ACUTE ORAL TOXICITY OF SINAPIS ALBA IN SWISS ALBINO MICE
Abstract
The objective of this study to investigate the acute oral toxicity effects of Sinapis alba seeds in swiss albino female mice based on OECD guideline 423.
The ethanolic extract was administered orally at two different doses of 300 mg/kg and 2000 mg/kg of body weight. The female mice were observed
continuously for 4 hrs for behavioural and autonomic profiles and for any other sign of toxicity or mortality up to a period of 14 days. In between
14 days observation; body weight, feed, and water intake were also observed on 1st, 7th and 14th day. At the end of 14 day's observation, female mice
from each group were sacrificed by cervical dislocation and vital organs were removed, weighed and made histological sections. All results were
shown that there were no any toxic effects, feed and water intake were maximum on 7th day. Body weight, organ weight and histological sections were
also normal.
Keywords: Acute oral toxicity study, Sinapis alba seeds ethanolic extract, Feed and water intake, Body weight, Vital organ weight, Histology.
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