A CLINICAL STUDY OF PAPILLARY CARCINOMA OF THYROID
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i2.43627Keywords:
Thyroid neoplasm, Papillary carcinoma of thyroid, Goiter, FNAC, Total thyroidectomyAbstract
Objectives: The main objectives of the present study are to analyze the incidence of papillary carcinoma of the thyroid, study the clinical presentation and behavior of papillary carcinoma of the thyroid, and analyze various surgical modalities of the treatment of papillary carcinoma of the thyroid.
Methods: It is a prospective study. A proforma for the study of all papillary carcinoma of thyroid patients was used. The presentation, clinical findings, investigations, and management line were documented. The study was conducted during the period December 2016–November 2018. A total of 50 cases of papillary carcinoma of thyroid in GIMSR-Visakhapatnam were selected based on simple random sampling techniques were clinically evaluated.
Results: Among the 66 cases reported with different thyroid types of carcinoma, papillary thyroid cancer constitutes 75%. The results showed that 76% of cases occurred between the age group of 21–50 years. The incidence of female to male ratio was 3.2:1. In 62% of cases, goiter was the most presenting symptom and 92%of patients were euthyroid at the time of presentation.
Conclusion: The incidence of papillary thyroid carcinoma in the present study is 75%, following the results of the previous studies. The most common mode of clinical presentation was thyroid swelling which was lower than those in a comparative study. The proportion of different histopathological types of papillary thyroid cancer was similar to those reported in the literature. The most common complication was transient hypoparathyroidism which resolved with calcium supplementation.
Downloads
References
Woolner LB, Beahrs OH, Black BM, McConahey WM, Keating FR Jr.
Classification and prognosis of thyroid carcinoma. A study of 885 cases
observed in a thirty year period. Am J Surg 1962;102:354.
Simpson WJ. Papillary and follicular thyroid cancer. Prognostic factors
in 1578 patients. Am J Med 1987;83:479.
de Groot LJ. Natural history, treatment and course of papillary thyroid
carcinoma. J Clin Endocrinol Metab 1990;71:414.
Doughlas LF, Skarulis M, Livolsi V. Thyroid Tumours. Cancer-
Principles and Practice of Oncology. 6th ed. Pennsylvania, United
States: Lippincott Williams and Wilkins; 2002. p. 1757.
Ashcraft MW, van Herle AJ. Management of thyroid nodules. I: History
and physical examination, blood tests, X-ray tests, and ultrasonography.
Head Neck Surg 1981;3:216.
Samuel AW Jr. Total thyroidectomy, lymph node dissection for cancer.
In: Robert JB, Josef EF, editors. Mastery of Surgery. 4th ed., Vol. 2.
United States: Lippincott, Williams & Wilkins; 2001. p. 500-11.
Souba WW, Fink MP, Jurkovich GJ, Kaiser LR, Pearce WH, Pemberton
JH, et al., editors. ACS Surgery: Principles and Practice. Hamilton,
ON: BC Decker Inc.; 2007.
Shrikhande SS, Phadke AA. Papillary carcinoma of thyroid gland.
A clinicopathological study of 241 cases. Cancer 1985;55:805-28.
Mitra RB, Pathak S, Guha D, Patra SP, Chowdhury BR. Fine needle
aspiration cytology of thyroid gland and histopathological correlationrevisited.
J Indian Med Assoc 2002;100:382-4.
Kishore N, Srivasthava A, Sharma LK, Chumber S, Kochupillai N,Griwan MS, et al. Thyroid neoplasms-a profile. Indian J Surg 1996;56:143-8.
Tabaqchali MA, hanson JM, Johnson SJ, Wadehra V, Lennard TW, Proud G. Thyroid aspiration cytology in Newcastle: A six years cytology/ histology correlation study. Ann R Coll Surg Engl 2000;82149-55.
Afroze N, Kayani N, Hasan SH. Role of fine needle aspiration cytology in the diagnosis of palpable thyroid lesions. Indian J Pathol Microbiol 2002,45:241-6.
Kamal MM, Arjune DG, Kulkarni HR. Comparative study of fine needle aspiration and fine needle capillary sampling of thyroid lesion. Acta Cytol 2002;46:30-4.
Mazzaferri EL, Young RL. Papillary thyroid carcinoma: A 10 year follow-up report of the impact of therapy in 576 patients. Am J Med 1981;70:511-8.
Dorairajan N, Pandiarajan R, Uvaraja S. A descriptive study of papillary thyroid carcinoma in a teaching hospital in Chennai, India. Asian J Surg 2002;25:300-3.
Guillamondegui OM, Mikhail RA. The treatment of differentiated carcinoma of the thyroid gland. Selective management? Arch Otolaryngol 1983;109:743-5.
Gardiner KR, Russell CF. Thyroidectomy for large multinodular colloid goitre. In J R Coll Surg Edinb 1996;40:367-70.
Delbridge L, Reeve TS, Khadra M, Poole AG. Total thyroidectomy: The technique of capsular dissection. Aust N Z J Surg 1992;62:96-9.
Mundasad B, Mcallister I, Carson J, Pyper PC. Accuracy of FNAC in thyroid swelling diagnosis. Internet J Endocrinol 2006;2:15-9.
Akslen LA, Livolsi VA. Prognostic significance of histologic grading compared with subclassification of papillary thyroid carcinoma. Cancer 2000;88:1902-8.
Pasieka JL, Zedenius J, Auer G, Grimelius L, Höög A, Lundell G, et al. Addition of nuclear DNA content to the AMES risk-group classification for papillary thyroid cancer. Surgery 1992;112:1154-9; discussion 1159-60.
Shrikhande SS, Phadke AA. Papillary carcinoma of the thyroid gland. A clinicopathological study of 241 cases. Cancer 1985;55:805-28.
Published
How to Cite
Issue
Section
Copyright (c) 2021 Yugandhar Gandupalli, SANTOSH KUMAR G, MOUNIKA ANITHA CH, YUGANDHAR G
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.