EVALUATION OF DIFFERENT GRADES OF GUAR GUM, ACACIA GUM, AND POLYVINYL PYRROLIDONE AS CROSS-LINKERS IN PRODUCING SUBMICRON PARTICLES

NEGLA ABDULGHANI ELSAYED YAGOUB; ABUBAKAR OSMAN MOHAMED NUR; FADILAH SFOUQ ALEANIZY; ZUHEIR OSMAN

doi:10.22159/ajpcr.2022.v15i6.44923

Authors

NEGLA ABDULGHANI ELSAYED YAGOUB Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
ABUBAKAR OSMAN MOHAMED NUR Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
FADILAH SFOUQ ALEANIZY Department of Pharmaceutics, Pharmacy College, King Saud University, Riyadh, Saudi Arabia.
ZUHEIR OSMAN Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i6.44923

Keywords:

polymer, Guar gum, acacia gum, polyvinyl pyrrolidine, carbamazepine, Emulsification/solvent evaporation technique, stirring rate.

Abstract

Objective: The main goal of this research is to evaluate using of guar gum (GG), Arabic gum, and poly-vinylpyrrolidone, each of two viscosity grades, as crosslinking agents in producing nanoparticles and submicron particles.

Methods: The method used is the preparation of nanoparticles of carbamazepine using two viscosity grades of polymers (GG, acacia gum, and polyvinyl pyrrolidine) by emulsification/solvent evaporation technique. Based on a statistical design composed of mixed 32-levels factors and 13-levels factor was selected for screening and preliminary optimization purposes. The collected nanoparticles from the first portion of all 24 runs were subjected to the following qualifications, particle diameter, polydispersity index (PDI%), zeta potential, entrapment efficiency (EE%), and drug loading.

Results: The study revealed that based on the obtained findings and the associated statistical analysis, influences of stirring rate, polymer type, polymer grade, and polymer loading in different formulation runs resulted in produced particles with different characteristics such as particle size of different formulation series are in sub-micron (0.13–91.83 μm) with EE% (max 52.28%), reduced EE observed in this study can be attributed to lower polymer load in the dispersed phase (1% and 10%) and zeta potential values were small (range 35.69–41.68), all preparation factors have no significant effect on zeta potential, PDI values (close to zero) showed that all the samples formed monodispersions in water and its due to steric hindrance than a surface charge.

Conclusion: The study recommends that different polymers need special techniques for producing cross-linked particles with sub-micron particles, no universal technique can be applied. Keywords: Polymer, Guar gum, Acacia gum, Polyvinyl pyrrolidine, Carbamazepine, Emulsification/solvent evaporation technique, Stirring rate.

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References

Errico C, Bartoli C, Chiellini F, Chiellini E. Poly(hydroxy alkanoates)-based polymeric nanoparticles for drug delivery Hindawi publishing corporation. BioMed Res Int 2009;2009:571702. doi:10.1155/2009/571702

Honary S, Zahir F. Effect of zeta potential on the properties of nano-drug delivery systems-a review (Part 2). Trop J Pharm Res. 2013;12:265-73.

Akbari Z, Amanlou M, Karimi-Sabet J, Golestani A, Niasar MS. Characterization of carbamazepine-loaded solid lipid nanoparticles prepared by rapid expansion of supercritical solution. Trop J Pharm Res 2014;13:1955-61.

Ostwald W. Studien uber die bildung und umwandlung fester korper. Z Phys Chem 1897;22:289.

Fu X, Ping Q, Gao Y. Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres. J Microencapsul 2005;22:705-14.

Rodge AB, Ghatge PU, Wankhede DB, Kokate RK. Isolation purification and rheological study of guar genotypes RGC- 1031 and RGC-1038. J Arid Legumes 2006;3:41-43.

Davidson RL. Hand Book of Edible Gums. New York, London: Academic Press; 1980. p. 22-43.

Yadav N, Khatak S, Sara UV. Solid lipid nanoparticles a review. Int J Appl Pharm 2013;5:8-18

Robinson G, Ross-Murph SB, Morris ER. Viscosity-molecular weight relationships, intrinsic chain flexibility, and dynamic solution properties of guar galactomannan. Carbohydr Res 1982;107:17-32.

Tiwari S, Verma P. Microencapsulation technique by solvent evaporation method study of the effect of process variables. Int J Pharm Life Sci 2011;2:998-1005.

Noyes AA, Whitney WR. The rate of solution of solid substances in their solutions. J Am Chem Soc 1897;19:930-4.

Hillery AM, Florence AT. The effect of adsorbed poloxamer 188 and 407 surfactants on the intestinal uptake of 60nm polystyrene particles after oral administration in the rat. Int J Pharm 1996;132:123-30.

Yagoub NA, Nur AO. The influence of thermal treatment on physical properties of guar gum. Int J Innov Pharm Sci 2013;2:28-33.

Sweetman SC, editor. Martindale: The Complete Drug Reference. 36th ed. London, Chicago: Pharmaceutical Press; 2009.

Vasir JK, Reddy MK, Labhasetwar VD. Nanosystems in drug targeting: Opportunities and challenges. Curr Nanosci 2005;1:47-64.

Reis CP, Neufeld RJ, Ribeiro AJ, Veiga F. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine 2006;2:8-21.

Berger J, Reist M, Mayer JM, Felt O, Gurney R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 2004;57:35-52.

Puglisi G, Fresta M, Giammona G, Ventura CA. Influence of the preparation conditions in poly (ethyl cyanoacrylate) nanocapsule formation. Int J Pharm 1995;125:283-7.

Chen S, Cheng SX, Zhuo RX. Self-assembly strategy for the preparation of polymer-based nanoparticles for drug and gene delivery. Macromol Biosci 2011;11:576-89.

Kocbek P, Baumgartner S, Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly water-soluble drugs. Int J Pharm 2006;312:179-86.

Csaba N, Garcia-Fuentes M, Alonso MJ. The performance of nanocarriers for transmucosal drug delivery. Expert Opin Drug Deliv 2006;3:463-78.

Izumikawa S, Yoshioka S, Aso Y, Takeda Y. Preparation of poly (L-lactide) microsphere of different crystalline morphology and effect of crystalline morphology on drug release rate. J Control Release 1991;15:133-40.

Taylor M, Ginsburg J, Hickey A, Gheyas F. Composite method to quantify powder flow as a screening method in early tablet or capsule formulation development. AAPS PharmSciTech 2000;1:e18.

Prabaharan M. Prospective of guar gum and its derivatives as controlled drug delivery systems. Int J Biol Macromol 2011;49:117-24.

Kumar BP, Chandiran IS, Bhavya B, Sindhuri M. Microparticulate drug delivery system: A review. Indian J Pharm Sci Res 2011;1:19-37.

Quaglia F, Ostacolo L, Mazzaglia A, Villari V, Zaccaria D, Sciortino MT. The intracellular effects of non-ionic amphiphilic cyclodextrin nanoparticles in the delivery of anticancer drugs. Biomaterials 2009;30:374-82.

Mehta RC, Thanoo BC, Deluca PP. Peptide containing microspheres from low molecular weight and hydrophilic poly(d,l-lactide-co-glycolide). J Control Release 1996;41:249-57.

Xiang Li, Anton N, Arpagaus C, Belleteix F, Vandamme TF. Nanoparticles by spray drying using innovative new technology: The büchi Nano spray dryer B-90. J Control Release 2010;147:304-10.

Grzesiak AL, Lang M, Kim K, Matzger AJ. Comparison of the four anhydrous polymorphs of carbamazepine and the crystal structure of form I. J Pharm Sci 2003;92:2260-71.