• KANAAN AL-TAMEEMI Department of Microbiology, Faculty of Pharmacy, Al Andalus University for Medical Sciences, Tartous, Syria.
  • RAIAAN KABAKLI Department of Basic Sciences, Faculty of Pharmacy, Al Andalus University for Medical Sciences, Tartous, Syria.




Zika virus, Aedes genus, Transmission, Antiviral drugs, Pathogenesis


This review highlights the Zika virus which is considered a global concern due to its rapid pandemic potential and effect on humans, and according to its pandemic status, the World Health Organization declared on February 2016 it as a “Public Health Emergency of International Concern.” Therefore, we define the epidemiology of Zika virus in addition to its pathogenesis, diagnostic techniques, and treatment.


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Author Biography

KANAAN AL-TAMEEMI, Department of Microbiology, Faculty of Pharmacy, Al Andalus University for Medical Sciences, Tartous, Syria.



Available from: https://www.who.int/emergencies/zika-virus/timeline/ en.

Musso D, Gubler DJ. Zika virus. Clin Microbiol Rev 2016;29:487-524.

Cao-Lormeau VM, Roche C, Teissier A, Robin E, Berry AL, Mallet HP, et al. Zika virus, French Polynesia, South Pacific, 2013. Emerg Infect Dis 2014;20:1085-6.

Marchette NJ, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg 1969;18:411-5.

Haddow AJ, Williams MC, Woodall JP, Simpson DI, Goma LK. Twelve isolations of Zika virus from Aedes (Stegomyia) Africanus (Theobald) taken in and above a Uganda forest. Bull World Health Organ 1964;31:57-69.

Gebre Y, Forbes N, Gebre T. Zika virus infection, transmission, associated neurological disorders and birth abnormalities: A review of progress in research, priorities and knowledge gaps. Asian Pac J Trop Biomed 2016;6:815-24.

World Health Organization. Zika Epidemiology. Geneva: World Health Organization; 2019.

Sevvana M, Long F, Miller AS, Klose T, Buda G, Sun L, et al. Refinement and analysis of the mature Zika virus Cryo-EM structure at 3.1 Å resolution. Structure 2018;26:1169-77.

Cox BD, Stanton RA, Schinazi RF. Predicting Zika virus structural biology: Challenges and opportunities for intervention. Antivir Chem Chemother 2015;24:118-26.

Boigard H, Alimova A, Martin GR, Katz A, Gottlieb P, Galarza JM. Zika virus-like particle (VLP) based vaccine. PLoS Negl Trop Dis 2017;11:e0005608.

Garcia-Blanco MA, Vasudevan SG, Bradrick SS, Nicchitta C. Flavivirus RNA transactions from viral entry to genome replication. Antiviral Res 2016;134:244-9.

Li Z, Brecher M, Deng YQ, Zhang J, Sakamuru S, Liu B, et al. Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. Cell Res 2017;27:1046-64.

Christian KM, Song H, Ming GL. Pathophysiology and mechanisms of Zika virus infection in the nervous system. Annu Rev Neurosci 2019;42:249-69.

Sirohi D, Kuhn RJ. Zika virus structure, maturation, and receptors. J Infect Dis 2017;216:935-44.

Available from: https://www.commons.wikimedia.org/wiki/File:Zika_ Virus-(27023892862).jpg.

Seitz R. Zika virus (ZIKV). Transfus Med Hemother 2016;43:436-46.

Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika virus infection in human skin cells. J Virol 2015;89:8880-96.

Tappe D, Pérez-Girón JV, Zammarchi L, Rissland J, Ferreira DF, Jaenisch T, et al. Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase. Med Microbiol Immunol 2016;205:269-73.

Noorbakhsh F, Abdolmohammadi K, Fatahi Y, Dalili H, Rasoolinejad M, Rezaei F, et al. Zika virus infection, basic and clinical aspects: A review article. Iran J Public Health 2019;48:20-31.

World Health organization. Zika Virus Infection Step-by-Step Guide to Risk Communication and Community Engagement. Washington, DC: Pan American Health Organization; 2017. p. 1-37.

Miner JJ, Diamond MS. Zika virus pathogenesis and tissue tropism. Cell Host Microbe 2017;21:134-42.

Krause KK, Azouz F, Shin OS, Kumar M. Understanding the pathogenesis of Zika virus infection using animal models. Immune Netw 2017;17:287-97.

Pardy RD, Richer MJ. Zika virus pathogenesis: From early case reports to epidemics. Viruses 2019;11:886.

Baden LR. Zika virus. N Engl J Med 2016;374:1552-63.

Lowe R, Barcellos C, Brasil P, Cruz OG, Honório NA, Kuper H, et al. The Zika virus epidemic in Brazil: From discovery to future implications. Int J Environ Res Public Health 2018;15:96.

Song BH, Yun SI, Woolley M, Lee YM. Zika virus: History, epidemiology, transmission, and clinical presentation. J Neuroimmunol 2017;308:50-64.

Available from: https://www.cdc.gov/zika/healtheffects/gbs-qa. htmlpathogensis1.

Centers for Disease Control and Prevention. Key Messages-Zika Virus Disease. Atlanta, GA: Centers for Disease Control and Prevention; 2017. p. 1-47.

Hiko A, Duguma B, Muktar Y. Zika virus historical spatiotemporal distribution and potential risk factors [1900-2018]: Review. Virol Mycol 2018;7:1-9.

Available from: https://www.who.int/news-room/fact-sheets/detail/ zika-virus.

Available from: https://www.cdc.gov/zika/prevention/transmission-methods.html.

Available from: https://www.answersingenesis.org/biology/disease/ zika-virus-olympics-genesis.

Gregory CJ, Oduyebo T, Brault AC, Brooks JT, Chung KW, Hills S, et al. Modes of transmission of Zika virus. J Infect Dis 2017;216:S875-83.

Musso D, Roche C, Tu-Xuan N, Robin E, Teissier A, Cao-Lormeau VM. Detection of Zika virus in saliva. J Clin Virol 2015;68:53-5.

Gourinat AC, O’Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M. Detection of Zika virus in urine. Emerg Infect Dis 2015;21:84-6.

Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K, et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill 2014;19:20761.

Available from: https://www.cdc.gov/zika/symptoms/symptoms.html.

Barzon L, Trevisan M, Sinigaglia A, Lavezzo E, Palù G. Zika virus: From pathogenesis to disease control. FEMS Microbiol Lett 2016;363:fnw202.

Duong V, Dussart P, Buchy P. Zika virus in Asia. Int J Infect Dis 2017;54:121-8.

Tova-Herrera OE, Villanueva-Segura OK, Martínez Dávila J, Gomez- Govea MA, Medina-Sanchez A, Zamudio-Osuna M, et al. Brief description of: Zika virus. Artrópodos Salud Ene 2016;3:13-20.

Lin KW, Kraemer JD, Piltch-Loeb R, Stoto MA. The complex interpretation and management of Zika virus test results. J Am Board Fam Med 2018;31:924-30.

Shehu NY, Shwe D, Onyedibe KI, Pam VC, Abok I, Isa SE, et al. Pathogenesis, diagnostic challenges and treatment of Zika virus disease in resource-limited settings. Niger Postgrad Med J 2018;25:67-72.

Singh RK, Dhama K, Malik YS, Ramakrishnan MA, Karthik K, Tiwari R, et al. Zika virus-emergence, evolution, pathology, diagnosis, and control: Current global scenario and future perspectives-a comprehensive review. Vet Q 2016;36:150-75.

Delvecchio R, Higa LM, Pezzuto P, Valadao AL, Garcez PP, Monteiro FL, et al. Chloroquine, an endocytosis blocking agent, inhibits Zika virus infection in different cell models. Viruses 2016;8:322.

Cao B, Parnell LA, Diamond MS, Mysorekar IU. Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. J Exp Med 2017;214:2303-13.

Tong X, Smith J, Bukreyeva N, Koma T, Manning JT, Kalkeri R, et al. Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens. Antiviral Res 2017;149:34-40.

Gorshkov K, Shiryaev SA, Fertel S, Lin YW, Huang CT, Pinto. Zika virus: Origins, pathological action, and treatment strategies. Front Microbiol 2019;9:3252.

Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med 2016;22:1101-7.

Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, et al. High-content screening in hPSC-neural progenitors identifies drug candidates that inhibit Zika virus infection in fetal-like organoids and adult brain. Cell Stem Cell 2017;21:274-83.

World Health Organization. Maintaining a Safe and Adequate Blood Supply during Zika Virus Outbreaks: Interim Guidance. Geneva, Switzerland: World Health Organization; 2016.



How to Cite

AL-TAMEEMI, K., and R. KABAKLI. “ZIKA VIRUS: A BRIEF REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, vol. 13, no. 7, July 2020, pp. 21-24, doi:10.22159/ajpcr.2020.v13i7.37957.



Review Article(s)