USING ASPEN PLUS TO SIMULATE PHARMACEUTICAL PROCESSES – AN ASPIRIN CASE STUDY
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i9.45749Keywords:
Process simulation, Pharmaceuticals, Aspen Plus, Aspirin, Economic analysisAbstract
Objective: The objective of this paper is to illustrate uses of Aspen Plus (Aspen) to pharmaceutical processes with a specific focus on the production of aspirin. Chemical process simulators such as Aspen have received little attention for pharmaceutical applications; this is due in part to prevalence of dynamic batch reactors, specialized raw materials and products often including solids and solids handling unit operations.
Methods: Aspen was used to first validate an experimental study and then extended to a commercial scale process.
Results: Aspen adequately reproduced the experimental results obtained from a dynamic batch reactor. Extension to the commercial scale illustrated the power of Aspen to simulate pharmaceutical processes as well as provide costing and economic analysis.
Conclusions: It was found that although the modeling of this relatively simple process is more complicated than it initially seemed, Aspen was capable of handling the difficulties inherent in dealing with solids, batch reactions, and crystal growth. In addition, its optimization and economic analysis features provided enhanced flow sheeting functionality. Its batch reactor model, RBATCH, is capable of modeling batch reactors involving multiple solid-liquid reactions following various reaction rate laws.
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References
Petrides DP, Koulouris A, Lagonikos PT. The role of process simulation in pharmaceutical process development and product commercialization. Pharm Eng 2002;22:1-4.
Connelly D. A History of Aspirin; 2014. Available from: https:// pharmaceutical-journal.com/article/infographics/a-history-of-aspirin [Last accessed on 2022 Jun 27].
Squires S. Aspirin: The World’s most Popular Pill Turns 100. The Washington Post, WP Company; 1997. Available from: https://www. washingtonpost.com/archive/lifestyle/wellness/1997/08/05/aspirin-the-worlds-most-popular-pill-turns-100/caa961d1-c7a4-42c7-b1ac- 550193a9a21f/last [Last accessed on 2022 Jun 27].
Joiner DE, Billeter J, McNally ME, Hoffman RM, Gemperline PJ. Comprehensive kinetic model for the dissolution, reaction and crystallization processes involved in the synthesis of aspirin. J Chemometrics 2014;28:420-8. doi: 10.1002/cem.2605.
Aspen Technology, Inc., 20 Crosby Drive, Bedford, Massachusetts 01730 USA; 2022. Available from: https://www.aspentech.com/en [Last accessed on 2022 Aug 05].
Al-Malah KI. Optimization of drug solubility using aspen plus: Acetylsalicylic acid (aspirin) solubility a second case study. Asian J Pharm Clin Res 2020;13:178-84. doi: 10.22159/ajpcr.2020.v13i4.37143.
National Library of Medicine. Acetylsalicylic Anhydride. Bethesda, Maryland: National Library of Medicine; 2022.
Pakowski Z, Mujumdar AS. Drying of Pharmaceutical Products; 2007. Available from: https://www.researchgate.net/publication/265314817_ Drying_of_Pharmaceutical_Productslast [Last accessed on 2020 Aug 04].
Eberhartinger S. Draft Guidelines on BAT and BEP Medical Waste Incineration; 2004. Available from: http://chm.pops.int/Portals/0/docs/ from_old_website/documents/meetings/bat_bep/2nd_session/egb2_ followup/draftguide/5A2medicalwasteincinerationdraftb.pdf [Last accessed on 2022 Jun 28].
Bennett RC. Crystallization from solution. In: Perry’s Chemical Engineers’ Handbook. 6th ed. New York: McGraw-Hill; 1984. p. 24-40.
Mujumdar AS, editor. Handbook of Industrial Drying. 4th ed. Boca Raton, Florida: CRC Press; 2014.
Rangaiah GP, editor. Multi-objective Optimization Techniques and Applications in Chemical Engineering. Singapore: World Scientific Publishing, Pvt. Ltd.; 2009.
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