GLIMPSE STUDY: IMPACT OF TRIPLE THERAPY ON LUNG FUNCTION, HEALTH STATUS, AND MORTALITY RISK IN PATIENTS WITH ADVANCED CHRONIC OBSTRUCTIVE PULMONARY DISEASE

SALVA FATIMA HEBA; SYED AAMIR ALI; MOHAMMED ALEEMUDDIN NAVEED; SALWA MEHRIN; MAARIA GULNAAZ; NAUSHEEN FATIMA

doi:10.22159/ajpcr.2021.v14i1.39505

Authors

SALVA FATIMA HEBA Department of Pharmacy Practice, Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad, Telangana, India.
SYED AAMIR ALI Department of Pharmacy Practice, Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad, Telangana, India.
MOHAMMED ALEEMUDDIN NAVEED Department of Respiratory Medicine, Deccan College of Medical Sciences, DMRL “X” Road, Kanchanbagh, Hyderabad, Telangana, India.
SALWA MEHRIN Department of Pharmacy Practice, Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad, Telangana, India.
MAARIA GULNAAZ Department of Pharmacy Practice, Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad, Telangana, India.
NAUSHEEN FATIMA Department of Pharmacy Practice, Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad, Telangana, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i1.39505

Keywords:

Chronic obstructive pulmonary disease, Triple therapy, Lung function, Health status, Mortality risk

Abstract

Objectives: The objectives of the study were to estimate the relative impact of triple therapy on lung function, health status, and mortality risk compared with combination inhaled corticosteroid (ICS)/long-acting β-agonist (LABA) therapy in symptomatic chronic obstructive pulmonary disease (COPD) patients with frequent exacerbations in an Indian clinical population.

Methodology: The GLIMPSE (Lung Function, Health Status, and Mortality Risk Assessment in COPD using Triple Therapy) was as a prospective, parallel design, single-center observational study comparing 24 weeks of triple therapy (twice-daily combination of budesonide [BUD]-formoterol [FOR] [100/6 μg] and once-daily tiotropium [TIO] [9 μg]) with ICS/LABA (twice daily BUD-FOR [100/6 μg]). The primary outcome was the mean change in forced expiratory volume in the 1st s (FEV1%) predicted and COPD assessment test total score from baseline at week 24. Secondary outcomes were variation in dyspnea grade and BODE total score from baseline.

Results: At week 24 in triple therapy (n=70) and ICS/LABA therapy (n=70), mean difference from baseline in FEV1% predicted were 5.40 (95% confidence interval [CI]: 1.29–9.50) and 1.90 (95% CI: –1.87–5.68) respectively, and mean difference in CAT total score from baseline was –5.10 units (95% CI: –3.49–−6.71) and –1.80 units (95% CI: –0.052–−3.548), respectively. In addition, there was a statistically significant reduction in dyspnea grading and BODE score with comparable adverse events in both groups.

Conclusion: Overall, the results favored triple therapy over dual therapy in advanced symptomatic COPD patients.

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