A REVIEW ON PHARMACEUTICAL MINI TABLETS: NEW MODALITY TO ORAL DRUG DELIVERY

NAVEEN TAJ S

doi:10.22159/ajpcr.2020.v13i9.37990

Authors

NAVEEN TAJ S Department of Pharmacy, Sri Padmavati Mahila Visvavidyalayam, Women’s University, Tirupati, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i9.37990

Keywords:

Oral dosage forms, Pediatric drug delivery, Pellets

Abstract

The purpose of any selected drug delivery system (DDS) is to deliver drug to target site and to get the desired drug concentration for effective therapy. The main purpose of designing controlled or sustained DDS is to decrease the frequency of dosing and maximizing its efficiency by confining the area of action of the drug to a selected region. It is well-identified that solid oral dosage form, particularly tablets, is the most satisfactory form of delivering medication. In addition, some new variations are emerging such as mini tabs which offer more formulation flexibility. Oral controlled release DDS are classified into two categories like single unit dosage forms which include tablets, capsules, and multiple-unit dosage forms include pellets, granules, or mini tablets. Mini tablets are a new development in solid dosage forms and more beneficial and great substitute for granules and pellets. Mini tablets defined as tablets which are having diameter <3 mm and promising patient friendly drug delivery system and more acceptable in small children’s and old age people as they are easy to swallow and offer therapeutic benefits such as manufactured relatively easy, dose and formulation flexibility, combination release pattern, coating, and less solvent requirement. Dose dumping and local irritation can be avoided using mini tablets. This review highlights the various advantages of mini tablets, manufacturing processes, formulation possibilities, and their challenges.

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References

Bechgaard H, Nielsen GH. Controlled-release multiple-units and single-unit doses a literature review. Drug Dev Ind Pharm 1978;4:53-67.

Sreenivas SA, Dandagi PM, Gadad AP, Godbloe AM, Hiremath SP, Mastiholimath VS. Orodispersible tablets: New-fangled drug delivery system-a review. Indian J Pharm Educ 2005;39:177.

Siraj S, Khan GJ, Huzaifa P, Mohsin S, Sufiyan W, Afroza P, et al. Minitablet: A recent approach of drug delivery. Int J Innov Pharm Sci Res 2015;11:1609-25.

Priyanka P, Kumar K, Teotia D. A comprehensive review on pharmaceutical mini tablets. J Drug Deliv Ther 2018;8:382-90.

Ernest TB, Elder DP, Martini LG, Roberts M, Ford JL. Developing pediatric medicines: Identifying the needs and recognizing the challenges. J Pharm Pharmacol 2007;59:1043-55.

Parakh S, Oskar AG. A review of mouth dissolving tablet technologies. Pharm Technol 2003;27:92-100.

Goel H, Rai P, Rana V, Tiwary A. Orally disintegrating systems: Innovations in formulation and technology. Rec Pat Drug Deliv Form 2008;2:258-74.

Thomson SA, Tuleu C, Wong IC, Keady S, Pitt KG, Sutcliffe AG. Minitablets: New modality to deliver medicines to preschool-aged children. Pediatrics 2009;123:e235-8.

Flemming J, Mielck J. Experimental micro tableting: Construction of an instrumented punch holder for an eccentric tabletting machine. Eur J Biopharm 1996;42:212-4.

Alfred CF, David H, Francis F, Varsha B, Mary AJ. Minitablets: Manufacturing, characterization methods, and future opportunities. Am Pharm Rev 2016;19:79-82.

Dashora K, Saraf S, Saraf S. Development of sustained release multicomponent microparticulate system of diclofenac sodium and tizanidine hydrochloride. Int J Pharm Sci Nanotechnol 2008;1:98-105.

Stoltenberg I, Winzenburg G, Breitkreutz J. Solid oral dosage forms for children-formulations, excipients and acceptance issues. Eur Ind Pharm 2011;8:4-7.

Aleksovski A, Dreu R, Gasperlin M, Planinsek O. Mini-tablets: A contemporary system for oral drug delivery in targeted patient groups. Expert Opin Drug Deliv 2015;12:65-84.

Solanki B, Patel R, Barot B, Parejiya P, Shelat P. Multiple unit dosage forms: A review. Pharmtechmedica 2012;1:11-21.

Breitkreutz J, Wessel T, Boos J. Dosage forms for peroral administration to children. Paediatr Perinat Drug Ther 1999;3:25-33.

Hadi MA, Rao NG, Firangi S. Mini-tablets technology: An overview. Am J PharmTech Res 2012;2:2249-87.

Swati G, Sushma S. Multiple unit system: An approach towards gastro retention. J Biol Sci Opin 2014;2:188-95.

Joshi J, Bhakuni L, Kumar S. Formulation and evaluation of solid matrix tablets of repaglinide. Der Pharm Sin 2012;3:598-603.

Sunada H, Bi YX, Yonezawa Y, Danzo K. Preparation, evaluation and optimization of rapidly disintegrating tablets. Powder Technol 2002;122:188-98.

Ranjith K, Mahalaxmi R. Pharmaceutical mini tablets. Int J PharmTech Res 2014;7:507-15.

Mounika A, Sirisha B, Rao VU. Pharmaceutical mini tablets, its advantages and different enteric coating processes. World J Pharm Pharm Sci 2014;4:523-41.

Verma A, Gautam SP, Gautam T, Kaur S, Kanwar K. Recent advancement in tablet technology: The need of hour. Int J Pharm Drug Anal 2015;3:423-9.

Mohamed FA, Roberts M, Seton L, Ford JL, Levina M, Rajabi- Siahboomi AR. Production of extended release mini-tablets using directly compressible grades of HPMC. Drug Dev Ind Pharm 2013;39:1690-7.

Shaikh SC, Dnyaneshwar S, Bhusari DV, Jain S, Kochar PP, Sanchati VN. Formulation and evaluation of ibuprofen gastro-retentive floating tablets. Univ J Pharm Res 2018;3:20-5.

Cram A, Breitkreutz J, Desset-Brethes S, Nun T, Tuleu C. Challenges of developing palatable oral pediatric formulations. Int J Pharm 2009;365:1-3.

Kumria R, Gupta V, Bansal S, Wadhwa J, Nair AB. Oral buccoadhesive films of ondansetron: Development and evaluation. Int J Pharm Investig 2013;3:112-8.

Spomer N, Klingmann V, Stoltenberg I, Lerch C, Meissner T, Breitkreutz J. Acceptance of uncoated mini-tablets in young children: Results from a prospective exploratory cross-over study. Arch Dis Child 2012;97:283-6.

Yourong FU, Shicheng Y, Hoon JS, Susumu K, Kinam P. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. Crit Rev Ther Drug Car Sys 2004;21:433-75.

Wagh MP, Yewale CP, Zate SU, Kothawade PI, Mahale GH. Formulation and evaluation of fast dispersible tablets of aceclofenac using different superdisintegrant. Int J Pharm Sci 2010;2:154-7.

Prajapati BG, Ratnakar N. A review on recent patents on fast dissolving drug delivery system. Int J Pharm Tech Res 2009;1:790-8.

Chue P, Welch R, Binder C. Acceptability and disintegration rates of orally disintegrating risperidone tablets in patients with schizophrenia or schizoaffective disorder. Can J Psychiatry 2004;49:701-3.

Ghosh T, Ghosh A, Prasad D. A review on new generation orodispersible tablets and its future prospective. Int J Pharm Pharm Sci 2011;3:1.

Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery: A review. Pharm Sci Technol Today 2000;3:138-45.

Lopes CM, Lobo JM, Pinto JF, Costa P. Compressed mini-tablets as a biphasic delivery system. Int J Pharm 2006;323:93-100.

Lieberman HA, Schwartz JB. Compressed tablets by direct compression, and compression coated and layer tablets. In: Pharmaceutical Dosage Forms. New York: Marcel Dekker; 1989. p. 195-284.

Kirkwood C, Neill J, Breden E. Zolpidem modified-release in insomnia. Neuropsychiatr Dis Treat 2007;3:521-6.

Karthikeyan D, Vijayalaxmi A, Kumar CS. Formulation and evaluation of biphasic delivery system of aceclofenac mini-tablets in hard gelatin capsules. Int J Novel Trends Pharm Sci 2013;3:39-45.

Modi SA, Gaikwad PD, Bankar VH, Pawar SP. Sustained release drug delivery system: A review. Int J Pharm Res Dev 2011;11:147-98.

Mitra B, Chang J, Wu SJ, Wolfe CN, Ternik RL, Gunter TZ. Feasibility of mini-tablets as a flexible drug delivery tool. Int J Pharm 2017;525:149-59.

Opeyemi OT, Adegbenro OO. Development and characterization of direct compressed matrix mini tablets of naproxen sodium. Univ J Pharm Res 2018;3:7-11.

Zhu Z, Zheng L. Development and mathematical simulation of theophylline pulsatile release tablets. Drug Dev Ind Pharm 2005;31:1009-17.

Alfred CF, David H, Francis F, Varsha B, Mary AJ. Minitablets: Manufacturing, characterization methods, and future opportunities. Am Pharm Rev 2016;19:79-82.

Siddiqui MN, Garg G, Sharma PK. Fast dissolving tablets: Preparation, characterization and evaluation: An overview. Int J Pharm Sci Rev Res 2010;4:87-96.

Tawfeek HM, Saleem IY, Roberts M. Dissolution enhancement and formulation of rapid-release lornoxicam mini-tablets, pharmaceutics. Drug Deliv Pharm Technol 2014;103:2470-83.

Shivappa NN. Formulation and evaluation of furosemide oral disintegrating tablets. Int J Pharm Sci Invent 2018;7:1-10.

Reddy V, Doddayya H, Saisirisha A, Bharathi T. Development and in vitro evaluation of taste masked ondansetron HCL oral dispersible tablets by direct compression method by using different diluents. Int J Pharm Sci 2012;4:254-61.

Ishida M, Abe K, Hashizume M, Kawamura M. A novel approach to sustained pseudoephedrine release: Differentially coated mini-tablets in HPMC capsules. Int J Pharm 2008;1-2:46-52.

Mounika A, Sirisha B, Rao VU. Formulation and evaluation of fenofibric acid delayed release mini tablets in capsule. Int J Innov Pharm Sci Res 2015;3:1290-304.

Bodea M, Tomuţă I, Leucuţa S. Identification of critical formulation variables for obtaining metoprolol tartrate mini-tablets. Farmacia 2010;58:719-27.

Keerthi ML, Kiran RA, Maheshwar RV, Sannapu A, Dutt AG, Krishna KS. Pharmaceutical mini-tablets, its advantages, formulation possibilities and general evaluation aspects: A review. Int J Pharm Sci Rev Res 2014;28:214-21.

Sivakranth M, Althaf AS, Rajasekhar S. Formulation and evaluation of oral fast dissolving tablets of sildenafil citrarte. Int J Pharm Sci 2011;3:112-9.

Thakur RR, Verma A. Mouth dissolving tablets-preparation characterization and evaluation: An overview. J Pharm Res 2012;5:993- 1000.

Banker GS, Anderson NR. Tablets. In: Lachman N, Lieberman HA, Kanig JL, editors. The Theory and Practice of Industrial Pharmacy. Indian: CBS Publication House; 2009. p. 293-325.

Tehseen N, Rao V, Hadi MA. Design and characterization of twice daily mini-tablets formulation of pregabalin. Int J Pharm Pharm Sci 2013;5:168-75.

Mahajan VK, Akarte MA, Sapate KM, Baviskar TD, Jain KD. Designing and evaluation of compressed mini-tablets of ramipril as a biphasic delivery system. Indo Am J Pharm Res 2014;4:55-72.

Dey NS, Majumdar S, Rao ME. Multiparticulate drug delivery systems for controlled release. Trop J Pharm Res 2008;7:1067-75.

Biswas N, Sahoo RK, Guha A, Kuotsu K. Chronotherapeutic delivery of hydroxypropylmethylcellulose based mini-tablets: An in vitro-in vivo correlation. Int J Biol Macromol 2014;66:179-85.

United States Pharmacopoeia. National Formulary 25, Asian Edition. United States: United States Pharmacopoeia convention Inc., Rockville; 2007. p. 2647-8.

Ministry of Health and Family Welfare. Indian Pharmacopoeia, The Indian Pharmacopoeia Commission Central Indian Pharmacopoeia Laboratory Government of India. Vol. 2. Ghaziabad: Ministry of Health and Family Welfare; 2007. p. 80-4.

Bajaj S, Singla D, Sakhuja N. Stability testing of pharmaceutical products. J Appl Pharm Sci 2012;2:129-38.