RELATIONSHIP BETWEEN SERUM LEVELS OF IMMUNOGLOBULIN M-ANTI PHENOLIC GLYCOLIPID 1 AND IMMUNOGLOBULIN G-ANTI PHENOLIC GLYCOLIPID 1 WITH BACTERIA INDEX VALUES IN MULTIBACILLARY LEPROSY

FITRIYANTI FITRIYANTI

doi:10.22159/ajpcr.2021.v14i10.42565

Authors

FITRIYANTI FITRIYANTI Department of Skin and Venereology Raden Mattaher Hospital/Faculty of Medicine, University of Jambi, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i10.42565

Keywords:

Immunoglobulin M-anti-phenolic glycolipid 1, Immunoglobulin G-anti-phenolic glycolipid, Bacterial index, Slit skin smear

Abstract

Objective: This study aims to determine the relationship of serum levels of anti-phenolic glycolipid (PGL-1), immunoglobulin M (IgM), and anti-PGL-1 immunoglobulin G (IgG) with bacterial index (BI) values in multibacillary (MB) leprosy.

Methods: This study was an observational study with a cross-sectional design. A total of 30 study samples were examined for a Slit Skin Smear and examined serum levels of IgM and IgG Anti PGL-1 antibodies by ELISA method.

Results: The results showed the higher the BI value, the serum levels of IgM anti-PGL-1 and IgG anti-PGL-1 increased.

Conclusion: There was a significant relationship between IgM anti-PGL-1 with BI value in MB leprosy (p<0.05), but there was no significant relationship between IgG anti-PGL-1 with BI value in MB leprosy (p>0.05). IgM anti-PGL-1 has more role in increasing the value of BI in MB leprosy.

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