The CLINICOEPIDEMIOLOGICAL FEATURES OF COVID-19 PATIENTS OF SECOND WAVE AT A TERTIARY CARE TEACHING HOSPITAL IN GUJARAT, INDIA

Authors

  • HIREN M CHAWDA Department of Pharmacology, Dr. N. D. Desai Faculty of Medical Science and Research, Nadiad, Gujarat, India
  • RUTVIJ H HEDAMBA Department of Pharmacology, Dr. N. D. Desai Faculty of Medical Science and Research, Nadiad, Gujarat, India https://orcid.org/0000-0002-0190-0292
  • NITIN KOTHARI Department of Pharmacology, Government Medical College, Dungarpur, Rajasthan, India
  • KIRAN M PANCHAL Department of Pharmacology, Dr. N. D. Desai Faculty of Medical Science and Research, Nadiad, Gujarat, India https://orcid.org/0000-0001-9766-3254

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i4.44327

Keywords:

Coronavirus disease-2019, Clinicoepidemiological features, Comorbidities, Intensive care unit, Second wave, Wave-2, COVID-19 deceased

Abstract

Objective:

The studies describing the clinicoepidemiological features of coronavirus disease-2019 (COVID-19) patients of first wave are available but about second wave very few studies have documented. This study was aimed to describe the clinicoepidemiological features and the causes of mortality of COVID-19 patients of second wave admitted in our center.

Methods: This retrospective observational cross sectional study was carried out among 200 randomly selected and confirmed COVID-19 indoor patients admitted between 7th April, 2021 and 3rd July, 2021 in Dr. N. D. Desai Hospital, Nadiad. The demographic profile, clinical features, comorbidities, inflammatory markers and causes of mortality in these patients were analyzed.

Results: A total 200 patients of COVID-19 of second wave were analyzed. Majority of them were males (64.5%) and the patients between 18 and 60 years of age constituted 60%. Hypertension (70.93%) and Diabetes mellitus (46.51%) were common comorbidities followed by ischemic heart diseases and chronic kidney disease. The most common presenting features were fever (75.7%), cough (68.8%), and shortness of breath (60%). The median duration of hospital stay was 7 days [interquartile range (IQR), 4–12]. The patients needed any kind of mode of oxygen therapy were 82.5%. The most common cause of death was cardiac arrest (70.58%) followed by severe acute respiratory distress syndrome ARDS (35.29%). 

Conclusions: In this retrospective study, most patients were young males with the age less than 60 years. The patients had one or more comorbidities, hypertension being the most common. Inflammatory markers were significantly higher in patients who died in our hospital.

Keywords: COVID-19, Clinicoepidemiological features, Comorbidities, ICU, Second wave, Wave-2, COVID-19 deceased, Mortality.

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References

Coccia M. The impact of first and second wave of the COVID-19 pandemic in society: Comparative analysis to support control measures to cope with negative effects of future infectious diseases. Environ Res 2021;197:111099. doi: 10.1016/j.envres.2021.111099, PMID 33819476

Lata S, Khajuria V, Sawhney V. treatment pattern of COVID-19 patients in a tertiary care teaching hospital of northern India. Asian J Pharm Clin Res 2021;14:48-51. doi: 10.22159/ajpcr.2021.v14i11.42345

CDC, WHO, ECDC. +WIKIPEDIA. Available from: http://www. bing.com/search?q=statistics+about+covid+19+pandemicdata. [Last accessed on 2021 Feb 22].

Aggarwal R, Bhatia R, Kulshrestha K, Soni KD, Viswanath R, Singh AK, et al. Clinico epidemiological features and mortality analysis of deceased patients with COVID-19 in a tertiary care center. Indian J Crit Care Med 2021;25:622-8. doi: 10.5005/jp-journals-10071-23848, PMID 34316140

Gupta N, Agrawal S, Ish P, Mishra S, Gaind R, Usha G, et al. Clinical and epidemiologic profile of the initial COVID-19 patients at a tertiary care centre in India. Monaldi Arch Chest Dis 2020;90:193-6. doi: 10.4081/monaldi.2020.1294, PMID 32290644

Pavan KM, Revathi G, Supraja K, Sechana K. Study of demographic analysis, clinical characteristics, diagnosis, management, and complications in COVID-19 patients. Asian J Pharm Clin Res 2021;14:64-8.

Jalali SF, Ghassemzadeh M, Mouodi S, Javanian M, Akbari Kani M, Ghadimi R, et al. Epidemiologic comparison of the first and second waves of coronavirus disease in Babol, North of Iran. Caspian J Intern Med 2020;11 Suppl 1:S544-50.

Jain VK, Iyengar KP, Vaishya R. Differences between First wave and Second wave of COVID-19 in India. Diabetes Metab Syndr 2021;15:1047-8. doi: 10.1016/j.dsx.2021.05.009, PMID 33992554

Budhiraja S, Indrayan A, Aggarwal M, Jha V, Jain D, Tarai B, et al. Differentials in the characteristics of COVID-19 cases in Wave-1 and Wave-2 admitted to a network of hospitals in North India. medRxiv 2021. doi: 10.1101/2021.06.24.21259438.

Iftimie S, López-Azcona AF, Vallverdú I, Hernández-Flix S, de Febrer G, Parra S, et al. First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain. PLoS One 2021;16:e0248029. doi: 10.1371/journal.pone.0248029, PMID 33788866

Kumar G, Mukherjee A, Sharma RK, Menon GR, Sahu D, Wig N, et al. Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study. Indian J Med Res 2021;153:619-28. doi: 10.4103/ ijmr.ijmr_1628_21, PMID 34259194

Tamura RE, Said SM, de Freitas LM, Rubio IGS. Outcome and death risk of diabetes patients with COVID-19 receiving pre-hospital and in-hospital metformin therapies. Diabetol Metab Syndr 2021;13:76. doi: 10.1186/s13098-021-00695-8, PMID 34256824

Tobin MJ, Laghi F, Jubran A. Why COVID-19 silent hypoxemia is baffling to physicians. Am J Respir Crit Care Med 2020;202:356-60. doi: 10.1164/rccm.202006-2157CP, PMID 32539537

Indian SARS-CoV-2 Genomic Consortia (INSACOG) Key Aspects; May 06, 2021. Available from: http://dbtindia.gov.in/sites/default/files/ INSACOG%20Key%20Aspects%20May%206%202021.pdf. [Last accessed on 2021 May 27].

Published

07-04-2022

How to Cite

CHAWDA, H. M., R. H. HEDAMBA, N. . KOTHARI, and K. M. PANCHAL. “The CLINICOEPIDEMIOLOGICAL FEATURES OF COVID-19 PATIENTS OF SECOND WAVE AT A TERTIARY CARE TEACHING HOSPITAL IN GUJARAT, INDIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 4, Apr. 2022, pp. 118-21, doi:10.22159/ajpcr.2022.v15i4.44327.

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Original Article(s)