MULTICOMPONENT ONE-POT SYNTHESIS OF NOVEL INDOLE ANALOGUES AS POTENT ANTIOXIDANT AGENTS
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i6.43926Keywords:
Indole, Multicomponent reaction, Antioxidant, DNA cleavage activitiesAbstract
Objective: The purpose of this study was to design and synthesize innovative multicomponent one-pot indole analogues that would be effective antioxidants for the body.
Methods: A novel series of indolyl-pyrimidine derivatives were synthesized and characterized by spectrum analysis, and their antioxidant activity and DPPH, total antioxidant capacity, ferric reducing antioxidant power methods, and DNA cleavage activity were examined.
Results: Compound 6a displayed promising free radical scavenging and total antioxidant properties. Compound 6b has demonstrated excellent ferric reducing activity, which is due to the presence of a “CH3” substitution at five position of indole. When compared to a standard DNA marker, compound 6a demonstrated the highest DNA cleavage activity at desired concentrations.
Conclusion: We have synthesized novel pyrimidine analogues containing an indole moiety to investigate drug-like molecules. We have devised that a method that is simple, multicomponent, has a short reaction time, and is ecologically benign.
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