EFFICACY OF TERIPARATIDE IN COMMINUTED FRACTURE HEALING IN LOWER LIMB: A RETROSPECTIVE STUDY

Authors

  • SNEH DUDHIA Department of Pharmacology, Parul Institute of Medical Sciences and Research, Vadodara, Gujarat, India.
  • KETAS MAHAJAN Department of Orthopaedics, Parul Sevashram Hospital, Vadodara, Gujarat, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i11.43135

Keywords:

Teriparatide, Comminuted, Fracture healing

Abstract

Objective: The objective of the study was to show the efficacy of teriparatide in comminuted fracture healing and improvement in overall functional recovery.

Methods: A total of 30 subjects who suffered from comminuted fractures of lower limb were selected. Subjects were categorized into two groups: Group A (n=15) contained individuals with teriparatide administration and Group B (n=15) contained individuals who were not administered teriparatide. 20 mg of teriparatide was injected subcutaneously for a period of 3 months. Patients were followed up ay durations of 4, 8, and 12 weeks. Obtained data were entered into Microsoft Excel Worksheets and descriptive analysis was performed. Chi-square test was used to analyze all obtained data.

Results: Among Group A patients, the fracture healing rates were found to be significantly earlier with comparison to control group (Group B).

Conclusion: Teriparatide was observed to be effective in comminuted fracture healing and has demonstrated good clinical outcome.

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References

Kundu S. Role of teriparatide in delayed union and non-union of fractures. Int J Clin Case Stud Rep 2020;2:100-10.

Lou S, Lv H, Li Z, Tang P, Wang Y. Parathyroid hormone analogues for fracture healing: Protocol for a systematic review and meta-analysis of randomised controlled trials. BMJ Open 2018;8:e019291.

Raghavan P, Christofides E. Role of teriparatide in accelerating metatarsal stress fracture healing: A case series and review of literature. Clin Med Insights Endocrinol Diabetes 2012;5:39-45.

Kim Y, Tanaka C, Tada H, Kanoe H, Shirai T. Radiographic features of teriparatide-induced healing of femoral fractures. Bone Rep 2015;3:11-4.

Yang YS, Tsou YS, Lo WC, Chiang YH, Lin JH. Teriparatide associated with fewer refractures and higher body heights of cemented vertebrae after vertebroplasty: A matched cohort study. Sci Rep 2020;10:6005.

Hong H, Song T, Liu Y, Li J, Jiang Q, Song Q, et al. The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis. Clinics (Sao Paulo) 2019;74:e800.

Kaback LA, Soung DY, Naik A, Geneau G, Schwarz EM, Rosier RN, O’Keefe RJ, et al. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem 2008;105:219-26.

Babu S, Sandiford NA, Vrahas M. Use of teriparatide to improve fracture healing: What is the evidence? World J Orthop 2015;6:457-61.

Mishra JK, Mohapatra NC, Kar BK. Effect of daily teriperatide for delayed union of fracture neck of the femur. J OrthopTraumatol Rehabi 2019;11:49-52.

Kim SJ, Park HS, Lee DW, Lee JW. Short-term daily teriparatide improve postoperative functional outcome and fracture healing in unstable intertrochanteric fractures. Injury 2019;50:1364-70.

Yukata K, Kanchiku T, Egawa H, Nakamura M, Nishida N, Hashimoto T, et al. Continuous infusion of PTH1-34 delayed fracture healing in mice. Sci Rep 2018;8:13175.

Saraf HR, Munot S. Role of teriperatide in fracture healing: A prospective study. Int J Othop Sci 2017;3:445-52.

Hodsman AB, Baner DC, Dempster DW, Dian L, Hanley DA, Harris ST, et al. Parathyroid hormone and teriparatide for the treatment of osteoporosis: A review of the evidenc and suggested guidelines for its use. Endocr Rev 2005;26:688-703.

Bovbjerg P, Høgh D, Froberg L, Schmal H, Kassem M. Effect of PTH treatment on bone healing in insufficiency fractures of the pelvis: A systematic review. EFORT Open Rev 2021;6:9-14.

Borges JL, Freitas A, Bilezikian JP. Accelerated fracture healing with teriparatide. Arq Bras Endocrinol Metabol 2013;57:153-6.

Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, et al. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 2009;24:1651-61.

Bhandari M, Jin L, See K, Burge R, Gilchrist N, Witvrouw R, et al. Does teriparatide improve femoral neck fracture healing: Results from a randomized placebo-controlled trial. Clin Orthop Relat Res 2016;474:1234-44.

Lou S, Lv H, Wang G, Zhang L, Li M, Li Z, et al. The effect of teriparatide on fracture healing of osteoporotic patients: A meta-analysis of randomized controlled trials. BioMed Res Int 2016;2016:1-10.

Yoon BH, Kim KC. Does teriparatide improve fracture union?: A systematic review. J Bone Metab 2020;27:167-74.

Chiang CY, Zebaze RM, Ghasem-Zadeh A, Iuliano-Burns S, Hardidge A, Seeman E. Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. Bone 2013;52:360-5.

Gomberg SJ, Wustrack RL, Napoli N, Arnaud CD, Black DM. Teriparatide, Vitamin D, and calcium healed bilateral subtrochanteric stress fractures in a postmenopausal woman with a 13-year history of continuous alendronate therapy. J Clin Endocrinol Metab 2011;96:1627-32.

Published

07-11-2021

How to Cite

DUDHIA, S., and K. MAHAJAN. “EFFICACY OF TERIPARATIDE IN COMMINUTED FRACTURE HEALING IN LOWER LIMB: A RETROSPECTIVE STUDY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 14, no. 11, Nov. 2021, pp. 57-59, doi:10.22159/ajpcr.2021.v14i11.43135.

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