PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ANDROGRAPHIS PANICULATA AND VITEX NEGUNDO FOR ANALGESIC ACTIVITY
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i1.44803Keywords:
Analgesia, Analgesic models, Nociception, Hot plate, Tail immersionAbstract
Background: Pain is defined physical or mental depending on it source of origin and pain treated with anti-anxiety, antidepressant, and analgesic medicine. Andrographis paniculata locally called kalmegh of Acanthaceae family and Vitex negundo locally called nirgundi of Lamiaceae, both medicinal plants which yield the therapeutic compound and herbal drug used cure diseases.
Methods: The analgesic activity was performed by hot plat and tail immersion method. The present study extract performs models plants 50 Swiss albino mice four groups of each five animals. This experimental animal administered with extract intraperitoneal at dose level 50, 100, and 300 mg/kg used as reference drugs diclofenac sodium-induced time test using albino mice as experimental animal.
Results: Medicinal plants ethanolic extract contains reducing carbohydrate, flavonoids, tannins, and triterpenoids. The sample comparable antibacterial cytotoxic activity. The different solvent soluble and mild activity herbal drug analgesic highest activity compared to standard drug, diclofenac sodium.
Conclusion: Analgesic models based different parameter for studies bioactive compounds further for isolation and purification compounds.
Downloads
References
Samy RP, Pushparaj PN, Gopalakrishnakone P. A compilation of bioactive compounds from ayurveda. Bioinformation 2008;3:100-10. doi: 10.6026/97320630003100, PMID 19238245
World Health Organization. Cancer Pain Relief and Palliative Care: Report of a WHO Expert Committee [Meeting held in Geneva from 3 to 10 July 1989]. Geneva: World Health Organization; 1990.
Das A, Panda S. Use of topical corticosteroids in dermatology: An evidence-based approach. Indian J Dermatol 2017;62:237-50. doi: 10.4103/ijd.IJD_169_17, PMID 28584365
Kulkarni SK, Akula KK, Deshpande J. Evaluation of antidepressant-like activity of novel water-soluble curcumin formulations and St. John’s Wort paradigms of despair. Pharmacology 2012;89:83-90. doi: 10.1159/000335660, PMID 22343362
Sugiura YA, Terui NA, Hosoya YA. Difference in distribution of central terminals between visceral and somatic unmyelinated (C) primary afferent fibers. J Neurophysiol 1989;62:834-40. doi: 10.1152/ jn.1989.62.4.834, PMID 2809705
Subhose V, Srinivas P, Narayana A. Basic principles of pharmaceutical science in ayurvĕda. Bull Indian Inst Hist Med Hyderabad 2005;35:83-92. PMID 17333665
Tiwari S, Singh A. Toxic and sub-lethal effects of oleandrin on biochemical parameters of fresh water air breathing murrel, Channa punctatus (Bloch.). Indian J Exp Biol 2004;42:413-8. PMID 15088692
Kumar S, Bajwa BS, Kuldeep S, Kalia AN. Anti-inflammatory activity of herbal plants: A review. Int J Adv Pharm Biol Chem 2013;2:272-81.
Patel PK, Sahu J, Chandel SS. A detailed review on nociceptive models for the screening of analgesic activity in experimental animals. Int J Neurol Phys Ther 2016;2:44-50.
Kumar SV, Kumar RS, Sudhakar P, Baskar N. Antioxidant, antinociceptive and anti-inflammatory activities of Rhynchosia minima (L) DC. Res J Pharm Technol 2020;13:1855-60.
Hijazi MA, El-Mallah A, Aboul-Ela M, Ellakany A. Evaluation of analgesic activity of Papaver libanoticum extract in mice: Involvement of opioids receptors. Evid Based Complement Alternat Med 2017;2017:8935085.
Yimer T, Birru EM, Adugna M, Geta M, Emiru YK. Evaluation of analgesic and anti-inflammatory activities of 80% methanol root extract of Echinops kebericho M. (Asteraceae). J Inflam Res 2020;13:647-58. doi: 10.2147/JIR.S267154, PMID 33061529
Lalrinzuali K, Vabeiryureilai M, Jagetia GC. Investigation of the anti-inflammatory and analgesic activities of ethanol extract of stem bark of Sonapatha Oroxylum indicum in vivo. Int J Inflam 2016;2016:8247014. doi: 10.1155/2016/8247014, PMID 26925290
Kumar JP, Shankar NB. Analgesic activity of Mollugo pentaphylla Linn. tail immersion method. Asian J Pharm Clin Res 2009;2:61-3.
Salwe K, Mirunalini R, Mano J, Manimekalai K. Evaluation of analgesic activity of Murraya koenigii and Coriandrum sativum leaves extract in animal model. Asian J Pharm Clin Res 2018;11:328-31.
Ahmad F, Khan RA, Rasheed S. Study of analgesic and anti-inflammatory activity from plant extracts of Lactuca Scariola and Artemisia absinthium. J Islamic World Acad Sci 1992;5:111-4.
Jain RA. To study the Attention Deficit Hyperactivity Disorder (ADHD) and to Evaluate the Cognitive, Hyperactive and Impulsive Behavior Against 6-OHDA Hbr Lesioned Sprague Dawley Neonates using Hyperaxe, Curcumin and Quercetin; 2012 ([doctoral dissertation]. Chennai: CL Baid Metha College of Pharmacy).
Basak A, Cooper S, Roberge AG, Banik UK, Chrétien M, Seidah NG. Inhibition of proprotein convertases-1,-7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J 1999;338:107-13. doi: 10.1042/bj3380107, PMID 9931305
Adedapo AA, Adeoye BO, Sofidiya MO, Oyagbemi AA. Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals. J Basic Clin Physiol Pharmacol 2015;26:327-34. doi: 10.1515/ jbcpp-2014-0051, PMID 25153591
Tiwari V. Phytochemical analysis and medicinal value of Kalmegh (Andrographis paniculata Nees). Indian J Appl Pure Biol 2017;32:283-8.
Statile L, Puig MM, Warner W, Bansinath M, Lovitz M, Turndorf H. Droperidol enhances fentanyl and sufentanil, but not morphine, analgesia. Gen Pharmacol 1988;19:451-4.
Divya S, Suresh J, Paramakrishnan N. Phytopharmacological review on Vitex negundo linn. Ann Rom Soc Cell Biol 2021;25:9496-508.
Smrity KK, Sultana S, Hassan MA, Hossain ML. Medicinal activity of Vitex negundo L.(Family: Lamiaceae) leaves extract: Assessment of phytochemical and pharmacological properties. J Pharmacogn Phytochem. 2019;8:3571-5.
Valdiani A, Kadir MA, Tan SG, Talei D, Abdullah MP, Nikzad S. Nain-e Havandi Andrographis paniculata present yesterday, absent today: A plenary review on underutilized herb of Iran’s pharmaceutical plants. Mol Biol Rep 2012;39:5409-24. doi: 10.1007/s11033-011- 1341-x, PMID 22198549
Mitra SK, Kannan R. A note on unintentional adulterations in ayurvedic herbs. Ethnobotanical Leafl 2007;11:11-5.
Published
How to Cite
Issue
Section
Copyright (c) 2022 Manoj Sahu, Divya Sen , Lokesh Verma , Jitendra Banweer
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
