A REVIEW: SYNTHESIS AND MEDICINAL IMPORTANCE OF 1,4-BENZOTHIAZINE ANALOGUES
Abstract
The ultimate beneficiary of scientific advances is discovering new and better therapeutic agents. 1,4-benzothiazine forms an important class of
heterocyclic system, contains both N and S. Consequently, there have been various efforts for the production of novel 1,4-benzothiazine derivatives
possessing various biological activities such as anti-hypertensive, anti-HIV, anti-inflammatory, antimicrobial, anti-rheumatic, ATP-sensitive potassium
channel opener, cardiovascular, cytotoxic, immunomodulator, neuroprotective, antioxidant, antimalarial and aldose reductase inhibitor etc. As a part
of an ongoing effort toward finding novel pharmacological active agents, it was thought worthwhile to synthesize hybrids of 1,4-benzothiazine.
Keywords: 1,4-Benzothiazine, Ring expansion reaction, Biological activity, 2-aminothiophenol.
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