HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF ROSTELLULARIA PROCUMBENS BY USING ETHANOL INDUCED MODEL IN RATS
Abstract
The present study was carried out to evaluate the hepatoprotective activity of leaves of Rostellularia procumbens (Acanthaceae) .The plant extract was prepared and examined against ethanol induced liver damage in wistar rats using silymarin as standard. The extract was screened for alkaloids, steroids, proteins, flavanoides, saponins, carbohydrates, tannins and glycosides. Enzyme activities of Serum glutamate oxaloacetate (SGOT), Serum glutamate pyruvate transaminase (SGPT), Alkaline phosphatase, Total bilirubin and Total protein levels are analysed. Results indicate that the methanolic leaf extract had protective activity over ethanol induced hepatotoxicity when compared with toxic control and silymarin groups. Results of present investigation confirm the hepatoprotective activity of MERP at 250mg/kg and 500mg/kg doses. The statistical analysis was carried out using one way analysis of varience (ANOVA) followed by Dunnet's t-test. P –values <0.05 were considered as significant.
Key words: Rostellularia procumbens , SGOT, SGPT, TB, TP,ALP, ethanolDownloads
References
Shu YZ. Recent natural products based drug development: A pharmaceutical industry perspective. J Nat Prod 1998;61:1053-71.
Pandey M, Debnath M, Gupta S, Chikara SK. Phytomedicine an ancient approach turning into future potential source of therapeutics. J Pharmacogn Phytother 2011;3(3):27-37.
Ravishankar B, Shukla VJ. Indian systems of medicine: A brief profile. Afr J Tradit Complement Altern Med 2007;4(3):319-37.
Kaido TL, Veale DJ, Havlik I, Rama DB. Preliminary screening of plants used in South Africa as traditional herbal remedies during pregnancy and labour. J Ethnopharmacol 1997;55(3):185-91.
Ward FM, Daly MJ. Liver disease. In: Walker R, Edwards C, editors. Clinical Pharmacy and Therapeutics. 3rd ed. New York: Churchill Livingstone; 2005. p. 209.
Rajan BG, Chezhiyan N. Strength and wealth of therapeutic medicinal plants in India. In: Khan IA, Khanum A, editors. Role of Biotechnology in Medicinal and Aromatic Plants, Special Volume on Diseases. Vol. 6. Hyderabad: Ukaaz Publications; 2002. p. 151-2.
Mossa JS, Tariq M, Mohsin A, Ageel AM, al-Yahya MA, al-Said MS, et al. Pharmacological studies on aerial parts of Calotropis procera. Am J Chin Med 1991;19(3-4):223-31.
Mascolo N, Sharma R, Jain SC, Capasso F. Ethnopharmacology of Calotropis procera flowers. J Ethnopharmacol 1988;22(2):211-21.
Balne D, Pallerla P, Vanapatla SR, Bobbala RK. Hepatoprotective effect of whole plant extract fractions of Marsilea minuta linn. Asian J Pharm Clin Res 2013;6(3):100-7.
Kshirsagar AD, Mohiter R, Aggarwal AS, Suralkar UR. Hepaoprotactive medicinal plants of ayuveda. Asian J Pharm Clin Res 2013;4(3):1-8.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.