, et al. Foscarnet nephrotoxicity: Mechanism, incidence and prevention. Am J Nephrol 1989;9:316-21.
Safrin S, Cherrington J, Jaffe HS. Clinical uses of cidofovir. Rev Med Virol 1997;7:145-56.
Lagoja IM. Pyrimidine as constituent of natural biologically active compounds. Chem Biodivers 2005;2:1-50.
Ghomi AS, Ali M. An efficient route to the synthesis of pyrimidine2-ones under ultrasound irradiation. Dig J Nanomater Biostruct 2010;5:303-6.
Dansena H, Dhongade HJ, Chandrakar K. Pharmacological potentials of pyrimidine derivatives: A review. Asian J Pharm Clin Res 2015;8:171-7.
Amir M, Javed SA, Kumar H. Pyrimidine as anti-inflammatory agent: A review. Indian J Pharm Sci 2007;69:337-43.
Sharma V, Chitranshi N, Agarwal AK. Significance and biological importance of pyrimidine in the microbial world. Int J Med Chem 2014;2014:202784.
Wesley F, Nadia M. Synthesis and molecular docking studies on three novel dihydropyrimidine derivatives. J Mol Struct 2019;1192:274-287.
Nongkhlaw RL, Tumtin S. Recent progress in the chemistry of dihydropyrimidinones. Rasayan J Chem 2009;3:662-76.
Shmalenyuk ER, Chernousova LN, Karpenko IL, Kochetkov SN. Inhibition of Mycobacterium tuberculosis strains H37Rv and MDR MS-115 by a new set of C5 modified pyrimidine nucleosides. Bioorg Med Chem 2013;21:487-4.
Guo D, Zhang X, Wang R, Zhou Y, Li Z, Xu J. Structural modifications of 5, 6-dihydroxypyrimidines with anti-HIV activity. Bioorg Med Chem Lett 2012;22:7114-8.
Shahu M, Siddiqie N. A review on biological importance of pyrimidines in the new era. Int J Pharm Pharm Sci 2016;5:8-21.
Brujce PY. Organic Chemistry. 3rd ed. Singapore: Pearson Education; 2007.
Sharma P, Rane N, Gurram VK. Synthesis and QSAR studies of pyrimido [4, 5-d]pyrimidine-2, 5-dione derivatives as potential antimicrobial agents. Bioorg Med Chem Lett 2004;14:4185-90.
de Clercq E. Antiviral drugs in current clinical use. J Clin Virol 2004;30:115-33.
Kapoor VK, Singh H. In: Jain MK, editor. Medicinal and Pharmaceutical Chemistry. Vol. 8. Delhi, India. Vallabh Prakashan; 2005.
Sacchi A, Laneri S, Rossi FB. The molecular structures of the isomeric compounds 5, 7-dimethoxyimidazo [1, 2-c]pyrimidine and 7-methoxy- 1-methylimidazo[1, 2-a] pyrimidine 5(1H)-one. Eur J Med Chem 1997;32:677.
Gupta JK, Chaudhary A, Dudhe R, Varuna K, Sharma PK, Verma PK. A review on the synthesis and therapeutic potential of pyrimidine derivatives. Int J Pharm Sci Res 2010;1:34-44.
Vaidya VP, Mathias P. Synthesis and pharmacological evaluation of some naptho [2, 1-b] furo [3, 2-b] pyrimidines. Indian J Heterocycl Chem 2005;14:189-92.
Chauhan M, Kumar R. Medicinal attributes of pyrazolo [3, 4-d] pyrimidines: A review. Bioorg Med Chem 2013;21:5657-68.
Sakakibara N, Hamasaki T, Baba M. Synthesis and evaluation of novel 3-(3, 5-dimethyl benzy) uracil analogues as potential anti HIV-1 agents. Bioorg Med Chem 2013;21:5900-6.
Shook BC, Chakravarty D, Barbay JK, Wang A, Leonard K, Alford V, et al. Substituted thieno [2, 3-d] pyrimidines as adenosine A2A receptor antagonists. Bioorg Med Chem Lett 2013;23:2688-91.
Kaspersen SJ, Sundby E, Charnock C, Hoff BH. Activity of 6-aryl-pyrazolo [2, 3-d] pyrimidine-4-amines to Tetrahymena. Bioorg Chem 2012;44:35-41.
Mansuri MM, Martin JC. Chapter 17. Antiviral agents. Annu Rep Med Chem 1987;22:147.
Singh P, Kumar R, Sharma BK. Quantitative structure-activity relationship study of 5-iodo-and diaryl-analogues of tubercidin: Inhibitors of adenosine kinase. J Enzyme Inhib Med Chem 2003;18:395-402.
Sondhi SM, Goyal RN, Lhoti AM, Shukla SN. Synthesis and biological evaluation of 2-thiopyrimidine derivatives. Bioorg Med Chem Lett 2005;13:3185-95.
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