THE COVID-19 VULNERABILITY IN ASSOCIATION WITH ABO AND RH BLOOD GROUP SYSTEM: AN ANALYTICAL STUDY WITH REVIEW OF LITERATURE

PRIYADARSHINI DEVENDRAPPA; LATHA VARADHARAJ; JYOTHI ANANTHARAJ; JAYASHREE H K; PARAMITA BHOWMIK

doi:10.22159/ajpcr.2022.v15i12.46031

Authors

PRIYADARSHINI DEVENDRAPPA Department of Pathology, Rajarajeswari Medical College, MGR University, Bengaluru, Karnataka, India. https://orcid.org/0000-0003-0895-6480
LATHA VARADHARAJ Department of Pathology, Rajarajeswari Medical College, MGR University, Bengaluru, Karnataka, India.
JYOTHI ANANTHARAJ Department of Pathology, Rajarajeswari Medical College, MGR University, Bengaluru, Karnataka, India.
JAYASHREE H K Department of Pathology, Rajarajeswari Medical College, MGR University, Bengaluru, Karnataka, India.
PARAMITA BHOWMIK Department of Pathology, Rajarajeswari Medical College, MGR University, Bengaluru, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i12.46031

Keywords:

COVID-19, Blood group, Pandemic, Susceptibility

Abstract

Objective: COVID-19 began on March 11, 2020, when the WHO declared a pandemic, caused by the novel coronavirus. At present, millions of COVID-positive cases are reported with an increase in mortality during the second wave. There are various studies and research chronicles available regarding hematology and biochemical criteria in COVID-19 infection. On the other hand, there is an urge to explore of ABO blood group vulnerability of COVID-19-infected patients in our study population. Our aim of this study is to scrutinize the relevance between the ABO, Rh blood types, and the susceptibility to COVID-19 and to study the capable use of the ABO blood group system for risk stratification of COVID-19.

Methods: ABO and Rh grouping data available of 500 COVID-19 positive were collected from our hospital blood bank. Data about the age and gender of each patient are obtained from the Laboratory Information system. The patients who were confirmed to have SARS-CoV-2 infection by RT-PCR and ABO and Rh typing data available are included in the study.

Results: The ABO blood group in 500 people in tertiary care hospital displayed a percentage distribution of 31.8%, 27.4%, 6.4%, and 34.4% for A, B, AB, and O, respectively. The proportion of non-O blood group (A, B, and AB) among patients with COVID-19 was substantially higher compared to the O blood group.

Conclusion: This study reports an association between COVID-19 susceptibleness and the ABO blood group system. Categorically, non-O blood group systems have a greater risk compared to the O blood group system and have a higher risk of ICU admissions due to COVID-19-related complications.

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References

Ryan L. H, Nicholas A. F, Anish R. Mitra DG. Griesdale D V et.al,2020. The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19. Blood Adv: 4(20): 4981–4989

Latz CA, DeCarlo C, Boitano L, et al. 2020 Blood type and outcomes in patients with COVID-19. Ann Hematol;99(9):2113-2118

Zietz M, Tatonetti N, 2020. Testing the association between blood type and COVID-19 infection, intubation, and death. medRxiv.

Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. 2020 Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. Br. J. Haematol; 190(1):24-27.

Cheng Y, Cheng G, Chui CH, et al.2005. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA;293(12):1450-1451.

Gerard C, Maggipinto G, Minon JM, 2020. COVID-19 and ABO blood group: another viewpoint. Br J Haematol;190(2):93-94

Padhi S, Suvankar S, Dash D, et al, 2020. ABO blood group system is associated with COVID-19 mortality: An epidemiological investigation in the Indian population. Transfus Clin Biol;27(4):253-258.

Dzik S., Eliason K., Morris E. B., Kaufman R. M et.al, 2020. COVID-19 and ABO Blood Groups. Distribution Among Whole Blood Donors at Two Different Set, Transfusion; 60 (8), 1883–1884.

Gullion P, Clement M, Sébille V, et al, 2008, Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology;18(12):1085-93)

Abdel M, Reham M, Abdel FT, Alaa S, Aliaa O, The potential use of ABO blood group system for risk stratification of COVID-19 Medical Hypotheses 145 (2020)

Zhao J, et al. Relationship between the ABO blood group and the COVID-19 susceptibility.1–18; 2020. doi:10.1101/2020.03.11.20031096.

Agrawal A, et al, 2014. ABO and Rh (D) group distribution and gene frequency; the first multicentric study in India. Asian J Transfus Sci; 8:121.

Rashmi Rana, Vivek Ranjan, Naveen Kumar,2021. Association of ABO and Rh Blood Group in Susceptibility, Severity, and Mortality of Coronavirus Disease 2019: A Hospital-Based Study From Delhi, India. Front Cell Infect Microbiol;11: 767771

Esref A.C, Solmaz I, Akkoc H, Donmezdil S, Karahan Z, et al,2020. Association Between the Rh Blood Group and the Covid-19 Susceptibility. Int. J. Hematol. Oncol. 31 (2), 081–086

Liu N, Zhang T, Ma L, Zhang H, Wang H, Wei W, et al, 2020. The Impact of ABO Blood Group on COVID-19 Infection Risk and Mortality: A Systematic Review and Meta-Analysis. Blood Rev. 48.