A REVIEW ON MULTIPURPOSE MEDICINAL PROPERTIES OF TRADITIONALLY USED PSIDIUM GUAJAVA LEAVES
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i8.43179Keywords:
Phytoconstituents, Pharmacological and structural use, Psidium guajava, Traditional useAbstract
Psidium guajava is an important food crop and medicinal plant available in tropical and subtropical countries. P. guajava (Guava), belonging to the family of Myrtaceae. P. guajava Linn. (Guava) is used not only as food but also as folk medicine in subtropical areas around the world because of its pharmacologic activities. It contains important phytoconstituents such as tannins, triterpenes, flavonoid, quercetin, pentacyclic triterpenoid, guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, beta-sitosterol, uvaol, oleanolic acid, and ursolic acid. Conventionally, guava is used for the treatment of various ailments such as antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, cardioactive, anti-cough, antidiabetic, anti-inflammatory, and antinociceptive activities, supporting its traditional uses.
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Leonti M, Vibrans H, Sticher O, Heinrich M. Ethnopharmacology of the Popoluca, Mexico: An evaluation. J Pharm Pharmacol 2001;53:1653- 69. doi: 10.1211/0022357011778052, PMID 11804396
Martínez-Moreno D, Alvarado-Flores R, Mendoza-Cruz M, Basurto- Peña F. Plantas Medicinales de cuatro mercados del Estado de Puebla, México. Soc Botánica México Bot Sci 2006;79:79-87. doi: 10.17129/ botsci.1735
Peral Pacheco D, Martín Alvarado MÁ, Villalobos V, Roset JR, Roura Poch P. La medicina popular en la ciudad de Badajoz. Rev Estud Extrem 2009;LXV:1389-438.
Oh WK, Lee CH, Lee MS, Bae EY, Sohn CB, Oh H, et al. Antidiabetic effects of extracts from Psidium guajava. J Ethnopharmacol 2005;96:411-5. doi: 10.1016/j.jep.2004.09.041, PMID 15619559
Ojewole JA. Hypoglycaemic and hypotensive effects of Psidium gajava Linn. (Myrtaceae) leaf aqueous extract. Methods Find Exp Clin Pharmacol 2005;27:689. doi: 10.1358/mf.2005.27.10.948917
Fresquet J, Blanquer G, Galindo M, Gallego F, García de la Cuadra R, López J, et al. Inventario de las plantas medicinales de uso popular en la ciudad de Valencia. Med Cienc Soc 2001;13:1-24.
de Oliveira Teixeira R, Camparoto ML, Mantovani MS, Pimenta Vicentini VE. Assessment of two medicinal plants, Psidium guajava L. and Achillea millefolium L., in vitro and in vivo assays. Genet Mol Biol 2003;26:551-5.
Louppe G. Understanding Random Forests. Ithaca, New York: Cornell University Library 2014. p. 1-225.
Aparicio Mena AJ. La medicina tradicional como medicina ecocultural. Gaz Antropol 2005;21:1-9. doi: 10.30827/Digibug.7181
Tona L, Kambu K, Mesia K, Cimanga K, Apers S, De Bruyne T, et al. Biological screening of traditional preparations from some medicinal plants used as antidiarrhoeal in Kinshasa, Congo. Phytomedicine 1999;6:59-66. doi: 10.1016/S0944-7113(99)80036- 1, PMID 10228613
WHO. WHO monographs on selected medicinal plants. World Health 1999;1:390.
Sato J, Goto K, Nanjo F, Kawai S, Murata K. Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola. J Biosci Bioeng 2000;90:442-6. doi: 10.1016/S1389-1723(01)80016-5,PMID 16232887
Mayet N, Choonara YE, Kumar P, Tomar LK, Tyagi C, Du Toit LC, et al. A comprehensive review of advanced biopolymeric wound healing systems. J Pharm Sci 2014;103:2211-30. doi: 10.1002/ jps.24068, PMID 24985412
Holetz FB, Pessini GL, Sanches NR, Cortez DA, Nakamura CV, Filho BP. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 2002;97:1027-31. doi: 10.1590/s0074-02762002000700017, PMID 12471432
Almeida CE, Karnikowski MG, Foleto R, Baldisserotto B. Analysis of antidiarrhoeic effect of plants used in popular medicine. Rev Saude Publica 1995;29:428-33. doi: 10.1590/s0034-89101995000600002, PMID 8734966
Joseph B, Priya RM, Helen PA, Sujatha S. Bio-active compounds in essential oil and its effects of antimicrobial, cytotoxic activity from the Psidium guajava (L.) leaf. J Adv Biotechnol 2010;9:10-4.
Begum S, Hassan SI, Ali SN, Siddiqui BS. Chemical constituents from the leaves of Psidium guajava. Nat Prod Res 2004;18:135-40. doi: 10.1080/14786410310001608019, PMID 14984086
Latza S, Ganßer D, Berger RG. Carbohydrate esters of cinnamic acid from fruits of Physalis peruviana, Psidium guajava and Vaccinium vitis-idaea. Phytochemistry 1996;43:481-5. doi: 10.1016/0031- 9422(96)00303-2
Jiménez-Escrig A, Rincón M, Pulido R, Saura-Calixto F. Guava fruit (Psidium guajava L.) as a new source of antioxidant dietary fiber. J Agric Food Chem 2001;49:5489-93. doi: 10.1021/jf010147p, PMID 11714349
BDMTM, Biblioteca Digital de la Medicina Tradicional Mexicana. Universidad Autónoma de México; 1999.
Morton JF. Fruits of Warm Climates. CAB Direct; 1987. p. 517.
Burkill HM. The Useful Plants of West Tropical. 2nd ed. Gard Kew, UK: Afr Rev Bot; 1985. p. 4-8.
Villamar AA, Asseleih LM, Rodarte ME. Ahuehuete. Atlas Plant Med Trad Mex 1994;I:61-2.
Okuda T, Hatano T, Yazaki K, Guavin B. Guavin B, an ellagitannin of novel type. Chem Pharm Bull (Tokyo) 1984;32(9):3787-8. doi: 10.1248/cpb.32.3787, PMID 6525667
Yamashiro S, Noguchi K, Matsuzaki T, Miyagi K, Nakasone J, Sakanashi M, et al. Cardioprotective effects of extracts from Psidium guajava L. and Limonium wrightii, Okinawan Medicinal Plants, against ischemia-reperfusion injury in perfused rat hearts. Pharmacology 2003;67:128-35. doi: 10.1159/000067799, PMID 12571408
Thaipong K, Boonprakob U, Cisneros-Zevallos L, Byrne DH. Hydrophilic and lipophilic antioxidant activities of guava fruits. Southeast Asian J Trop Med Public Health 2005;36;Suppl 4:254-7. PMID 16438219
Liang Q, Qian H, Yao W. Identification of flavonoids and their glycosides by high-performance liquid chromatography with electrospray ionization mass spectrometry and with diode array ultraviolet detection. Eur J Mass Spectrom (Chichester) 2005;11:93- 101. doi: 10.1255/ejms.710, PMID 15947448
Zhou L, Li D, Wang J, Liu Y, Wu J. Antibacterial phenolic compounds from the spines of Gleditsia sinensis Lam. Nat Prod Res 2007;21:283- 91. doi: 10.1080/14786410701192637, PMID 17479415
Zhu M, Phillipson JD, Greengrass PM, Bowery NE, Cai Y. Plant polyphenols: biologically active compounds or non-selective binders to protein? Phytochemistry 1997;44:441-7. doi: 10.1016/s0031- 9422(96)00598-5, PMID 9014370
Misra K, Seshadri TR. Chemical components of the fruits of Psidium guava. Phytochemistry 1968;7:641-5. doi: 10.1016/S0031- 9422(00)88240-0
Qian H, Nihorimbere V. Antioxidant power of phytochemicals from Psidium guajava leaf. J Zhejiang Univ Sci 2004;5:676-83. doi: 10.1007/ BF02840979, PMID 15101101
Ojewole JA. Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice. Methods Find Exp Clin Pharmacol 2006;28:441-6. doi: 10.1358/ mf.2006.28.7.1003578, PMID 17003849
Zhang WJ, Chen BT, Wang CY, Zhu QH, Mo ZX. Mechanism of quercetin as an antidiarrheal agent. Di Yi Jun Yi Da Xue Xue Bao 2003;23:1029-31. PMID 14559685
Formica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 1995;33:1061-80. doi: 10.1016/0278-6915(95)00077-1, PMID 8847003
Duarte J, Pérez-Vizcaíno F, Zarzuelo A, Jiménez J, Tamargo J. Vasodilator effects of quercetin in isolated rat vascular smooth muscle. Eur J Pharmacol 1993;239:1-7. doi: 10.1016/0014-2999(93)90968-n, PMID 8223884
Nadkarni KM. Indian materia medica with ayurvedic, Una ni-Tibbi, Siddka. In: Homeopath Naturopathic Home Rem Appendices & Indexes. Homeopathy. 3rd ed. 2014. p. 811-6. Available from: https://// www:4ttopathic.
Husain A. Status Report on Cultivation of Medicinal Plants in NAM Countries. Asiatic Society; 1992; 1: 105.
Arima H, Danno G. Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Biosci Biotechnol Biochem 2002;66:1727-30. doi: 10.1271/bbb.66.1727, PMID 12353635
Kim SS, Oh OJ, Min HY, Park EJ, Kim Y, Park HJ, et al. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci 2003;73:337- 48. doi: 10.1016/s0024-3205(03)00288-1, PMID 12757841
Gutiérrez RM, Mitchell S, Solis RV. Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. Researchgate 2008;117:1-27. doi: 10.1016/j.jep.2008.01.025, PMID 18353572%0Ahttps:
Jang M, Jeong SW, Cho SK, Yang HJ, Yoon DS, Kim JC, et al. Improvement in the anti-inflammatory activity of guava (Psidium guajava L.) leaf extracts through optimization of extraction conditions. J Funct Foods 2014;10:161-8. doi: 10.1016/j.jff.2014.06.006
Olajide OA, Makinde JM, Awe SO. Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. J Ethnopharmacol 1999;66:113-7. doi: 10.1016/s0378-8741(99)00006-9, PMID 10432217
Narayana N. The wealth of India: A dictionary of Indian raw materials & industrial products. NISCIR 1992;I:188.
Vogel HG, Braddock M. Antiarthrotic activity. In: Drug Discovery and Evaluation: Pharmacological Assay. 4th ed. 2015;1: p. 2033-89.
Medzhitov R. Origin and physiological roles of inflammation. Nature 2008;454:428-35. doi: 10.1038/nature07201, PMID 18650913
Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol 2007;147:227-35. doi: 10.1111/j.1365- 2249.2006.03261.x, PMID 17223962
Fujiwara N, Kobayashi K. Macrophages in inflammation. Curr Drug Targets Inflam Allergy 2005;4:281-6. doi: 10.2174/1568010054022024
Bhattachar S. Natural antimutagens: A review. Res J Med Plants 2011;5:116-26. doi: 10.3923/rjmp.2011.116.126
Asija R, Kumawat RS, Asija S, Sharma D, Baheti H. Anti inflammatory and analgesic activity of medicinal plants – A review. Int J Pharm Erud 2014;4:22-32.
Choi JH, Park BH, Kim HG, Hwang YP, Han EH, Jin SW, et al. Inhibitory effect of Psidium guajava water extract in the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Food Chem Toxicol 2012;50:2923-9. doi: 10.1016/j.fct.2012.04.044, PMID 22609491
Tona L, Kambu K, Ngimbi N, Mesia K, Penge O, Lusakibanza M, et al. Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo. Phytomedicine 2000;7:31-8. doi: 10.1016/S0944-7113(00)80019-7, PMID 10782488
Ajaiyeoba EO, Abiodun OO, Falade MO, Ogbole NO, Ashidi JS, Happi CT, et al. In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine. Phytomedicine 2006;13:295-8. doi: 10.1016/j.phymed.2005.01.015, PMID 16492535
Ponce-Macotela M, Navarro-Alegría I, Martínez-Gordillo MN, Alvarez-Chacón R. In vitro effect against Giardia of 14 plant extracts. Rev Invest Clin 1994;46:343-7. PMID 7839013
Nundkumar N, Ojewole JA. Studies on the antiplasmodial properties of some South African medicinal plants used as antimalarial remedies in Zulu folk medicine. Methods Find Exp Clin Pharmacol 2002;24:397- 401. doi: 10.1358/mf.2002.24.7.696540, PMID 12428427
Gessler MC, Nkunya MH, Mwasumbi LB, Heinrich M, Tanner M. Screening Tanzanian medicinal plants for antimalarial activity. Acta Trop 1994;56:65-77. doi: 10.1016/0001-706x(94)90041-8, PMID 8203297
Hepper FN. Numerical analysis of the ‘Flora of West Tropical Africa’: II: Angiosperms (Monocotyledons). Kew Bull 1972;27:305-7. doi: 10.2307/4109458
Rattanachaikunsopon P, Phumkhachorn P. Contents and antibacterial activity of flavonoids extracted from leaves of Psidium guajava. J Med Plants Res 2010;4:393-6.
Garode A. Antibacterial activity of Psidium guajava Linn (Guava) Leaves extracts on bacterial pathogens. Int J Bioassays 2014;1:1794-6.
Mahfuzul Hoque MD, Bari ML, Inatsu Y, Juneja VK, Kawamoto S. Antibacterial activity of guava (Psidium guajava L.) and Neem (Azadirachta indica A. Juss.) extracts against foodborne pathogens and spoilage bacteria. Foodborne Pathog Dis 2007;4:481-8. doi: 10.1089/ fpd.2007.0040, PMID 18041957
Nair R, Chanda S. In-vitro antimicrobial activity of Psidium guajava L. leaf extracts against clinically important pathogenic microbial strains. Braz J Microbiol 2007;38:452-8. doi: 10.1590/ S1517-83822007000300013
Limsong J, Benjavongkulchai E, Kuvatanasuchati J. Inhibitory effect of some herbal extracts on adherence of Streptococcus mutans. J Ethnopharmacol 2004;92:281-9. doi: 10.1016/j.jep.2004.03.008, PMID 15138013
Akinjogunla OJ, Eghafona NO, Enabulele IO, Mboto CI, Ogbemudia FO. Antibacterial activity of ethanolic extracts of Phyllanthus amarus against extended spectrum βlactamase producing Escherichia coli isolated from stool samples of HIV sero-positive patients with or without diarrhoea. Afr J Pharm Pharmacol 2010;4:402-7.
Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12:564-82. doi: 10.1128/CMR.12.4.564, PMID 10515903
Joseph B, Mini PR. Review on nutritional, medicinal and pharmacological properties of Guava (Psidium guajava Linn.). Int J Pharm Biol Sci 2011;2:53-69.
Sanches NR, Garcia Cortez DA, Schiavini MS, Nakamura CV, Dias Filho BP. An evaluation of antibacterial activities of Psidium guajava (L.). Braz Arch Biol Technol 2005;48:429-36. doi: 10.1590/S1516- 89132005000300014
Achudhan VV. Antimicrobial and phytochemical investigation of the leaves of Carica papaya L., Cynodon dactylon (L.) Pers., Euphorbia hirta L., Melia azedarach L. and Psidium guajava L. Ethnobot Leafl 2008;12:1184-91.
Abubakar EM. The use of Psidium guajava Linn. in treating wound, skin and soft tissue infections. Sci Res Essays 2009;4:605-11.
Anas K, Jayasree PR, Vijayakumar T, Manish Kumar PRM. In vitro antibacterial activity of Psidium guajava Linn. leaf extract on clinical isolates of multidrug resistant Staphylococcus aureus. Indian J Exp Biol 2008;46:41-6. PMID 18697570
Akinpelu D, Onakoya T. Antimicrobial activities of medicinal plants used in folklore remedies in south-western. Afr J Biotechnol 2006;5:1078-81.
Dhiman A, Nanda A, Ahmad S, Narasimhan B. In vitro antimicrobial activity of methanolic leaf extract of Psidium guajava L. J Pharm Bioallied Sci 2011;3:226-9. doi: 10.4103/0975-7406.80776, PMID 21687350
Taura DT, Lawan S, Gumel SM, Umar S, Sadisu UF. Antibacterial activity of ethanolic extract of Zingiber officinale and Pipper nigrum against some clinical isolates. Commun Appl Sci ISSN 2014;2:52-64.
Dada EO, Ekundayo FO, Makanjuola OO. Antibacterial activities of Jatropha curcas (LINN) on coliforms isolated from surface waters in Akure, Nigeria. Int J Biomed Sci 2014;10:25-30. PMID 24711746
Muhammad Abubakar EM. Antibacterial activity of crude extracts of Euphorbia hirta against some bacteria associated with enteric infections. J Med Plants Res 2009;3:498-505.
Pachanawan A, Phumkhachorn P, Rattanachaikunsopon P. Potential of Psidium guajava supplemented fish diets in controlling Aeromonas hydrophila infection in tilapia (Oreochromis niloticus). J Biosci Bioeng 2008;106:419-24. doi: 10.1263/jbb.106.419, PMID 19111636
Rahim N, Gomes DJ, Watanabe H, Rahman SR, Chomvarin C, Endtz HP, et al. Antibacterial activity of Psidium guajava leaf and bark against multidrug-resistant Vibrio cholerae: Implication for cholera control. Jpn J Infect Dis 2010;63:271-4. doi: 10.7883/yoken.63.271, PMID 20657067
Belemtougri RG, Constantin B, Cognard C, Raymond G, Sawadogo L. 4Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture. J Zhejiang Univ Sci B 2006;7:56-63. doi: 10.1631/jzus.2006.B0056, PMID 16365927
Yin XL, Li ZJ, Yang K, Lin HZ, Guo ZX. Effect of guava leaves on growth and the non-specific immune response of Penaeus monodon. Fish Shellfish Immunol 2014;40:190-6. doi: 10.1016/j.fsi.2014.07.001, PMID 25010674
Adeyemi OS, Akanji MA. Psidium guajava leaf extract: Effects on rat serum homeostasis and tissue morphology. Comp Clin Pathol 2012;21:401-7. doi: 10.1007/s00580-010-1106-2
Akanji MA, Adeyemi OS, Oguntoye SO, Sulyman F. Psidium guajava extract reduces trypanosomosis Associated lipid peroxidation and raises glutathione concentrations in infected animals. Excli J 2009;8:148-54.
Gupta P, Birdi T. Psidium guajava leaf extract prevents intestinal colonization of Citrobacter rodentium in the mouse model. J Ayurveda Integr Med 2015;6:50-2. doi: 10.4103/0975-9476.146557, PMID 25878465
Geidam YA, Ambali AG, Onyeyili PA, Tijjani MB, Gambo HI, Gulani IA. Antibacterial efficacy of ethyl acetate fraction of Psidium guajava leaf aqueous extract on experimental Escherichia coli (O78) infection in chickens. Vet World 2015;8:358-62. doi: 10.14202/ vetworld.2015.358-362, PMID 27047097
Shittu OB, Ajayi OL, Bankole SO, Popoola TOS. Intestinal ameliorative effects of traditional Ogi-tutu, Vernonia amygdalina and Psidium guajava in mice infected with Vibrio cholera. Afr Health Sci 2016;16:620-8. doi: 10.4314/ahs.v16i2.33, PMID 27605980
Yadav A, Tangpu T. Anticestodal efficacy of Psidium guajava against experimental Hymenolepis diminuta infection in rats. Indian J Pharmacol 2006;38:29-32. doi: 10.4103/0253-7613.19849
Dixon BR, Arai HP. Anthelmintic-induced destrobilation and its influence on calculated drug efficacy in Hymenolepis diminuta infections in rats. J Parasitol 1991;77:769-74. doi: 10.2307/3282714, PMID 1919927
Shruthi SD; ARSSTSS. A review on the medicinal plant Psidium guajava Linn. (Myrtaceae). J Drug Deliv Ther 2013;3:162-8.
Campos JM, Davide LC, Soares GL, Viccini LF. Mutagenic effects due to allelopathic action of fern (Gleicheniaceae) extracts. Allelopath J 2008;22:143-51.
Ross IA, Ross IA. Medicinal plants of the world. In: Chemical Constituents, Traditional and Modern Medicinal Uses. Daucus carota’’L. 2005;3:197-221.
Lutterodt GD. Inhibition of gastrointestinal release of acetylchoune byquercetin as a possible mode of action of Psidium guajava leaf extracts in the treatment of acute diarrhoeal disease. J Ethnopharmacol 1989;25:235-47. doi: 10.1016/0378-8741(89)90030-5, PMID 2747259
Lutterodt GD. Inhibition of microlax-induced experimental diarrhoea with narcotic-like extracts of Psidium guajava leaf in rats. J Ethnopharmacol 1992;37:151-7. doi: 10.1016/0378-8741(92)90073-z, PMID 1434689
Nweze E, Okafor J, Njoku O. Antimicrobial activities of methanolic extracts of Trema guineensis (Schumm and Thorn) and Morinda lucida Benth. Used in Nigerian. Biol Res 2004;2:39-46.
Gayathri M, Kannabiran K. Antimicrobial activity of Hemidesmus indicus, Ficus bengalensis and Pterocarpus marsupium roxb. Indian J Pharm Sci 2009;71:578-81. doi: 10.4103/0250-474X.58182, PMID 20502584
Etuk EU, Ugwah MO, Ajagbonna OP, Onyeyili PA. Ethnobotanical survey and preliminary evaluation of medicinal plants with antidiarrhoea properties in Sokoto state, Nigeria. J Med Plants Res 2009;3:763-6.
Mukherjee PK, Das J, Balasubramanian R, Saha K, Pal M, Saha BP. Antidiarrhoeal evaluation of Nelumbo nucifera rhizome extract. Indian J Pharmacol 1995;27:262-4.
Galvez J, Zarzuelo A, Crespo ME, Lorente MD, Ocete MA, Jiménez J. Antidiarrhoeic activity of Euphorbia hirta extract and isolation of an active flavonoid constituent. Planta Med 1993;59:333-6. doi: 10.1055/ s-2006-959694, PMID 8372151
Otshudi AL, Foriers A, Vercruysse A, Van Zeebroeck A, Lauwers S. In vitro antimicrobial activity of six medicinal plants traditionally used for the treatment of dysentery and diarrhoea in Democratic Republic of the Congo (DRC). Phytomedicine 2000;7:167-72. doi: 10.1016/s0944- 7113(00)80090-2, PMID 10839221
Gonçalves JL, Lopes RC, Oliveira DB, Costa SS, Miranda MM, Romanos MT, et al. In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea. J Ethnopharmacol 2005;99:403-7. doi: 10.1016/j.jep.2005.01.032, PMID 15876501
Wei L, Li Z, Chen B. Clinical study on treatment of infantile rotaviral enteritis with Psidium guajava L. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20:893-5. PMID 11938857
Bae EA, Han MJ, Lee M, Kim DH. In vitro inhibitory effect of some flavonoids on rotavirus infectivity. Biol Pharm Bull 2000;23:1122-4. doi: 10.1248/bpb.23.1122, PMID 10993220
Metwally AM, Omar AA, Harraz FM, El Sohafy SM. Phytochemical investigation and antimicrobial activity of Psidium guajava L. leaves. Pharmacogn Mag 2010;6:212-8. doi: 10.4103/0973-1296.66939, PMID 20931082
Mukhtar HM, Ansari SH, Ali M, Naved T, Bhat ZA. Anti-hyperglycemic activity of Psidium guajava bark extract. J Nat Rem 2004;4:150-4.
Khaleel Basha S, Govindaraju K, Manikandan R, Ahn JS, Bae EY, Singaravelu G. Phytochemical mediated gold nanoparticles and their PTP 1B inhibitory activity. Colloids Surf B Biointerfaces 2010;75:405- 9. doi: 10.1016/j.colsurfb.2009.09.008, PMID 19815393
Pari L, Maheswari JU. Hypoglycaemic effect of Musa sapientum L. in alloxan-induced diabetic rats. J Ethnopharmacol 1999;68:321-5. doi: 10.1016/s0378-8741(99)00088-4, PMID 10624895
Obatomi DK, Bikomo EO, Temple VJ. Anti-diabetic properties of the African mistletoe in streptozotocin-induced diabetic rats. J Ethnopharmacol 1994;43:13-7. doi: 10.1016/0378-8741(94)90111- 2, PMID 7967645
Rai PK, Rai NK, Rai AK, Watal G. Role of LIBS in elemental analysis of Psidium guajava responsible for glycemic potential. Instrum Sci Technol 2007;35:507-22. doi: 10.1080/10739140701540230
Gray AM, Abdel-Wahab YH, Flatt PR. The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. J Nutr 2000;130:15-20. doi: 10.1093/jn/130.1.15, PMID 10613759
Mittal P, Gupta V. Phytochemistry and pharmacological activities of Psidium guajava: A review. J Pharm Sci Res 2010;1:9-19.
Liu CH, Peng CC, Peng CH, Hsieh CL, Chen KC, Peng RY. Polyphenolics-rich Psithum guajava budding leaf extract can reverse diabetes-induced functional impairment of cavernosal smooth muscle relaxation in rats. Res J Med Sci 2010;4:25-32. doi: 10.3923/ rjmsci.2010.25.32
Soman S, Rauf AA, Indira M, Rajamanickam C. Antioxidant and antiglycative potential of ethyl acetate fraction of Psidium guajava Leaf extract in streptozotocin-induced diabetic rats. Plant Foods Hum Nutr 2010;65:386-91. doi: 10.1007/s11130-010-0198-9, PMID 21120613
Wu JW, Hsieh CL, Wang HY, Chen HY. Inhibitory effects of guava (Psidium guajava L.) leaf extracts and its active compounds on the glycation process of protein. Food Chem 2009;113:78-84. Available from: wos:000260711100012. doi: 10.1016/j.foodchem.2008.07.025
Wang H, Du YJ, Song HC. α-glucosidase and α-amylase inhibitory activities of guava leaves. Food Chem 2010;123:6-13. doi: 10.1016/j. foodchem.2010.03.088
Deguchi Y, Miyazaki K. Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract. Nutr Metab (Lond) 2010;7:9. doi: 10.1186/1743-7075-7-9, PMID 20181067
Zhang Z, Kong F, Ni H, Mo Z, Wan JB, Hua D, et al. Structural characterization, α-glucosidase inhibitory and DPPH scavenging activities of polysaccharides from guava. Carbohydr Polym 2016;144:106-14. doi: 10.1016/j.carbpol.2016.02.030, PMID 27083799
Eidenberger T, Selg M, Krennhuber K. Inhibition of dipeptidyl peptidase activity by flavonol glycosides of guava (Psidium guajava L.): A key to the beneficial effects of guava in type II diabetes mellitus. Fitoterapia 2013;89:74-9. doi: 10.1016/j.fitote.2013.05.015, PMID 23707747
Lee Y, Lim Y, Kwon O. Selected phytochemicals and culinary plant extracts inhibit fructose uptake in caco-2 cells. Molecules 2015;20:17393-404. doi: 10.3390/molecules200917393, PMID 26393568
Cheng FC, Shen SC, Wu JS-B. Effect of guava (Psidium guajava L.) leaf extract on glucose uptake in rat hepatocytes. J Food Sci 2009;74:H132-8. doi: 10.1111/j.1750-3841.2009.01149.x, PMID 19646046
Basha SK, Kumari VS. In vitro antidiabetic activity of Psidium guajava leaves extracts. Asian Pac J Trop Dis 2012;2 Suppl 1:S98- 100. doi: 10.1016/S2222-1808(12)60131-5
Yoshitomi H, Qin L, Liu T, Gao M. Guava leaf extracts inhibit 3T3-L1 adipocyte differentiation via activating AMPK. J Nutr Ther 2012;1:107-13.
Chang WC, Shen SC. Effect of water Extracts from Edible Myrtaceae Plants on Uptake of 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)- 2-deoxyglucose in TNF-alpha-Treated FL83B Mouse Hepatocytes. Phytother Res 2013;27:236-43. doi: 10.1002/ptr.4681, PMID 22532499
Anand S, Arasakumari M, Prabu P, Amalraj AJ. Anti-diabetic and aldose reductase inhibitory potential of Psidium guajava by in vitro analysis. Int J Pharm Pharm Sci 2016;8:271-6. doi: 10.22159/ ijpps.2016.v8i9.13532
Kamath J, Rahul N, Kumar CA, Lakshmi S. Psidium guajava L.: A review. Int J Green Pharm 2008;1:9.
Lozoya X, Reyes-Morales H, Chávez-Soto MA, Martínez-García Mdel C, Soto-González Y, Doubova SV. Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease. J Ethnopharmacol 2002;83:19-24. doi: 10.1016/s0378-8741(02)00185-x, PMID 12413703
Yen GC, Chen HY. Antioxidant activity of various tea extracts in relation to their Antimut agenicity. J Agric Food Chem 1995;43:27- 32. doi: 10.1021/jf00049a007
Chen KC, Hsieh CL, Peng CC, Hsieh-Li HM, Chiang HS, Huang KD, et al. Brain derived metastatic prostate cancer DU-145 cells are effectively inhibited in vitro by guava (Psidium gujava L.) leaf extracts. Nutr Cancer 2007;58:93-106. doi: 10.1080/01635580701308240, PMID 17571972
Milyani R. Inhibitory effect of some plant extracts on clinical isolates of Staphylococcus aureus. Afr J Microbiol Res 2012;6:6517-24. doi: 10.5897/AJMR11.119
Chah KF, Eze CA, Emuelosi CE, Esimone CO. Screening for antiviral effect of Thai herbs; Kaempferia parviflora, Ellipeiopsis cherrevensis and Stemona tuberosa against dengue virus type-2. J Ethnopharmacol 2006;104:164-7. doi: 10.1016/j.jep.2005.08.070, PMID 16226414
Fernandes MR, Dias AL, Carvalho RR, Souza CR, Oliveira WP. Antioxidant and antimicrobial activities of Psidium guajava L. spray dried extracts. Ind Crops Prod 2014;60:39-44. doi: 10.1016/j. indcrop.2014.05.049
De Araújo AA, Soares LA, Assunção Ferreira MR, De Souza Neto MA, Da Silva GR, De Araújo RF, et al. Quantification of polyphenols and evaluation of antimicrobial, analgesic and anti-inflammatory activities of aqueous and acetone-water extracts of Libidibia ferrea, Parapiptadenia rigida and Psidium guajava. J Ethnopharmacol 2014;156:88-96. doi: 10.1016/j.jep.2014.07.031, PMID 25124277
Morais-Braga MF, Sales DL, dos Santos Silva F, Chaves TP, de Carvalho Nilo Bitu V, Avilez WM, et al. Psidium guajava L. and Psidium brownianum Mart ex DC. potentiate the effect of antibiotics against Gram-positive and Gram-negative bacteria. Eur J Integr Med 2016;8:683-7. doi: 10.1016/j.eujim.2016.07.001
Betoni JE, Mantovani RP, Barbosa LN, Di Stasi LC, Fernandes Junior A. Synergism between plant extract and antimicrobial drugs used on Staphylococcus aureus diseases. Mem Inst Oswaldo Cruz 2006;101:387-90. doi: 10.1590/s0074-02762006000400007, PMID 16951808
Mailoa MN, Mahendradatta M, Laga A, Djide N. Antimicrobial activities of tannins extract from guava leaves (Psidium guajava L.) on pathogens microbial. Int J Sci Technol Res 2014;3:236-41.
Ghosh P, Mandal A, Chakraborty P, Rasul MG, Chakraborty M, Saha A. Triterpenoids from Psidium guajava with biocidal activity. Indian J Pharm Sci 2010;72:504-7. doi: 10.4103/0250-474X.73936, PMID 21218065
Zahir AA, Rahuman AA, Bagavan A, Santhoshkumar T, Mohamed RR, Kamaraj C, et al. Evaluation of botanical extracts against Haemaphysalis bispinosa Neumann and Hippobosca maculata Leach. Parasitol Res 2010;107:585-92. doi: 10.1007/ s00436-010-1898-7, PMID 20467752
Adeyemi OS, Sykes ML, Akanji MA, Avery VM. Anti-trypanosomal and cytotoxic activity of ethanolic extracts of Psidium guajava leaves in Alamar Blue based assays. Vet Arh 2011;81:623-33.
Kaushik NK, Bagavan A, Rahuman AA, Zahir AA, Kamaraj C, Elango G, et al. Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats. Malar J 2015;14:65. doi: 10.1186/s12936-015-0564-z, PMID 25879738
Lee WC, Mahmud R, Noordin R, Pillai Piaru S, Perumal S, Ismail S. Free radicals scavenging activity, cytotoxicity and anti-parasitic activity of essential oil of Psidium guajava L. Leaves against Toxoplasma gondii. J Essent Oil Bear Plants 2013;16:32-8. doi: 10.1080/0972060X.2013.764196
Thiyagarajan S, Jamal A. Evaluation of lethal activity of Psidium guajava LINN. Extracts on bacterial pathogens causing diarrheal infections. Int J Res Ayurveda Pharm 2015;6:111-7. doi: 10.7897/2277-4343.06124
Rubee Chanu T, Pai V, Chakraborty R, Raju B, Lobo R, Ballal M. Screening for antidiarrheal activity of Psidium guajava: A possible alternative in the treatment against diarrhea causing enteric pathogens. J Chem Pharm Res 2011;3:961-7.
Birdi T, Daswani P, Brijesh S, Tetali P, Natu A, Antia N. Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea. BMC Complement Altern Med 2010;10:33. doi: 10.1186/1472-6882-10-33, PMID 20584265
Gonçalves FA, Andrade Neto M, Bezerra JN, Macrae A, De Sousa OV, Fonteles-Filho AA, et al. Antibacterial activity of guava, Psidium guajava Linnaeus, leaf extracts on diarrhea-causing enteric bacteria isolated from seabob shrimp, Xiphopenaeus kroyeri (Heller). Rev Inst Med Trop Sao Paulo 2008;50:11-5. doi: 10.1590/s0036- 46652008000100003, PMID 18327481
Samson ES, Ehizibue OP, Ngozi AE, Richard AY, Omolara OT. Evaluation of the antimicrobial potential of Gongronema latifolium extracts on some wound-associated pathogens. Open Sci J Pharm Pharmacol 2017;5:34-41.
Nisha K, Darshana M, Madhu G, Bhupendra MK. GC-MS analysis and antimicrobial activity of Psidium guajava (leaves) grown in Malva region of India. Int J Drug Dev Res 2011;3:237-45.
Sriwilaijaroen N, Fukumoto S, Kumagai K, Hiramatsu H, Odagiri T, Tashiro M, et al. Antiviral effects of Psidium guajava Linn. (guava) tea on the growth of clinical isolated H1N1 viruses: Its role in viral hemagglutination and neuraminidase inhibition. Antiviral Res 2012;94:139-46. doi: 10.1016/j.antiviral.2012.02.013, PMID 22453134
Wang B, Jiao S, Liu H, Hong J. Study on antioxidative activities of Psidium guajava Linn leaves extracts. Wei Sheng Yan Jiu J Hyg Res 2007;36:298-300.
Conde Garcia EA, Nascimento VT, Santiago Santos AB. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium. Braz J Med Biol Res 2003;36:661-8. doi: 10.1590/s0100- 879x2003000500014, PMID 12715086
Mukhtar HM, Ansari SH, Bhat ZA, Naved T, Singh P. Antidiabetic activity of an ethanol extract obtained from the stem bark of Psidium guajava (Myrtaceae). Pharmazie 2006;61:725-7. PMID 16964719
Abdelrahim SI, Almagboul AZ, Omer ME, Elegami A. Antimicrobial activity of Psidium guajava L. Fitoterapia 2002;73:713-5. doi: 10.1016/s0367-326x(02)00243-5, PMID 12490238
Roy CK, Kamath JV, Asad M. Hepatoprotective activity of Psidium guajava Linn. leaf extract. Indian J Exp Biol 2006;44:305-11. PMID 16629373
Ojewole JA, Awe EO, Chiwororo WD. Antidiarrhoeal activity of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rodents. J Smooth Muscle Res 2008;44:195-207. doi: 10.1540/jsmr.44.195, PMID 19234374
Akinola OB, Oladosu OS, Dosumu OO. Ethanol extract of the leaves of Psidium guajava Linn enhances sperm output in healthy Wistar rats. Afr J Med Med Sci 2007;36:137-40. PMID 19205576
Grover IS, Bala S. Studies on antimutagenic effects of guava (Psidium guajava) in Salmonella typhimurium. Mutat Res 1993;300:1-3. doi: 10.1016/0165-1218(93)90133-x, PMID 7683763
Lozoya X, Meckes M, Abou-Zaid M, Tortoriello J, Nozzolillo C, Arnason JT. Quercetin glycosides in Psidium guajava L. leaves and determination of a spasmolytic principle. Arch Med Res 1994;25:11- 5. PMID 8019108
Chen KC, Peng CC, Chiu WT, Cheng YT, Huang GT, Hsieh CL, et al. Action mechanism and signal pathways of Psidium guajava L. aqueous extract in killing prostate cancer LNCaP cells. Nutr Cancer 2010;62:260-70. doi: 10.1080/01635580903407130, PMID 20099201
Joseph B, Priya R, Helen P, Sujatha S. Bioactive compounds in essential oil and its effects of antimicrobial, cytotoxicactivity from the Psidium guajava (L.) leaf. J Adv Biotechnol 2010 ;9:10-4.
Shaheen HM, Ali BH, Alqarawi AA, Bashir AK. Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. Phytother Res 2000;14:107-11. doi: 10.1002/(sici)1099- 1573(200003)14:2<107:aid-ptr602>3.0.co;2-z, PMID 10685107
Kaileh M, Vanden Berghe W, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol 2007;113:510-6. doi: 10.1016/j.jep.2007.07.008, PMID 17716845
Qadan F, Thewaini AJ, Ali DA, Afifi R, Elkhawad A, Matalka KZ. The antimicrobial activities of Psidium guajava and Juglans regia leaf extracts to acne-developing organisms. Am J Chin Med 2005;33:197- 204. doi: 10.1142/S0192415X05002783, PMID 15974479
Kawakami Y, Nakamura T, Hosokawa T, Suzuki-Yamamoto T, Yamashita H, Kimoto M, et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. Prostaglandins Leukot Essent Fatty Acids 2009;80:239-45. doi: 10.1016/j.plefa.2009.04.006, PMID 19457650
Olajide OA, Awe SO, Makinde JM. Pharmacological studies on the leaf of Psidium guajava. Fitoterapia 1999;70:25-31. doi: 10.1016/ S0367-326X(98)00010-0
Olatunji-Bello II, Odusanya AJ, Raji I, Ladipo CO. Contractile effect of the aqueous extract of Psidium guajava leaves on aortic rings in rat. Fitoterapia 2007;78:241-3. doi: 10.1016/j.fitote.2006.11.007, PMID 17346902
Nweze N. Onyekwere1 and Nwafor FI. Phytochemical, proximate and mineral composition of leaf extracts of Moringa oleifera Lam. from Nsukka, South-Eastern Nigeria. IOSR JPBS 2014;7676:2319.
Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Pharmacol 2006;147 Suppl 1:S232-40. doi: 10.1038/sj.bjp.0706400, PMID 16402109
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