A CROSS-SECTIONAL STUDY OF ANTIHYPERTENSIVE DRUG UTILIZATION PATTERN IN RURAL POPULATION OF SOUTHERN INDIA

KISHAN DHANIYALA; VURIMI BHOPAL CHANDRA; SRIHARSHA RAYAM

doi:10.22159/ajpcr.2022.v15i3.43912

Authors

KISHAN DHANIYALA Final MBBS Part II, Narayana Medical College, Nellore, Andhra Pradesh, India. https://orcid.org/0000-0002-7688-9470
VURIMI BHOPAL CHANDRA Department of Pharmacology, Narayana Medical College, Nellore, Andhra Pradesh, India.
SRIHARSHA RAYAM Department of Pharmacology, Katuri Medical College, Guntur, Andhra Pradesh, India. https://orcid.org/0000-0003-4344-9636

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i3.43912

Keywords:

Antihypertensive drugs, Angiotensin converting enzyme inhibitors, Angiotensin receptor blockers, Calcium channel blocker

Abstract

Objectives: The objective of the study is to study the antihypertensive drug utilization pattern, demographic profile, and associated comorbid conditions of hypertensive patients in the rural population of Southern India.

Methods: This study was a cross-sectional, community-based, door-to-door survey of hypertensive patients. The details of the patients which include age, sex, body mass index (BMI), past medical history, usage of drugs for hypertension (HTN), any other related drugs, and comorbid conditions were collected in this study.

Results: As per the results, the mean age of study participants was 54.68 years, men were 62.31% women were 37.68%, mean BMI was 30.48 kg/m2. In associated comorbidities with HTN, Diabetes was the most common with 19.4%. As per usage of antihypertensive drugs, In Monotherapy, angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs) occupy 16.4% followed by beta-blockers (BB) 13.4%.In 2+ drug therapy, Diuretics were 26.8% followed by BB 22.7% and in drug combinations, the combination of ACE/ARB + Diuretics were 11.5% followed by ACE/ARB + calcium channel blocker at 8.2%.

Conclusion: HTN was more common in Men and the BMI was also on the higher side in hypertensive patients. In associated comorbidities with HTN, Diabetes was the most common disease. Antihypertensive drugs usage pattern shows that in monotherapy, ACE inhibitors/ARBs were the most commonly used drugs. In 2+ therapy, the most common add-on drugs were diuretics. In combination therapy, the most common combination was ACE/ARB + Diuretics.

Downloads

Download data is not yet available.

References

Gakidou E, Afshin A, Abajobir AA, Abate KH, Abbafati C, Abbas KM, et al. Global, regional, and national comparative risk assessment of behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: A systematic analysis for the Global Burden of Disease study. Lancet 2016;390:1345-422.

Cidda M, Mateti UV, Batchu MK, Martha S. Study of prescribing patterns of antihypertensives in South Indian population. Int J Basic Clin Pharmacol 2014;3:303-7.

Basu S, Millett C. Social epidemiology of hypertension in middle-income countries. Determinants of prevalence, diagnosis, treatment, and control in the WHO SAGE study. Hypertension 2013;62:18-26.

Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, et al. Hypertension in India. A systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens 2014;32:1170-7.

Bansal SK, Saxena V, Kandpal SD, Gray WK, Walker RW, Goel D. The prevalence of hypertension and hypertension risk factors in a rural Indian community: A prospective door to door study. J Cardiovasc Dis Res 2012;3:117-23.

Sepehri G, Talebizadeh N, Mirzazadeh A, Mohsenbeigi M. The patterns of antihypertensive drug prescription by cardiologists in Kerman Province of Iran, 2006. Pharmacoepidemiol Drug Saf 2008;17:180-5.

Chiang CW, Chen CY, Chiu HF, Wu HL, Yang CY. Trends in the use of antihypertensive drugs by outpatients with diabetes in Taiwan, 1997- 2003. Pharmacoepidemiol Drug Saf 2007;16:412-21.

Kulkarni SK, Tiwari H, Kumar A. Prescription monitoring of antihypertensive drug utilization at the Punjab university health Centre in India. Singapore Med J 2004;45:117-20.

McInnis NH, Fodor G, Moy Lum-Kwong MM, Leenen FH. Antihypertensive medication use and blood pressure control: A community-based cross-sectional survey (ON-BP). Am J Hypertens 2008;21:1210-5.

By Y, Mr NG, Ag U. Prevalence, awareness, treatment, and control of hypertension in rural areas of Davanagere. Indian J Community Med 2010;35:138-41.

Radhika AR. Drug utilization study of antihypertensive drugs in a tertiary care hospital. Int J Basic Clin Pharmacol 2018;7:2309-13.

Kaur S, Gupta S, Kumar D, Lal M, Gilani Z. Prescribing pattern of antihypertensive drugs in a tertiary care hospital in Jammu: A descriptive study. JK Pract 2012;17:38-41.