EFFECT OF LYCOPENE ON CHRONIC MILD STRESS-INDUCED HYPERLIPIDEMIA IN WISTAR ALBINO RATS

DEEPAK SHANKARAPPA; VENKATA NAVEEN KUMAR P; LOURDU JAFRIN A; SOMA SUNDARAM G

doi:10.22159/ajpcr.2022.v15i2.43899

Authors

DEEPAK SHANKARAPPA Department of Pharmacology, Sri Lakshminarayana Institute of Medical Sciences, Pondicherry, India.
VENKATA NAVEEN KUMAR P Department of Pharmacology, Indira Gandhi Medical College and Research Institute Pondicherry, India.
LOURDU JAFRIN A 2Department of Pharmacology, Indira Gandhi Medical College and Research Institute Pondicherry, India.
SOMA SUNDARAM G Department of Pharmacology, Sri Lakshminarayana Institute of Medical Sciences, Pondicherry, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i2.43899

Keywords:

Chronic mild stress, Lycopene, Hyperlipidemia

Abstract

Objective: Chronic mild stress is the most valid model in inducing depression in rodents. In this method, rats were subjected to CMS for 6 weeks of stress.

Methods: In this method, rodents were subjected to a series of mild stressors for CMS for six weeks in an unpredictable manner.

Results: Biochemical and pathological changes were observed. Lycopene treatment at 10 mg/kg and 20 mg/kg could revert these biochemical changes. Histopathological studies showed there is a neuronal loss in CMS and CMS+Vehicle groups. Lycopene treatment reverted this condition.

Conclusion: Lycopene treatment might revert this biochemical change by inhibiting a rate-limiting enzyme, HMG-CoA reductase. Histopathology of the brain revealed that rats subjected to chronic mild stress showed a decreased neuronal loss in the hippocampus. Lycopene treatment showed a neuroprotective effect against CMS-induced neuronal loss.

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