ASSOCIATION BETWEEN ELEVATED HIGH SENSITIVITY CARDIAC-TROPONIN I LEVELS AND INCREASE IN LEVELS OF C-REACTIVE PROTEIN, INTERLEUKIN-6, D-DIMER, AND CONSEQUENT CARDIAC INJURY AND MORTALITY FOR PATIENTS WITH CORONAVIRUS DISEASE 2019: A META-ANALYSIS

DHEAA SHAMIKH ZAGEER; SUNDUS FADHIL HANTOOSH; WATHIQ Q SH. ALI

doi:10.22159/ajpcr.2021.v14i6.41491

Authors

DHEAA SHAMIKH ZAGEER Forensic DNA Center for Research and Training, AL-Nahrain University, Baghdad, Iraq.
SUNDUS FADHIL HANTOOSH Department of Training and Development, Forensic DNA Center for Research and Training, AL-Nahrain University, Baghdad, Iraq.
WATHIQ Q SH. ALI Department of Applied Embryology, High Institute of Infertility Diagnosis and ART, AL-Nahrain University, Baghdad, Iraq.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i6.41491

Keywords:

High sensitivity-cardiac troponin I, Cardiac injury, C-reactive protein, Interleukin-6, D-dimer, Death

Abstract

Objectives: This meta-analysis aims to investigate the role of high sensitivity-cardiac troponin I (hs-cTnI) as a prognostic factor for cardiac injury and as a risk factor of death for patients with coronavirus disease 2019 (COVID-19). This meta-analysis studies the impact of hs-cTnI elevated levels on C-reactive protein (C-RP) protein, interleukin-6 (IL-6), and D-dimer (DD) levels in COVID-19 affected individuals.

Methods: Of 557 downloaded articles according to chosen criteria for this meta-analysis, 11 were finally chosen as they met the criteria.

Results: Male and elderly individuals were noticeably prone to COVID-19 infection and considerably underwent death in comparison with female and young individuals. Levels of hs-cTn I, C-RP, IL-6, and DD were significantly higher among dead compare to survivors for COVID-19 affected individuals.

Conclusions: Levels of C-RP, IL-6, and DD were considerably high and in linear relation with elevated hs-cTn I levels. Hs-cTn I can be considered a reliable marker for COVID-19 infection prognosis and potent predictor of decease.

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