UTILITY OF PLATELET INDICES IN THROMBOCYTOPENIA
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i10.45570Keywords:
Thrombocytopenia, Platelet Indices, Platelet Count, Mean Platelet Volume, Platelet Distribution WidthAbstract
Objectives: The objectives of the study were to know the role and utility of platelet indices (MPV and PDW) in differentiating the etiology of thrombocytopenia.
Methods: This was a prospective and retrospective study of 400 cases of thrombocytopenia and 100 controls conducted over a period of 17 months from September 2020 to February 2022 at tertiary care hospital, Ahmedabad, Gujarat, India. All patients meeting inclusion criteria were included in the study. Exclusion criteria were radiation/chemotherapy, antiplatelet drugs induced thrombocytopenia, etc. EDTA blood samples were collected and further processed with a Sysmex KX-21 automated hematology analyzer. Platelet count, mean platelet volume (MPV), and platelet distribution width (PDW) were noted and data were statistically analyzed between groups using t-tests.
Results: Out of 400 cases, 304 belong to Group A (increased destruction of platelets) and the remaining 96 were in Group B (decreased production of platelets). Among Group A, causes were classified into immune thrombocytopenic purpura and others. Various infections resulting in thrombocytopenia were in the majority among other causes in Group A. Group B was comprised megaloblastic anemia as the leading cause responsible for thrombocytopenia. MPV and PDW values were high in hyperdestructive Group A compared to Group B and were found significant between various groups.
Conclusion: MPV and PDW along with platelet count can be used as an adjunct laboratory tool for early screening of the underlying cause of thrombocytopenia, which helps clinicians with targeted therapies in clinical management.
Downloads
References
Greer JP, Arber DA, Glader B, List FA, Means RT, Appelbaum FR, et al. In: Rodgers GM, editor. Thrombocytopenia-pathophysiology and Classification. Wintrobes Clinical Hematology. 13th ed. Lippincott Williams and Wilkins; 2012. p. 2465-66, 2563.
Farweez BA, Ibrahim RR, Elsewefy DA. Platelet indices: Consideration in thrombocytopenia. Egypt J Haematol 2014;39:134-8. doi: 10.4103/1110-1067.148240
Rajashekar RB, Mahadevappa A, Patel S. Evaluation of thrombocytopenia in megaloblastic anemia by platelet indices and megakaryocytes-comparison with hypoproduction and hyperdestruction. NJLM 2017;6:18-22.
Parveen S, Vimal M. Role of platelet indices in differentiating hypoproductive and hyperdestructive thrombocytopenia. APALM 2017;4:A288-91. doi: 10.21276/APALM.1357
Vidyadhar S. Diagnostic implication and utility of platelet indices in differentiating hypoproductive and hyperdestructive thrombocytopenia. IOSR JDMS 2019;18:7-11.
Mala KG, Bhandari BJ, Kittur SK. Paramountcy of platelet parameters in thrombocytopenia-our hospital experience. Indian J Pathol Oncol 2018;5:558-62.
Chaitra VT, Inuganti RV, Burela M, Burela M. Role of platelet indices as a predictive tool in hypoproliferative and hyperdestructive type of thrombocytopenia. JCDR 2020;14:EC14-7. doi: 10.7860/ JCDR/2020/43241.13568
Reddy RS, Phansalkar MD, Ramalakshmi PV. Mean platelet volume (MPV) in thrombocytopenia. J Cont Med Annu Dent 2014;2:45-50.
Katti TV, Mhetre SC, Annigeri C. How far are the platelet indices mirror image of mechanism of thrombocytopenia-mystery still remains? Int J Adv Med 2014;1:200-5. doi: 10.5455/2349-3933.ijam20141108
Al-Sharifi LM. Value of platelet indices in diagnosing etiology of thrombocytopenia. JUBPAS 2018;26:153-62.
Numbenjapon T, Mahapo N, Pornvipavee R, Sriswasdi C, Mongkonsritragoon W, Leelasiri A, et al. A prospective evaluation of normal mean platelet volume in discriminating hyperdestructive thrombocytopenia from hypoproductive thrombocytopenia. Int J Lab Hematol 2008;30:408-14. doi: 10.1111/j.1751-553X.2007.00969.x, PMID 18522712
Gulati I, Kumar H, Sheth J, Dey I. Diagnostic implication of mean platelet volume in thrombocytopenia. Med J DY Patil Univ 2017;10:370-5.
Khaleel KJ, Ahmed AA, Anwar MA. Platelet indices and their relations to platelet count in hypoproductive and hyper-destructive thrombocytopenia. Karbala J Med 2014;7:1952-8.
Norrasethada L, Khumpoo W, Rattarittamrong E, Rattanathammethee T, Chai-Adisaksopha CC, Tantiworawit A. The use of mean platelet volume for distinguishing the causes of thrombocytopenia in adult patients. Hematol Rep 2019;11:7732. doi: 10.4081/hr.2019.7732, PMID 30996849
Published
How to Cite
Issue
Section
Copyright (c) 2022 RUPAL J SHAH, ARCHANA K PRAJAPATI, SNEHA SAMIR BABARIA, DR. KAZOOMI PATEL, NEHA AMIT SHAH, NIDHI PATEL
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.