CASE STUDY: ORGANOPHOSPHATE POISONING – ATROPINE-INDUCED PSYCHOSIS IN INTENSIVE CARE UNIT PATIENT

VATHSALYA PORANKI

doi:10.22159/ajpcr.2021.v14i1.39921

Authors

VATHSALYA PORANKI Department of Pharmacy Practice, A.M Reddy Memorial College of Pharmacy Narasaraopet, Guntur, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i1.39921

Keywords:

Organophosphate, Poisoning, Atropine, Psychosis, Antidote, Patient

Abstract

Organophosphate compounds are used as commercial insecticides and applied as aerosols or dust. Consuming these compounds intentionally or unintentionally lead to dangerous conditions even to fatality. The most common obstacle in treating organophosphorus poisoning is the availability of sufficient medical care, equipment to provide proper emergency care observed in rural areas where there is a lot of gap between intensive care and acute care. Atropine use is as an antidote in organophosphorus poisoning. The dose of atropine mainly depends on the organophosphorus toxic doses. Atropine is a competitive antagonist of acetylcholine at the muscarinic postsynaptic membrane. Atropine blocks all the muscarinic effects in the body. This study presents a case of organophosphorus poisoning treated with atropine leading to atropine psychosis. Patient’s conditions, outcomes, and improvements are studied.

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References

Pandit V, Seshadri S, Rao SN, Samarasinghe C, Kumar A, Valsalan R. A case of organophosphate poisoning presenting with seizure and unavailable history of parenteral suicide attempt. J Emerg Trauma Shock 2011;4:132-4.

Eddleston M, Buckley NA, Eyer P, Dawson AH. Management of acute organophosphorus pesticide poisoning. Lancet 2008;371: 597-607.

Bhattarai MD, Singh DL, Chalise BS, Koirala P. A case report and overview of organophosphate (OP) poisoning. Kathmandu Univ Med J 2006;4:100-4.

Johnson MK, Jacobsen D, Meredith TJ, Eyer P, Heath AJ, Ligtenstein DA, et al. Evaluation of antidotes for poisoning by organophosphorus pesticides. Emerg Med Aust 2000;12:22-37.

O’Malley GF, O’Malley R. Organophosphate Poisoning and Carbamate Poisoning. MSD Manuals. Kenilworth, NJ: Merck Sharp and Dohme Corporation.