HEPARAN SULFATE: LANDING SITE FOR THE DENGUE VIRAL STRAINS TO GAIN ENTRY TO THE HOST CELLS

ABDUL GHAYUM PAPULZAI; NIKHIYA MANUEL JOHN; SUDHAKAR MALLA

doi:10.22159/ajpcr.2021.v14i11.42536

Authors

ABDUL GHAYUM PAPULZAI Department of Biotechnology, St. George College of Management and Science, Bengaluru, Karnataka, India.
NIKHIYA MANUEL JOHN Department of Biotechnology, St. George College of Management and Science, Bengaluru, Karnataka, India.
SUDHAKAR MALLA Department of Biotechnology, Indian Academy Degree College-Autonomous, Bengaluru, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i11.42536

Keywords:

DENV, Envelope protein, Heparan sulfate, Conserved domains

Abstract

Humans usually contract dengue by being bitten by arthropods, and more than 3.6 billion people are at risk per year. Although studies are conducted to screen and trace out the possible pathophysiology of the virus, an adequate receptor-based study has not been completed. Understanding how the dengue virus (DV) engraves its landing sites requires identification of such cellular receptors. In many model studies, heparan sulfate (HS) has been reported to act as a DV receptor under various conditions. However, the physiological relevance of these findings remains uncertain. Therefore, it is still unclear whether HS is used by viral strains or not, and if at all used by clinical or non-cell culture-adapted strains of DV. The present review aims to identify relevant experimental evidences that confirm the possible interaction between envelope protein and HS chains. We collected data from a series of studies to conclude the interactive role.

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