A REVIEW OF THE ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF THE COMPONENTS OF THE CECROPIA GENUS

Authors

  • MAIARA ALINE DAGA Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University. https://orcid.org/0000-0001-7097-3471
  • THAÍS SOPRANI AYALA Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University. https://orcid.org/0000-0002-2080-2516
  • RAFAEL ANDRADE MENOLLI Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i8.38031

Keywords:

Urticaceae, Folk medicine, Vitexin, Orientin, Natural extracts

Abstract

The genus Cecropia belongs to the Urticaceae family and has a wide diversity of species in several regions of South America. In folk medicine, they have many uses, such as hypoglycemic, antihypertensive, anti-inflammatory, and sedative. Species of the genus Cecropia, such as Cecropia pachystachya, Cecropia glaziovii, and Cecropia obtusifolia, have been the subject of several phytochemical studies, and the main isolated compounds were orientin, isoorientin, isovitexin, vitexin, as well as c-glycosylflavonoid compounds. These active compounds were characterized as responsible for the use of Cecropia plants in the treatment of inflammation and also as antimicrobial agents. This review aims to describe the main characteristics of the genus Cecropia, exploring the compounds responsible for the medicinal uses of these species and focusing on anti-inflammatory and antimicrobial uses.

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Author Biographies

MAIARA ALINE DAGA, Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University.

Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University

THAÍS SOPRANI AYALA, Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University.

Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University

References

Müller SD, Florentino D, Ortmann CF, Martins FA, Danielski LG, Michels M, et al. Anti-inflammatory and antioxidant activities of aqueous extract of Cecropia glaziovii leaves. J Ethnopharmacol 2016;185:255-62.

Berg CC, Rosselli PF. Cecropia. New York: New York Botanical Garden Press; 2005.

da Silva Mathias M, de Oliveira RR. Differentiation of the phenolic chemical profiles of Cecropia pachystachya and Cecropia hololeuca. Phytochem Anal 2019;30:73-82.

Costa GM, Schenkel EP, Reginatto FH. Chemical and pharmacological aspects of the genus Cecropia. Nat Prod Commun 2011;6:913-20.

Pacheco NR, de Castro Campos Pinto N, da Silva JM, de Freitas Mendes R, de Carvalho da Costa J, de Oliveira Aragão DM, et al. Cecropia pachystachya : A species with expressive in vivo topical anti-inflammatory and in vitro antioxidant effects. Biomed Res Int 2014;2014:1-10.

Souza DO, Tintino SR, Figueredo FG, Borges MC, Braga MF, Felipe CF, et al. Atividade antibacteriana e moduladora de Cecropia pachystachya trécul sobre a ação de aminoglicosídeos. Rev Cuba Plantas Med 2014;19:121-32.

Lorenzi H. Brazilian Trees. 4th ed., Vol. 2. Brazil: Instituto Plantarum de Estudos da Flora; 2002.

Huxley AJ, Griffiths M, Levy M. The New RHS Dictionary of Gardening. London: MacMillan Press; 1999.

Duque AP, Pinto ND, Mendes RD, Da Silva JM, Aragão DM, Castañon MC, et al. In vivo wound healing activity of gels containing Cecropia pachystachya leaves. J Pharm Pharmacol 2016;68:128-38.

da Silva MA, Mela LV, Ribeiro RV, de Souza JP, Lima JC, de Martins DT, et al. Ethnobotanical survey of plants used as anti-hyperlipidemic and anorexigenic by the population of Nova Xavantina-MT, Brazil. Braz J Pharmacogn 2010;20:549-62.

Pilla MA, Amorozo MC, Furlan A. Acquisition, and use of medicinal plants in Martim Francisco district, Mogi Mirim municipality, São Paulo State, Brazil. Acta Bot Bras 2006;20:789-802.

De Souza CD, Felfili JM. The utilization of medicinal plants in the region of Alto Paraíso of Goiás, GO, Brazil. Acta Bot Bras 2006;20:135-42.

Gazal M, Ortmann CF, Martins FA, Streck EL, Quevedo J, de Campos AM, et al. Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress. Brain Res Bull 2014;108:10-7.

Perez RM. Anti-inflammatory activity of compounds isolated from plants. ScientificWorldJournal 2001;1:713-84.

Consolini AE, Ragone MI, Migliori GN, Conforti P, Volonté MG. Cardiotonic and sedative effects of Cecropia pachystachya Mart. (ambay) on isolated rat hearts and conscious mice. J Ethnopharmacol 2006;106:90-6.

Aragão DM, Guarize L, Lanini J, da Costa JC, Garcia RM, Scio E. Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2010;128:629-33.

Lacaille-Dubois MA, Franck U, Wagner H. Search for potential angiotensin-converting enzyme (ACE)-inhibitors from plants. Phytomedicine 2001;8:47-52.

Maquiaveli C, Da Silva ER, Francescato HD, Costa RS, Silva CG, Casarini DE, et al. Brazilian embauba (Cecropia pachystachya) extract reduces renal lesions in 5/6 nephrectomized rats. J Renin Angiotensin Aldosterone Syst 2014;15:430-9.

Lorenzi H, Matos FJ. Plantas Medicinais no Brasil: Nativas e Exóticas. 2nd ed. Nova Odessa: Instituto Plantarum de Estudos da Flora; 2008.

Petronilho F, Dal-Pizzol F, Costa GM, Kappel VD, De Oliveira SQ, Fortunato J, et al. Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract of Cecropia glaziovii (embaúba-vermelha) against acyclovir-resistant strain. Pharm Biol 2012;50:911-8.

dos Santos TC, Rescignano N, Boff L, Reginatto FH, Simões CM, de Campos AM, et al. In vitro antiherpes effect of c-glycosylflavonoid enriched fraction of Cecropia glaziovii encapsulated in PLGA nanoparticles. Mater Sci Eng C 2017;75:1214-20.

Ninahuaman MF, Souccar C, Lapa AJ, Lima-Landman MT. ACE activity during the hypotension produced by standardized aqueous extract of Cecropia glaziovii Sneth: A comparative study to captopril effects in rats. Phytomedicine 2007;14:321-7.

Lima-Landman MT, Borges AC, Cysneiros RM, De Lima TC, Souccar C, Lapa AJ. Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: An in vivo approach to the hypotensive mechanism. Phytomedicine 2007;14:314-20.

dos Santos TC, Battisti MA, Lobo KL, Caon T, Linder AE, Sonaglio D, et al. Vasorelaxant effect of standardized extract of Cecropia glaziovii Snethl encapsulated in PLGA microparticles: In vitro activity, formulation development and release studies. Mater Sci Eng C 2018;92:228-35.

Delarcina S, Lima-Landman MT, Souccar C, Cysneiros RM, Tanae MM, Lapa AJ. Inhibition of histamine-induced bronchospasm in guinea pigs treated with Cecropia glaziovii Sneth and correlation with the in vitro activity in tracheal muscles. Phytomedicine 2007;14:328-32.

Pérez-Guerrero C, Herrera MD, Ortiz R, de Sotomayor MA, Fernández MA. A pharmacological study of Cecropia obtusifolia bertol aqueous extract. J Ethnopharmacol 2001;76:279-84.

Revilla-Monsalve MC, Andrade-Cetto A, Palomino-Garibay MA, Wiedenfeld H, Islas-Andrade S. Hypoglycemic effect of Cecropia obtusifolia bertol aqueous extracts on Type 2 diabetic patients. J Ethnopharmacol 2007;111:636-40.

Nicasio P, Aguilar-Santamaría L, Aranda E, Ortiz S, González M. Hypoglycemic effect and chlorogenic acid content in two Cecropia species. Phyther Res 2005;19:661-4.

Vidrio H, Garcia-Màrquez F, Reyes J, Soto RM. Hypotensive activity of Cecropia obtusifolia. J Pharm Sci 1982;71:475-6.

Salas I, Brenes JR, Morales OM. Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats. Rev Biol Trop 1987;35:127-30.

Cano JH, Volpato G. Herbal mixtures in the traditional medicine of Eastern Cuba. J Ethnopharmacol 2004;90:293-316.

Li J, Coleman CM, Wu H, Burandt CL, Ferreira D, Zjawiony JK. Triterpenoids and flavonoids from Cecropia schreberiana Miq. (Urticaceae). Biochem Syst Ecol 2013;48:96-9.

Ortmann CF, Abelaira HM, Réus GZ, Ignácio ZM, Chaves VC, dos Santos TC, et al. LC/QTOF profile and preliminary stability studies of an enriched flavonoid fraction of Cecropia pachystachya trécul leaves with potential antidepressant-like activity. Biomed Chromatogr 2017;31:1-13.

Uchôa VT, De Paula RC, Krettli LG, Santana AE, Krettli AU. Antimalarial activity of compounds and mixed fractions of Cecropia pachystachya. Drug Dev Res 2010;71:82-91.

Strada CL, da C Lima K, da Silva VC, Ribeiro RV, de C Dores EF, Dall’Oglio EL, et al. Isovitexin as a marker and bioactive compound in the antinociceptive activity of the Brazilian crude drug extracts of Echinodorus scaber and E. grandiflorus. Braz J Pharmacogn 2017;27:619-26.

Özkay ÜD, Can ÖD. Anti-nociceptive effect of vitexin mediated by the opioid system in mice. Pharmacol Biochem Behav 2013;109:23-30.

Rosa SI, Rios-Santos F, Balogun SO, Martins DT. Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2, and JNK pathway. Phytomedicine 2016;23:9-17.

Borghi SM, Carvalho TT, Staurengo-Ferrari L, Hohmann MS, Pinge- Filho P, Casagrande R, et al. Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress and cytokines. J Nat Prod 2013;76:1141-9.

Lin CM, Huang ST, Liang YC, Lin MS, Shih CM, Chang YC, et al. Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. Planta Med 2005;71:748-53.

Huang ST, Chen CT, Chieng KT, Huang SH, Chiang BH, Wang LF, et al. Inhibitory effects of a rice hull constituent on tumor necrosis factor α, prostaglandin E2, and cyclooxygenase-2 production in lipopolysaccharide-activated mouse macrophages. Ann N Y Acad Sci 2005;1042:387-95.

Ye T, Su J, Huang C, Yu D, Dai S, Huang X, et al. Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. Onco Targets Ther 2016;9:7481-92.

Sun Y, Tao C, Huang X, He H, Shi H, Zhang Q, et al. Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway. Onco Targets Ther 2016;9:2845-53.

Wu WD, Hu ZM, Shang MJ, Zhao DJ, Zhang CW, Hong DF, et al. Cordycepin down-regulates multiple drug-resistant (MDR)/HIF-1α through regulating AMPK/mTORC1 signaling in GBC-SD gallbladder cancer cells. Int J Mol Sci 2014;15:12778-90.

Yuan L, Wang J, Xiao H, Wu W, Wang Y, Liu X. MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells. Food Chem Toxicol 2013;53:62-8.

Wedler J, Daubitz T, Schlotterbeck G, Butterweck V. In vitro anti-inflammatory and wound-healing potential of a Phyllostachys edulis leaf extract-identification of isoorientin as an active compound. Planta Med 2014;80:1678-84.

Küpeli E, Aslan M, Gürbüz İ, Yesilada E. Evaluation of in vivo biological activity profile of isoorientin. Zeitschrift für Naturforsch C 2004;59:787-90.

Thangaraj K, Vaiyapuri M. Orientin, a c-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis. Biomed Pharmacother 2017;96:1253-66.

Xiao Q, Qu Z, Zhao Y, Yang L, Gao P. Orientin ameliorates LPS-induced inflammatory responses through the inhibitory of the NF-κB pathway and NLRP3 inflammasome. Evid Based Complement Altern Med 2017;2017:1-8.

Brango-Vanegas J, Costa GM, Ortmann CF, Schenkel EP, Reginatto FH, Ramos FA, et al. Glycosylflavonoids from Cecropia pachystachya Trécul are quorum sensing inhibitors. Phytomedicine 2014;21:670-5.

da Silva FA, de Farias Freire SM, da Rocha Borges MO, Barros FE, da de Sousa M, de Sousa Ribeiro MN, et al. Antinociceptive and anti-inflammatory effects of triterpenes from Pluchea quitoc DC aerial parts. Pharmacogn Res 2017;9 Suppl 1:S1-4.

Garcia AR, Amaral AC, Azevedo MM, Corte-Real S, Lopes RC, Alviano CS, et al. Cytotoxicity and anti-Leishmania amazonensis activity of Citrus sinensis leaf extracts. Pharm Biol 2017;55:1780-6.

Odonne G, Berger F, Stien D, Grenand P, Bourdy G. Treatment of leishmaniasis in the Oyapock basin (French Guiana): A K.A.P. Survey and analysis of the evolution of phytotherapy knowledge amongst Wayãpi Indians. J Ethnopharmacol 2011;137:1228-39.

Maquiaveli CC, Da Silva ER, Rosa LC, Francescato HD, Lucon JF Jr., Silva CG, et al. Cecropia pachystachya extract attenuated the renal lesion in 5/6 nephrectomized rats by reducing inflammation and renal arginase activity. J Ethnopharmacol 2014;158:49-57.

de Oliveira Aragão DM, de Assis Lima IV, da Silva JM, Bellozi PM, de Carvalho da Costa J, Cardoso GM, et al. Anti-inflammatory, antinociceptive and cytotoxic effects of the methanol extract of Cecropia pachystachya Trecul. Phytother Res 2013;27:926-30.

Schinella G, Aquila S, Dade M, Giner R, Recio MD, Spegazzini E, et al. Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya. Planta Med 2008;74:215-20.

Nayak BS. Cecropia peltata L (Cecropiaceae) has wound-healing potential: A preclinical study in a Sprague Dawley rat model. Int J Low Extrem Wounds 2006;5:20-6.

Machado EG, Cardoso O, Lima NM, Carvalho PE, Barbosa AD, Sobrinho GF, et al. Cecropia hololeuca : A new source of compounds with potential anti-inflammatory action. Nat Prod Res 2019;2019:1-6.

Fürstenberger G, Csuk-Glänzer BI, Marks F, Keppler D. Phorbol ester-induced leukotriene biosynthesis and tumor promotion in mouse epidermis. Carcinogenesis 1994;15:2823-7.

Chang TN, Huang SS, Chang YS, Chang CI, Yang HL, Deng JS, et al. Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice. J Agric Food Chem 2011;59:9112-9.

Hong J, Smith TJ, Ho CT, August DA, Yang CS. Effects of purified green and black tea polyphenols on cyclooxygenase-and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem Pharmacol 2001;62:1175-83.

Dudhgaonkar SP, Tandan SK, Bhat AS, Jadhav SH, Kumar D. Synergistic anti-inflammatory interaction between meloxicam and aminoguanidine hydrochloride in carrageenan-induced acute inflammation in rats. Life Sci 2006;78:1044-8.

Kirkova M, Kassabova T, Russanov E. In vivo effects of indomethacin-I. Activity of antioxidant enzymes and lipid peroxidation. Gen Pharmacol Vasc Syst 1992;23:503-7.

Formagio-Neto F, Volobuff CR, Pederiva MM, Pereira ZV, Sarragiotto MH, Cardoso CA, et al. Anti-inflammatory action of an alkaloid fraction and extract from Alchornea glandulosa in mice. J Ethnopharmacol 2019;231:66-72.

Da Silva JV, dos Santos RC, Júnior PC, Pederiva MM, do Carmo Vieira M, Kassuya CA, et al. Anti-inflammatory, antioxidant and antiproliferative activities from Trichilia silvatica (C.DC). Curr Pharm Biotechnol 2019;19:973-81.

Fortis-Barrera ML, Alarcón-Aguilar FJ, Becerril-García A, Flores-Sáenz JL, Almanza-Pérez JC, García-Lorenzana M, et al. Mechanism of the hypoglycemic activity and hepatoprotective effect of the aqueous extract of Cecropia obtusifolia Bertol. J Med Food 2020;23:783-92.

Rojas JJ, Ochoa VJ, Ocampo SA, Muñoz JF. Screening for antimicrobial activity of ten medicinal plants used in Colombian folkloric medicine: A possible alternative in the treatment of non-nosocomial infections. BMC Complement Altern Med 2006;6:1-6.

Cáceres A, Menéndez H, Méndez E, Cohobón E, Samayoa BE, Jauregui E, et al. Antigonorrhoeal activity of plants used in Guatemala for the treatment of sexually transmitted diseases. J Ethnopharmacol 1995;48:85-8.

Silva IT, Costa GM, Stoco PH, Schenkel EP, Reginatto FH, Simões CM. In vitro antiherpes effects of a c-glycosylflavonoid-enriched fraction of Cecropia glaziovii Sneth. Lett Appl Microbiol 2010;51:143-8.

Okuda T. Systematics and health effects of chemically distinct tannins in medicinal plants. Phytochemistry 2005;66:2012-31.

Orhan DD, Özçelik B, Özgen S, Ergun F. Antibacterial, antifungal, and antiviral activities of some flavonoids. Microbiol Res 2010;165:496-504.

Cruz ED, Da Silva ER, Maquiaveli CD, Alves ES, Lucon JF, Dos Reis MB, et al. Leishmanicidal activity of Cecropia pachystachya flavonoids: Arginase inhibition and altered mitochondrial DNA arrangement. Phytochemistry 2013;89:71-7.

Ribeiro TG, Chávez-Fumagalli MA, Valadares DG, Franca JR, Lage PS, Duarte MC, et al. Antileishmanial activity and cytotoxicity of Brazilian plants. Exp Parasitol 2014;143:60-8.

Carvajal JE, Caicedo PE, Jiménez VO, Cárdenas GG. Antiplasmodial and haemolytic activity of ethanolic extracts and fractions obtained from Cecropia membranacea Trécul. and Cecropia metensis Cuatrec. (syn. Cecropia peltata var. candida Velásquez). Rev Cubana Med Trop 2014;66:58-70.

Freitas da CJ, Hoscheid J. Phychochemical profile, and evaluation of antimicrobial activity of aqueous and ethanolic extracts of Cecropia pachystachya leaves. Rev Fitos 2018;12:175-85.

Sabbagh G, Berakdar N. Molecular docking study of flavonoid compounds as inhibitors of β-ketoacyl acyl carrier proteins synthase II (KAS II) of Pseudomonas aeruginosa. Int J Pharm Pharm Sci 2016;8:52-61.

Published

07-08-2020

How to Cite

DAGA, M. A., T. S. AYALA, and R. A. MENOLLI. “A REVIEW OF THE ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF THE COMPONENTS OF THE CECROPIA GENUS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 13, no. 8, Aug. 2020, pp. 13-20, doi:10.22159/ajpcr.2020.v13i8.38031.

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Section

Review Article(s)