STUDY OF FASTING PLASMA GLUCOSE AND LIPID PROFILE IN POSTMENOPAUSAL WOMEN
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i9.45884Keywords:
Dyslipidemia, Post menopause, Glucose, Cardiovascular diseaseAbstract
Objectives: The study was designed to determine fasting plasma glucose (FPG) and lipid profiles in postmenopausal women.
Methods: 200 postmenopausal women were enrolled for the study and were compared to 100 normal healthy women of the same age from the Outdoor Patient Department of LN Medical College and research center of Bhopal city. Those fulfilling inclusion and exclusion criteria were enrolled for the study and the blood samples were analyzed for lipid profile and FPG.
Results: Significant higher concentrations of total cholesterol (p<0.001), triglyceride (p<0.001), low-density lipoprotein (LDL) (p<0.001), very LDLs (p<0.001), and FPG (p<0.001) were demonstrated in postmenopausal women when compared with normal healthy women. A significantly lower concentration of high-density lipoprotein (p<0.001) was demonstrated in postmenopausal women when compared with normal healthy women.
Conclusion: Menopausal transition and the related changes in the hormonal milieu (e.g., decreased systemic estradiol (E2) levels) are linked with adverse changes in several indicators of metabolic health. For instance, during the menopausal transition elevated blood glucose levels and adverse changes in serum lipids have been reported.
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References
World Health Organization. Research on the Menopause in the 1990s. Geneva: Report of a WHO Scientific Group, World Health Organization; 1990.
Greendale GA, Lee NP, Arriola ER. The menopause. Lancet 1999;353:571-80.
Matthews KA. Myths and realities of the menopause. Psychosom Med 1992;54:19.
De Aloysio D, Gambacciani M, Meschia M, Pansini F, Modena AB, Bolis PF, et al. The effect of menopause on blood lipid and lipoprotein levels. The Icarus study group. Atherosclerosis 1999;147:147-53.
Jan LS, Isaac S. Section VII reproductive endocrinology 32 menopause. In: Berek JS, editor. Berek and Novak’s Gynecology. 14th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2007.
De Marchi R, Dell’Agnolo CM, Lopes TC, Gravena AA, Demitto MO, Brischiliari SC, et al. Prevalence of metabolic syndrome in pre-and postmenopausal women. Arch Endocrinol Metab 2017;61:160-6.
Kilim SR, Chandala SR. A comparative study of lipid profile and oestradiol in pre-and post-menopausal women. J Clin Diagn Res 2013;7:1596-8.
Dosi R, Bhatt N, Shah P, Patell R. Cardiovascular disease and menopause. J Clin Diagn Res 2014;8:62-4.
Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk Factors for coronary heart disease. N Engl J Med 1989;321:641-46.
Stevenson JC, Crook D, Godsland LF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis 1993;98:83-90.
Kuller LH, Meilahn EN, Cauley JA, Gutai JP, Mathews KA. Epidemiologic studies of menopause: Changes in risk factors and disease. Exp Gerontol 1994;29:495-509.
Kannel WB. Studies of coronary heart disease risk factors: Perspective from the framingham study. Am Heart J 1987;114:413-9.
Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev 2013;34:309-38.
Sidhu D, Naugler C. Fasting time and lipid levels in a community-based population. Arch Int Med 2012;172:1707-10.
Shah S, Nahar P, Vaidya S, Bade G. Effect of menopause on lipid profile in relation to body mass index. Chron Young Sci 2014;5:20-4.
Saha KR, Rahman MM, Paul AR, Das S, Haque S, Jafrin W, et al. Changes in lipid profile of postmenopausal women. Mymensingh Med J 2013;22:706-11.
Shenoy R, Vernekar P. Fasting lipid profile in pre-and postmenopausal women: A prospective study. Int J Sci Stud 2015;3:116-9.
Bade G, Shah S, Nahar P, Vaidya S. Effect of menopause on lipid profile in relation to body mass index. Chron Young Sci 2014;5:20-4.
Jensen J, Nilas L, Christiansen C. Influence of menopause on serum lipids and lipoproteins. Maturitas 1990;12:321-31.
Derby CA, Crawford SL, Pasternak RC, Sowers M, Sternfeld B, Matthews KA. Lipid changes during the menopause transition in relation to age and weight: The study of women’s health across the nation. Am J Epidemiol 2009;169:1352-61.
Matthews KA, Crawford SL, Chae CU, Everson-Rose SA, Sowers MF, Sternfeld B, et al. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? J Am Coll Cardiol 2009;54:2366-73.
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