DESIGN AND EVALUATION OF TORSEMIDE CONTROLLED RELEASE MATRIX TABLETS
Abstract
Â
Objective: The controlled release Torsemide matrix tablets were prepared using different natural polymers in various proportions as release
retarding agents to control the torsemide release and to improve the patient compliance.
Methods: Torsemide matrix tablets were prepared by direct compression method. The matrix tablet is then evaluated for its thickness, hardness,
friability, weight variation, drug content and in vitro release. The compatibility of drug excipients was reviewed using Fourier transform infrared (FTIR)
and differential scanning calorimetry (DSC) studies.
Results: All the torsemide matrix formulations showed compliance with pharmacopoeial standards. Amongst all the formulations, formulation F9
containing pectin (10%) showed controlled drug release (99%) for 13 hrs, emerging as the best formulation. The formulation showed highest r2 value
of 0.9731 for zero order kinetics compared to first order kinetics indicating a drug release independent of concentration of the drug. Mechanism of
drug release of optimized formulation F-9 showed non-Fickian diffusion. FTIR and DSC studies indicated no chemical interaction between the drug
and polymer.
Conclusion: Hence, different natural polymers (guar gum, xanthan gum and pectin) in various proportions can be used to prepare matrix tablets of
Torsemide having controlled therapeutic effect with improved patient compliance.
Keywords: Torsemide, Guar gum, Xanthan gum, Pectin, Controlled Release, Matrix Tablets.
Downloads
References
Martinho N, Damge C, Reis CP. Recent advances in drug delivery systems. J Biomater Nanobiotechnol 2011;2:510-26.
Helfand WH, Cowen DL. Evolution of pharmaceutical oral dosage forms. Pharm Hist 1983;25(1):3-18.
Kushal M, Monali M, Durgavati M. Oral controlled release drug delivery system: An overview. Int Res J Pharm 2013;4(3):70-6.
Malviya R, Srivastava P, Kulkarni GT. Applications of mucilages in drug delivery- A review. Adv Biol Res 2011;5(1):1-7.
Nokhodchi A, Raja S, Patel P, Asare-Addo K. The role of oral controlled release matrix tablets in drug delivery systems. Bioimpacts 2012;2(4):175-87.
Preobrazhenskii DV, Nekrasova NI, Khoseva EN, Arystanova A, Talyzina IV, Pataraia SA. Torasemide is the effective loop diuretic for long-term therapy of arterial hypertension. Kardiologiia 2011;51(4):67‑73.
Jain S, Yadav SK, Patil UK. Preparation and evaluation of sustained release matrix tablet of furosemide using natural polymers. Res J Pharm Tech 2008;1(4):374-6.
Preobrazhenskii DV, Sidorenko BA, Tarykina EV, Batyraliev TA, Marenich AV. Torasemide – new generation loop diuretic: Clinical pharmacology and therapeutic application. Kardiologiia 2006;46(10):75-86.
Lyseng-Williamson KA. Torasemide prolonged release. Drugs 2009;69(10):1363-72.
Dunn CJ, Fitton A, Brogden RN. Torsemide: An update of its pharmacological properties and therapeutic efficacy. Drugs 1995;49 (1):121-42.
Lower SF, Murray KM. Torsemide: A new loop diuretic. Am J Health Syst Pharm 1995;52:1771-80.
Gennaro A, editor. Remington: The Science and Practice of Pharmacy. 21st ed. Easton: Mack Publishing Company; 2006. p. 917.
Moorthy SU, Kumawat MM, Reddy RT, Someshwar K. Formulation of sustain release solid dispersions of verapamil hydrochloride using ethyl cellulose and eudragit-RSPO. Int J Pharm Pharm Sci 2011;3(1):116-22.
Giri S, Velmurugan S, Chowdary S. Formulation and evaluation of glipizide sustain release matrix tablets. Int J Pharm Pharm Sci 2013;5(1):354-60.
Higuchi T. Mechanism of sustained-action medication theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;52:1145-9.
Korsmeyer RW, Gunny R, Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm 1983;15:25-35.
Lin SY, Wang SL. Advances in simultaneous DSC-FTIR microspectroscopy for rapid solid-state chemical stability studies: Some dipeptide drugs as examples. Adv Drug Deliv Rev 2012;64(5):461-78.
Velmurugan S, Deepika B, Nagaraju K. Formulation and in vitro evaluation of buccal tablets of piroxicam. Int J ChemTech Res 2010;2(3):1958-68.
Nagaraju K, Velmurugan S, Deepika B, Vinushitha S. Formulation and in-vitro evaluation of buccal tablets of metoprolol tartrate. Int J Pharm Pharm Sci 2011;3(2):239-46.
Skoog DA, Holler FJ, Nieman T. Principles of Instrumental Analysis. 5th ed. New York: Saunders College Publishing; 1998. p. 805-8.
O’Neill MJ. The analysis of a temperature-controlled scanning calorimeter. Anal Chem 1964;36(7):1238-45.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.