A REVIEW ON TRANSDERMAL PATCHES USED AS AN ANTI-INFLAMMATORY AGENT
DOI:
https://doi.org/10.22159/ajpcr.2021.v14i12.43277Keywords:
Transdermal patch, Non-steroidal anti-inflammatory drugs, Repaglinide, Diclofenac sodium, InflammationAbstract
The transdermal drug delivery system is widely accepted due to its numerous advantages as it is a non-invasive drug administration process with prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance, and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs such as Diclofenac sodium, Lornoxicam, Aceclofenac, Ibuprofen, antihypertensive drugs, for example, Repaglinide, Atenolol, and Antiviral agents such as Stavudine, zidovudine represents the most commonly used medications for the treatment of pain and inflammatory reaction but various side effects can limit their use. Therefore, transdermal delivery of these drugs has advantages of avoiding hepatic first-pass effect, gastric irritation and delivering the drug for an extended period of time at a sustained level. The present article mainly focuses on the work been done on these drugs by formulated and delivered as transdermal patches to decrease the side effects related to the oral delivery.
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References
Chen L, Deng H, Cui H, Fang J, Zuo Z. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 2018;9:7204-18.
Sogaard K, Sjogaard G. Physical activity as cause and cure of muscular pain: Evidence of underlying mechanisms. Exerc Sport Sci Rev 2017;45:136-45.
Pascottini OB, Spricigo JF, Van Schyndel SJ, Mion B, Rousseau J, Weese JS, et al. Effects of parity, blood progesterone, and non-steroidal anti-inflammatory treatment on the dynamics of the uterine microbiota of healthy postpartum dairy cows. PLoS One 2021;16:e0233943.
Sharma CS, Khandelwal M. A novel transdermal drug-delivery patch for treating local muscular pain. Ther Deliv 2018;9:405-7.
Diwan V, Srinivasa TS, Ramreddy KY, Agrawal V, Nagdeve S, Parvez H. A comparative evaluation of transdermal diclofenac patch with oral diclofenac sodium as an analgesic drug following periodontal flap surgery: A randomized controlled clinical study. Indian J Dent Res 2019;30:57-60.
Gunter BR, Butler KA, Wallace RL, Smith SM, Harirforoosh S. Non-steroidal anti-inflammatory drug-induced cardiovascular adverse events: A meta-analysis. J Clin Pharm Ther 2017;42:27-38.
Zhang D, Bian Q, Zhou Y, Huang Q, Gao J. The application of label-free imaging technologies in transdermal research for deeper mechanism revealing. Asian J Pharm Sci 2021;16:265-79.
Hua S. Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration. Front Pharmacol 2019;10:1-9.
Xie Y, Shao R, Lin Y, Wang C, Tan Y, Xie W, et al. Improved therapeutic efficiency against obesity through transdermal drug delivery using microneedle arrays. Pharmaceutics 2021;13:827.
He X, Sun J, Zhuang J, Xu H, Liu Y. Microneedle system for transdermal drug and vaccine delivery: Devices, safety, and prospects. Dose Response 2019;17:1559325819878585.
Pandey PC, Shukla S, Skoog SA, Boehm RD, Narayan RJ. Current advancements in transdermal biosensing and targeted drug deliver. Sensors (Basel) 2019;19:1028.
Grammatikopoulou MG, Gkiouras K, Dardiotis E, Zafiriou E, Tsigalou C, Bogdanos DP. Peeking into the future: Transdermal patches for the delivery of micronutrient supplements. Metabol Open 2021;11:100109.
Szunerits S, Boukherroub R. Heat: A highly efficient skin enhancer for transdermal drug delivery. Front Bioeng Biotechnol 2018;6:15.
Sarveswaran R, Jayasuriya WJ, Suresh TS. In vitro assays to investigate the anti-inflammatory activity of herbal extracts: A review. World J Pharm Res 2017;6:131-41.
Elkoshi Z. The binary classification of chronic diseases. J Inflamm Res 2019;12:319-33.
Nilewar GA, Takdhat PL, Thakre SM, Bhagwatkar PD. Formulation and evaluation of repaglinide transdermal patches for treatment of diabetes. World J Pharm Res 2018;7:1342-53.
Kriplani P, Sharma A, Aman, Pun P, Chopra B, Dhingra A, et al. Formulation and Evaluation of Transdermal Patch of Diclofenac Sodium. Glob J Pharm Pharm Sci 2018;4:1-4.
Saroj AK, Khan R, Sharma B. Transdermal drug delivery system (Patch). World J Pharm Res 2019;8:325-43.
Cherukuri S, Batchu UR, Mandava K, Cherukuri V, Ganapuram KR. Formulation and evaluation of transdermal drug delivery of topiramate. Int J Pharm Investig 2017;7:10-7.
Mahesh G, Kumar KA, Reddanna P. Overview on the discovery and development of anti-inflammatory drugs: Should the focus be on synthesis or degradation of PGE2? J Inflamm Res 2021;14:253-63.
Kar NR. A review on inflammatory bowel disease- recent pharmaceutical approaches to combat it. Int J Pharm Sci Res 2021;12:3593.
Saleem S, Muhammad G, Hussain MA, Abbas Bukhari SN. A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica.Phytother Res 2018;32:1241-72.
Lalitha P, Sachithanandam V, Swarnakumar NS, Sridhar R. Review on anti-inflammatory properties of Mangrove plants. Asian J Pharm Res 2019;9:273-88.
Dasari S, Yedjou CG, Brodell RT, Cruse AR, Tchounwou PB. Therapeutic strategies and potential implications of silver nanoparticles in the management of skin cancer. Nanotechnol Rev 2020;9:1500-21.
Amjadi M, Mostaghaci B, Sitti M. Recent advances in skin penetration enhancers for transdermal gene and drug delivery. Curr Gene Ther 2017;17:139-46.
McEvoy L, Carr DF, Pirmohamed M. Pharmacogenomics of NSAID-induced upper gastrointestinal toxicity. Front Pharmacol 2021;12:684162.
Veettil SK, Lim KG, Ching SM, Saokaew S, Phisalprapa P, Chaiyakunapruk N. Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: A systematic review with meta-analysis and trial sequential analysis of randomized clinical trials. BMC Cancer 2017;17:763.
Rajeswari SR, Gowda T, Kumar T, Mehta DS, Arya K. Analgesic efficacy and safety of transdermal and oral diclofenac in postoperative pain management following dental implant placement. Gen Dent 2017;65:69-74.
Shinde VA, Kalikar M, Jagtap S, Dakhale GN, Bankar M, Bajait CS, et al. Efficacy and safety of oral diclofenac sustained release versus transdermal diclofenac patch in chronic musculoskeletal pain: A randomized, open label trial. J Pharmacol Pharmacother 2017;8:166-71.
Dasgupta S, Ray S, Dey S, Pal P, Mazumder B. Transdermal lipid nanocarriers: A potential delivery system for lornoxicam. Pharm Nanotechnol 2017;5:32-43.
Palei NN, Mohanta BC, Das MK, Sabapathi ML. Lornoxicam loaded nanostructured lipid carriers for top-ical delivery: Optimization, skin uptake and in vivo studies. J Drug Deliv Sci Technol 2017;39:490-500.
Yu YQ, Yang X, Wu XF, Fan YB. Enhancing permeation of drug molecules across the skin via delivery in nanocarriers: Novel strategies for effective transdermal applications. Front Bioeng Biotechnol 2021;9:646554.
Ameen D, Michniak-Kohn B. Development and in vitro evaluation of pressure sensitive adhesive patch for the transdermal delivery of galantamine: Effect of penetration enhancers and crystallization inhibition. Eur J Pharm Biopharm 2019;139:262-71.
Shivakumar HN, Kotian RS. Design and development of transdermal drug delivery of nonsteroidal anti-inflammatory drugs: Lornoxicam 2019;8:277-83.
Yadav AV, Urade MN. Formulation and evaluation of chitosan based transdermal patches of lornoxicam for prolonged drug release and to study the effect of permeation enhancer. Indian J Pharm Educ Res 2019;53:88-96.
Manickam B, Sreedharan R, Chidambaram K. Drug/vehicle impacts and formulation centered stratagems for enhanced transdermal drug permeation, controlled release and safety: Unparalleled past and recent innovations-an overview. Curr Drug Ther 2019;14:192-209.
Puscaselu RG, Lobiuc A, Dimian M, Covasa M. Alginate: From food industry to biomedical applications and management of metabolic disorders. Polymers 2020;12:2417.
Opatha SA, Titapiwatanakun V, Chutoprapat R. Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics 2020;12:855.
Pereira R, Silva SG, Pinheiro M, Reis S, Vale ML. Current status of amino acid-based permeation enhancers in transdermal drug delivery. Membranes (Basel) 2021;11:343.
Ginting E, Reveny J, Sumaiyah. Formulation and evaluation of in vitro transdermal patch diclofenac sodium using chitosan polymer and polyvinyl alcohol cross linked tripolyphosphate sodium. Asian J Pharm Clin Res 2018;11:171-5.
Duriya H, Shoaib MH, Ali FR, Siddiqui F. Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancer. PLoS One 2020;15:1-23.
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol 2018;17:122.
Wang SL, Dong WB, Dong XL. Comparison of twelve single-drug regimens for the treatment of Type 2 diabetes mellitus. Oncotarget 2017;8:72700-13.
Lee YC, Chang CH, Dong YH. Comparing the risks of hospitalized heart failure associated with glinide, sulfonylurea, and acarbose use in Type 2 diabetes: A nationwide study. Int J Cardiol 2017;228:1007-14.
Delvecchio M, Pastore C, Giordano P. Treatment options for MODY patients: A systematic review of literature. Diabetes Ther 2020;11:1667-85.
Mhatre O, Sodha S. Pharmaceutical feasibility and flow characteristics of polymeric non-spherical particles. Nanomedicine 2019;18:243-58.
Reddy PS, Bose PS, Sruthi V, Saritha D. Investigation of Kondagogu gum to develop transdermal film of repaglinide. Asian J Pharm Clin Res 2018;11:440-5.
Tian F, Liu T, Xu G, Li D, Ghazi T, Shick T, et al. Adrenergic blockade bi-directionally and asymmetrically alters functional brain-heart communication and prolongs electrical activities of the brain and heart during asphyxic cardiac arrest. Front Physiol 2018;9:99.
Trivedi V, Arora N, Arora P. Formulation and evaluation of transdermal patches of atenolol. Int J Res Cult Soc 2018;2:13-8.
Grass J, Rose P, Burhenne J, Blank A, Haefeli WE, Mikus G. Absolute bioavailability of microdosed midazolam after buccal administration is dependent on buccal exposure time. J Clin Pharmacol 2021;61:472-9.
Delshadi R, Bahrami A, McClements DJ, Moore MD, Williams L. Development of nanoparticle-delivery systems for antiviral agents: A review. J Control Release 2021;331:30-44.
Ramkanth C, Chetty CM, Sudhakar Y, Thiruvengadarajan VS, Anitha P, Gopinath C. Development, characterization and in vivo evaluation of proniosomal based transdermal delivery system of atenolol. Future J Pharm Sci 2018;4:80-7.
Alkilani AZ, McCrudden MT, Donnelly RF. Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics 2015;7:438-70.
Irvine J, Afrose A, Islam N. Formulation and delivery strategies of ibuprofen: Challenges and opportunities. Drug Dev Ind Pharm 2018;44:173-83.
Kelchen MN, Brogden NK. Effect of dosing regimen and microneedle pretreatment on in vitro skin retention of topically applied beta-blockers. Biomed Microdevices 2018;20:100.
Mahajan NM, Zode GH, Mahapatra DK, Thakre S, Dumore N, Gangane PS. Formulation development and evaluation of transdermal patch of piroxicam for treating dysmenorrhoea. J Appl Pharm Sci 2018;8:35-41.
McCrudden MT, Larrañeta E, Clark A, Jarrahian A, ReinWeston A, Creelman B, et al. Design, formulation, and evaluation of novel dissolving microarray patches containing rilpivirine for intravaginal delivery. Adv Healthc Mater 2019;8:1-12.
Chime SA, Onunkwo GC, Attama AA. Evaluation of the properties of encapsulated stavudine microparticulate lipid-based drug delivery system in immunocompromised wistar rats. Curr HIV Res 2020;18:237-47.
Yamsani VV, Mudulaghar MK, Afreen S, Wajid S, Ravula SK, Babelghaith SD. Formulation design and in vitro ex vivo evaluation of transdermal patches of cinnarizine. Pak J Pharm Sci 2017;30:2075-83.
Samal D, Mishra N, Meher B, Kar IB, Kar R, Saipooja RH. Comparison of safety, efficacy, patient compliance and cost-effectiveness of transdermal, oral and intramuscular diclofenac for pain control following oral surgical procedures. J Maxillofac Oral Surg 2021;20:63-9.
McNicol ED, Ferguson MC, Schumann R. Single-dose intravenous ketorolac for acute postoperative pain in adults. Cochrane Database Syst Rev 2021;5:CD013263.
Kołodziejska J, Kołodziejczyk M. Diclofenac in the treatment of pain in patients with rheumatic diseases. Reumatologia 2018;56:174-83.
Mandal A, Bisht R, Rupenthal ID, Mitra AK. Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies. J Control Release 2017;248:96-116.
Jafri I, Shoaib MH, Yousuf RI, Ali FR. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Dev Ind Pharm 2003;29:495-503.
Marapur SC, Wali DS, Hunasagi BS, Chetankumar M, Patil RG. Formulation and evaluation of transdermal drug delivery system of verapamil hydrochloride. J Drug Deliv Ther 2018;8:70-7.
Deshpande TM, Quadir A, Obara S, Hoag SW. Impact of formulation excipients on the thermal, mechanical, and electrokinetic properties of hydroxypropyl methylcellulose acetate succinate (HPMCAS). Int J Pharm 2018;542:132-41.
Sravanthi K, Reddy DR, Sirisha A, Pavani A, Lakshmi BK, Sowjanya B. Preparation and in vitro evaluation of transdermal patch of aceclofenac. J Pharmtechnol Res 2020;10:175-81.
van Rensburg R, Reuter H. An overview of analgesics: NSAIDs, paracetamol, and topical analgesics. S Afr Family Pract 2019;61:S4-10.
Akram MR, Ahmad M, Abrar A, Sarfraz RM, Mahmood A. Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride. Drug Des Dev Ther 2018;12:349-64.
Mamatha J, Gadili S, Pallavi K. Formulation and evaluation of zidovudine transdermal patch using permeation enhancers. J Young Pharm 2020;12 Suppl 2:S45-50.
Charoensumran P, Ajiro H. Cationic moieties in polystyrene gels swollen with d-limonene improved transdermal delivery system. Polymers (Basel) 2018;10:1200.
Naiserová M, Kubová K, Vysloužil J, Bernatoniene J, Brokalakis I, Vetchý D. (Meth)acrylate copolymers of Eudragit® type in oral tablet technology. Ceska Slov Farm 2019;68:183-97.
Dutta L, Mukherjee B, Chakraborty T, Das MK, Mondal L, Bhattacharya S, et al. Lipid-based nanocarrier efficiently delivers highly water soluble drug across the blood-brain barrier into brain. Drug Deliv 2018;25:504-16.
Bajracharya R, Song JG, Back SY, Han SK. Recent advancements in non-invasive formulations for protein drug delivery. Comput Struct Biotechnol J 2019;17:1290-308.
Ammar HO, Tadros MI, Salama NM, Ghoneim AM. Ethosome- Derived invasomes as a potential transdermal delivery system for vardenafil hydrochloride: Development, Optimization and application of physiologically based pharmacokinetic modeling in adults and geriatrics. Int J Nanomed 2020;15:5671-85.
Tawfik MA, Tadros MI, Mohamed MI, El-Helaly SN. Low-frequency versus high-frequency ultrasound-mediated transdermal delivery of agomelatine-loaded invasomes: Development, optimization and in-vivo pharmacokinetic assessment. Int J Nanomed 2020;15:8893-910.
Lundgren M, Steed LJ, Tamura R, Jonsdottir B, Gesualdo P, Crouch C, et al. Analgesic antipyretic use among young children in the TEDDY study: No association with islet autoimmunity. BMC Pediatr 2017;17:127.
Gyöngyösi A, Verner V, Bereczki I, Kiss-Szikszai A, Zilinyi R, Tósaki A, et al. Basic pharmacological characterization of EV-34, a New H2S-releasing ibuprofen derivative. Molecules 2021;26:599.
Jones P, Lamdin R, Dalziel SR. Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. Cochrane Database Syst Rev 2020;8:CD007789.
Coderch L, Collini I, Carrer V, Barba C, Alonso C. Assessment of finite and infinite dose in vitro experiments in transdermal drug delivery. Pharmaceutics 2021;13:364.
Uchida T, Kadhum WR, Kanai S, Todo H, Oshizaka T, Sugibayashi K. Prediction of skin permeation by chemical compounds using the artificial membrane, Strat-M™. Eur J Pharm Sci 2015;67:113-8.
Tombs EL, Nikolaou V, Nurumbetov G, Haddleton DM. Transdermal delivery of ibuprofen utilizing a novel solvent-free pressure-sensitive adhesive (PSA): TEPI® technology. J Pharm Innov 2018;13:48-57.
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