THE RELATIONS BETWEEN NEUTROPHIL-LYMPHOCYTIC RATIO AND DIFFERENT COMORBIDITIES IN CORONAVIRUS-INFECTED PATIENTS

Authors

  • NIKHIL AGRAWAL Department of General Medicine, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
  • AKASH BHARTI Department of General Medicine, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India.
  • SHAAVI MITTAL Department of General Medicine, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i6.44779

Keywords:

Covid-19, Neutrophil-to-lymphocyte ratio, Diabetes mellitus, Hypertension, Hyperlipidemia

Abstract

Aim: The study’s aim was to determine the neutrophil-to-lymphocyte ratio (NLR) is most helpful predictor factor for COVID-19-related serious illness.

Methods: A total of 51 patients with COVID-19 infection with laboratory-confirmed reports were enrolled in this study: Age, neutrophil-to-lymphocyte (LYMLYM) ratio (NLR), an examination, and comparison. Data analysis, compilation, and report writing were completed based on the acquired data. Using SPSS.ver-23, standard statistical procedures were used to analyze the mean and standard deviation, as well as the Pearson correlation. If p<0.05, it is deemed significant.

Results: The mean hemoglobin level was 12.44±3.55%, the mean platelet count was 1.95±0.65 cumm, the mean white blood cell count was 17400 ±6455.22 cumm, and the mean NLR was 5.72±1.24. When we looked at people who had hypertension, diabetes mellitus, and high cholesterol, we found that the NLR value was significantly higher in people with these diseases (p=0.05).

Conclusion: We found that NLR is an excellent way to predict COVID-19-infected patients who are likely to get a lot of other illnesses and have a lot of problems early on.

Downloads

Download data is not yet available.

References

Drosten C, Günther S, Preiser W, Van der werf S, Brodt HR, Becker S, et al. Identification of a novel coronavirus in patients with the severe acute respiratory syndrome. N Engl J Med 2003;348:1967-76. doi: 10.1056/NEJMoa030747, PMID 12690091

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med 2020;382:929-36. doi: 10.1056/NEJMoa2001191, PMID 32004427

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506. doi: 10.1016/S0140-6736(20)30183-5, PMID 31986264

Liu H, Zhang H, Wan G, Sang Y, Chang Y, Wang X, et al. Neutrophil-lymphocyte ratio: A novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure. J Viral Hepat 2014;21:499-507. doi: 10.1111/jvh.12160, PMID 24750274

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020;323:1061-9. doi: 10.1001/ jama.2020.1585, PMID 32031570

Lagunas-Rangel FA. Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. J Med Virol 2020;92:1733-4. doi: 10.1002/jmv.25819, PMID 32242950

Qu R, Ling Y, Zhang YH, Wei LY, Chen X, Liu XY, et al. Platelet-to-lymphocyte ratio is associated with prognosis in coronavirus disease-19. J Med Virol 2020;92:1533-41. doi: 10.1002/jmv.25767, PMID 32181903

Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta 2020;506:145-8. doi: 10.1016/j. cca.2020.03.022, PMID 32178975

Leung JM, Yang CX, Tam A, Shaipanich T, Hackett TL, Singhera GK, et al. ACE-2 expression in the small airway epithelia of smokers and COPD patients: Implications for COVID-19. Eur Respir J 2020;55:2000688. doi: 10.1183/13993003.00688-2020, PMID 32269089

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020;395:507- 13. doi: 10.1016/S0140-6736(20)30211-7, PMID 32007143

Liu WJ, Zhao M, Liu K, Xu K, Wong G, Tan W, et al. T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV. Antiviral Res 2017;137:82-92. doi: 10.1016/j.antiviral.2016.11.006, PMID 27840203

Shi Y, Wang Y, Shao C, Huang J, Gan J, Huang X, et al. COVID-19 infection: The perspectives on immune responses. Cell Death Differ 2020;27:1451-4. doi: 10.1038/s41418-020-0530-3, PMID 32205856

Guo L, Wei D, Zhang X, Wu Y, Li Q, Zhou M, et al. Clinical features predicting mortality risk in patients with viral pneumonia: The MuLBSTA score. Front Microbiol 2019;10:2752. doi: 10.3389/ fmicb.2019.02752, PMID 31849894

Murillo-Zamora E, Medina-González A, Zamora-Pérez L, Vázquez- Yáñez A, Guzmán-Esquivel J, Trujillo-Hernández B. Performance of the PSI and CURB-65 scoring systems in predicting 30-day mortality in healthcare-associated pneumonia. Med Clin (Barc) 2018;150:99-103. doi: 10.1016/j.medcli.2017.06.044, PMID 28778682

Published

07-06-2022

How to Cite

AGRAWAL, N., A. BHARTI, and S. MITTAL. “THE RELATIONS BETWEEN NEUTROPHIL-LYMPHOCYTIC RATIO AND DIFFERENT COMORBIDITIES IN CORONAVIRUS-INFECTED PATIENTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 6, June 2022, pp. 116-8, doi:10.22159/ajpcr.2022.v15i6.44779.

Issue

Section

Original Article(s)

Most read articles by the same author(s)